Zusammenfassung
Die Gutenberg Gesundheitsstudie ist eine populationsbasierte, prospektive, monozentrische Kohortenstudie, die seit 2007 an der Universitätsmedizin Mainz durchgeführt wird. Im Rahmen der Studie werden Herz-Kreislauf-Erkrankungen, Krebserkrankungen, Augenerkrankungen, metabolische Erkrankungen sowie Erkrankungen des Immunsystems und der Psyche untersucht. Ziel der Studie ist es, die Risikovorhersage für den Einzelnen für diese Erkrankungen zu verbessern. Hierzu werden Lebensstil, psychosoziale Faktoren, Umwelt, laborchemische Parameter sowie das Ausmaß der subklinischen Erkrankung berücksichtigt. Eine umfangreiche Biomaterialbank ermöglicht molekularbiologische Untersuchungen, unter anderem auch in einem systembiologischen Ansatz. Im Rahmen der Basisuntersuchung wurden 15.000 Individuen im Alter von 35 bis 74 Jahren zu einem fünfstündigen Untersuchungsprogramm in das Studienzentrum eingeladen. Nach 2,5 Jahren wird ein computerassistiertes Telefoninterview (CATI) mit einem standardisierten Interview sowie einer Erhebung von Endpunkten durchgeführt. Nach fünf Jahren erfolgt eine erneute ausführliche Follow-up-Untersuchung im Studienzentrum ähnlich der Eingangsuntersuchung bei Studieneinschluss. Es ist geplant, weitere Untersuchungen zur Nachverfolgung der Kohorte durchzuführen.
Abstract
The Gutenberg Health Study is a population-based, prospective, single-center cohort study that started in 2007 at the University Medical Center Mainz. The project focuses on cardiovascular diseases, cancer, eye diseases, metabolic diseases, diseases of the immune system and mental diseases. The study aims at improving the individual risk prediction for diseases. Therefore, lifestyle, psychosocial factors, environment, laboratory parameters as well as the extent of the subclinical disease are investigated. A comprehensive biobank enables biomolecular examinations including a systems biological approach. During the baseline visit 15,000 individuals aged 35–74 years were invited to a 5 h examination program in the study center. This will be followed by a computer-assisted telephone interview with a standardized interview and assessment of endpoints after 2.5 years. After 5 years a detailed follow-up examination comparable to the visit at study inclusion will be performed in the study center. Further follow-up visits of the cohort are envisaged.
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Danksagung
Wir bedanken uns bei den Studienteilnehmerinnen und Studienteilnehmern der Gutenberg Gesundheitsstudie für die Teilnahme und die Einwilligung in die Bereitstellung von Daten und Biomaterial. Weiterhin danken wir den Mitarbeiterinnen und Mitarbeitern der Gutenberg Gesundheitsstudie für ihre engagierte und begeisterte Arbeit.
Die Gutenberg Gesundheitsstudie (Gutenberg Health Study) wird finanziell unterstützt durch das Forschungsprogramm „Wissen schafft Zukunft“ sowie den „Schwerpunkt Vaskuläre Prävention“ der Universitätsmedizin der Johannes Gutenberg-Universität Mainz, das Land Rheinland-Pfalz („Stiftung Rheinland Pfalz für Innovationen“, AZ 961-386261/733) sowie die Boehringer Ingelheim GmbH und die Philips GmbH.
Acknowledgement
This work/the Gutenberg Health Study is funded through the research programs „Wissen schafft Zukunft“ and „Schwerpunkt Vaskuläre Prävention“ of the University Medical Center, Johannes Gutenberg University Mainz, the government of Rheinland-Pfalz („Stiftung Rheinland Pfalz für Innovationen“, AZ 961-386261/733), and Boehringer Ingelheim GmbH and Philips GmbH including an unrestricted grant.
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P.S. Wild, T. Zeller, M. Beutel, M. Blettner, K.A. Dugi, K.J. Lackner, N. Pfeiffer, T. Münzel, S. Blankenberg für den Leitungsausschuss der Gutenberg Gesundheitsstudie.
T. Münzel und S. Blankenberg haben eine geteilte Seniorautorenschaft.
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Wild, P., Zeller, T., Beutel, M. et al. Die Gutenberg Gesundheitsstudie. Bundesgesundheitsbl. 55, 824–830 (2012). https://doi.org/10.1007/s00103-012-1502-7
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DOI: https://doi.org/10.1007/s00103-012-1502-7