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Hemofiltration in septic patients is not able to alter the plasma concentration of cytokines therapeutically

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References

  1. Bellomo R, Tip** P, Boyce N (1993) Continuous veno-venous hemoflltration with dialysis removes cytokines from the circulation of septic patients. Crit Care Med 21: 522–526

    Article  CAS  PubMed  Google Scholar 

  2. Bellomo R, Tip** P, Boyce N (1995) Interleukin-6 and interleukin-8 extraction during continuous venovenous hemodiafiltration in septic acute renal failure. Ren Fail 17: 457–466

    Article  CAS  PubMed  Google Scholar 

  3. Hoffmann IN, Hard WH, Deppisch R, Faist E, Jochum M, Inthorn D (1996) Effect of hemofiltration on hemodynamics and systemic concentrations of anaphylatoxins and cytokines in human sepsis. Intensive Care Med 22: 1360–1367

    Article  CAS  PubMed  Google Scholar 

  4. Heering P, Morgera S, Schmitz FJ, Schmitz G, Willers R, Schultheiss HP, Strauer BE, Grabensee B (1997) Cytokine removal and cardiovascular hemodynamics in septic patients with continuous venovenous hemofiltration. Intensive Care Med 23: 288–296

    Article  CAS  PubMed  Google Scholar 

  5. Sander A, Armbruster W Sander B, Daul AE, Lange R, Peters J (1997) Hemofiltration increases IL-6 clearance in early systemic inflammatory response syndrome but does not alter IL6 and TNF alpha plasma concentrations. Intensive Care Med 23: 878–884

    Article  CAS  PubMed  Google Scholar 

  6. Van Bommel EF, Hesse CJ, Jutte NH, Zietse R, Bruining HA, Weimar W (1997) Impact of continuous hemofiltration on cytokines and cytokine inhibitors in oliguric patients suffering from systemic inflammatory response syndrome. Ren Fail 19: 443–454

    Article  CAS  PubMed  Google Scholar 

  7. Lonnemann G, Linnenweber S, Burg M, Koch KM (1998) Transfer of endogenous pyrogens across artificial membranes? Kidney Int Supp166:S43–S46

  8. Hoffmann IN, Werdan K, Hard WH, Jochum M, Faist E, Inthorn D (1999) Hemofiltrate from patients with severe sepsis and depressed left ventricular contractility contains cardiotoxic compounds. Shock 12:174–180

    Article  CAS  PubMed  Google Scholar 

  9. Riche F, Panis Y, Laisne MJ, Briard C, Cholley B, Bernard-Poenaru O, Graulet AM, Gueris J, Valleur P (1996) High tumor necrosis factor serum level is associated with increased survival in patients with abdominal septic shock: a prospective study in 59 patients. Surgery 120: 801–807

    Article  CAS  PubMed  Google Scholar 

  10. Van Dissel IT, van Langevelde P, Westendorp RG, Kwappenberg K, Frolich M (1998) Anti-inflammatory cytokine profile and mortality in febrile patients. Lancet 351: 950–953

    Article  CAS  PubMed  Google Scholar 

  11. Gogos CA, Drosou E, Bassaris HP, Skoutelis A (2000) Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options. J Infect Dis 181: 176–180

    Article  CAS  PubMed  Google Scholar 

  12. Waage A, Aasen AO (1992) Different role of cytokine mediators in septic shock related to meningococcal disease and surgery/polytrauma. Immunol Rev 127:221–230

    Article  CAS  PubMed  Google Scholar 

  13. De Vriese AS, Colardyn FA, Philippe JJ, Vanholder RC, De Sutter JH, Lameire NH (1999) Cytokine removal during continuous hemofiltration in septic patients. J Am Soc Nephro 110:846–853

    Google Scholar 

  14. Hoffmann IN, Hard WH, Deppisch R, Faist E, Jochum M, Inthorn D (1995) Hemofiltration in human sepsis: evidence for elimination of immunomodulatory substances. Kidney Int 48:1563–1570

    Article  CAS  PubMed  Google Scholar 

  15. Tetta C, Mariano F, Buades J, Ronco C, Wratten ML, Camussi G (1997) Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. Am J Kidney Dis 30:S57–S65

    Article  CAS  PubMed  Google Scholar 

  16. Schetz M. Non-renal indications for continuous renal replacement therapy (1999) Kidney Int Supp 172:S88–S94

    Article  Google Scholar 

  17. Waage A, Brandtzaeg P, Halstensen A, Kierulf P, Espevik T (1989) The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J Exp Med 169: 333–388

    CAS  Google Scholar 

  18. Van Deuren M (1998) Acute meningococcal disease. A study of clinical management, cytokine activation and regulation. Thesis, University of Nijmegen

  19. Tetta C, Bellomo R, Brendolan A, Piccinni P, Digito A, Dan M, Irone M, Lonnemann G, Moscato D, Buades J, La Greca G, Ronco C (1999) Use of adsorptive mechanisms in continuous renal replacement therapies in the critically ill. Kidney Int Supp 172:S15–S19

    Article  Google Scholar 

  20. Schetz M, Ferdinande P, Van den Berghe G, Verwaest C, Lauwers P (1995) Removal of pro-inflammatory cytokines with renal replacement therapy: sense or nonsense? Intensive Care Med 21:169–176

    Article  CAS  PubMed  Google Scholar 

  21. Silvester W (1997) Mediator removal with CRRT complement and cytokines. Am J Kidney Dis 30:S38–S43

    Article  CAS  PubMed  Google Scholar 

  22. Sieberth HG, Kierdorf HP (1999) Is cytokine removal by continuous hemofiltration feasible? Kidney Int Suppl 72:S79–S83

    Article  CAS  PubMed  Google Scholar 

  23. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, Manogue KR, Faist E, Abraham E, Andersson J, Andersson U, Molina PE, Abumrad NN, Sama A, Tracey KJ (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285:248–251

    Article  CAS  PubMed  Google Scholar 

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van Deuren, M., van der Meer, J. Hemofiltration in septic patients is not able to alter the plasma concentration of cytokines therapeutically. Intensive Care Med 26, 1176–1178 (2000). https://doi.org/10.1007/s001340000583

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