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The novel role of miRNAs for tamoxifen resistance in human breast cancer

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Abstract

The selective estrogen receptor modulator tamoxifen is the most commonly used treatment for patients with ER-positive breast cancer. However, tumor cells often develop resistance to tamoxifen therapy, which is a major obstacle limiting the success of breast cancer treatment. miRNAs, as oncogenic or tumor suppressor genes, regulate the expression and function of their related target genes to affect the biological behaviors of cancer cells, including cancer initiation, progression, metastasis, and therapeutic resistance. In detail, many miRNAs associated with breast cancer tamoxifen resistance have been identified, which offer new targets for breast cancer therapy. Here, we review the miRNAs involved in regulation of tamoxifen resistance in human breast cancer and the mechanism of how the modulation of miRNAs may regulate the sensitivity of breast cancer cells to tamoxifen. We also discuss the future prospects of studies about miRNAs in regulation of tamoxifen resistance and miRNA-based therapeutics for tamoxifen resistance breast cancer patients.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (No. 81470357) and a Foundation for Clinical Medicine Science and Technology Special Project of the Jiangsu Province, China (No. BL2014071) (to X.G.).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Author notes

    Authors and Affiliations

    1. Department of Medical Oncology, **ling Hospital, Medical School of Nan**g University, Nan**g, 210002, China

      Wenwen Zhang, **g Xu, Yaqin Shi, Qian Sun, Qun Zhang & **aoxiang Guan

    Authors
    1. Wenwen Zhang
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    2. **g Xu
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    3. Yaqin Shi
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    4. Qian Sun
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    5. Qun Zhang
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    6. **aoxiang Guan
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    Corresponding author

    Correspondence to **aoxiang Guan.

    Additional information

    W. Zhang, J. Xu and Y. Shi contributed equally to this manuscript.

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    Zhang, W., Xu, J., Shi, Y. et al. The novel role of miRNAs for tamoxifen resistance in human breast cancer. Cell. Mol. Life Sci. 72, 2575–2584 (2015). https://doi.org/10.1007/s00018-015-1887-1

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    • DOI: https://doi.org/10.1007/s00018-015-1887-1

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