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Low renal uptake of 99mTc-DMSA in patients with proximal tubular dysfunction

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Abstract

In nine patients with different types of proximal tubulopathy and a nearly normal glomerular filtration rate a low uptake of 99mTc-DMSA in the kidneys was found. The underlying mechanism seems to be an increased urinary excretion of 99mTc-DMSA. This radiopharmaceutical might be used as a marker of proximal tubular dysfunction.

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References

  • Arnold RW, Subramanian G, McAfee JG, Blair RJ, Thomas FD (1975) Comparison of 99mTc-complexes for renal scanning. J Nucl Med 16:357–367

    Google Scholar 

  • Beekhuis H, van Luÿk WHJ, Piers DA (1979) Differential renal function using 99mTc-DMSA, in vivo correlation. J Nucl Med 20:898–899

    Google Scholar 

  • Cogan MG (1982) Disorders of proximal nephron function. Am J Med 72:275–288

    Google Scholar 

  • Daly MJ, Milufinovic J, Rudd TG, Phillips LA, Fialkow PJ (1979) The normal 99mTc-DMSA renal image. Radiology 128:201–204

    Google Scholar 

  • Elwood CH, Sigman EM, Treger C (1967) The measurement of glomerular filtration rate with 125I-sodium iothalamate (Conray). Br J Radiol 40:581–583

    Google Scholar 

  • Enlander D, Weber PM, dos Remedios LV (1974) Renal cortical imaging in 35 patients: Superior quality with 99mTc-DMSA. J Nucl Med 15:743–749

    Google Scholar 

  • Gulliford P, Carty H (1981) Functional aspects of the relative renal distribution of 99mTc-DMSA from a comparison with 123I-hippurate in children. Nucl Med Commun 2:364–370

    Google Scholar 

  • Handmaker H, Young BW, Lowenstein JH (1975) Clinical experience with 99mTc-DMSA, a new renal imaging agent. J Nucl Med 16:28–32

    Google Scholar 

  • Ikeda I, Inone O, Kurata K (1977) Preparation of various Tc-99m-dimercaptosuccinate complexes and their evaluation as radiotracers. J Nucl Med 18:1222–1229

    Google Scholar 

  • Lin TH, Khentigan A, Winchell HS (1974) A 99mTc-chelate substitute for organoradiomercurial renal agents. J Nucl Med 15:34–35

    Google Scholar 

  • Moretti JL, Rapin JR, Le Poncin M, Lageron A, Saccavini JC, Bardy A (1982) Dimercapto-succinic acid complexes: their structure, biological behaviour and renal localization. In: Joekes AM, Constable AR, Brown NJG, Tauxe WN (ed.), Radionuclides in nephrology. Academic Press, London, p 25–31

    Google Scholar 

  • Rao Chervu L, Blaufox MD (1982) Renal radiopharmaceuticals — an update. Semin Nucl Med 12:224–245

    Google Scholar 

  • Taylor A, Lallone RL, Hagan PL (1980) Optimal handling of dimercaptosuccinic acid for quantitative renal scanning. J Nucl Med 21:1190–1193

    Google Scholar 

  • Vanlic-Razumenic N, Petrovic J (1981) Biochemical studies of the renal radiopharmaceutical compound dimercapto succinate. I. Subcellular localisation of 99mTc-DMSA complex in the rat in vivo. Eur J Nucl Med 6:169–172

    Google Scholar 

  • Yee CA, Lee HB, Blaufox MD (1981) 99mTc-DMSA renal uptake: influence of biochemical and physiologic factors. J Nucl Med 22:1054–1058

    Google Scholar 

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van Luÿk, W.H.J., Ensing, G.J. & Piers, D.A. Low renal uptake of 99mTc-DMSA in patients with proximal tubular dysfunction. Eur J Nucl Med 8, 404–405 (1983). https://doi.org/10.1007/BF00253217

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  • DOI: https://doi.org/10.1007/BF00253217

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