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Functional brain map** of actual car-driving using [18F]FDG-PET

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Abstract

Aims

This study aims at identifying the brain activation during actual car-driving on the road, and at comparing the results to those of previous studies on simulated car-driving.

Methods

Thirty normal volunteers, aged 20 to 56 years, were divided into three subgroups, active driving, passive driving and control groups, for examination by positron emission tomography (PET) and [18F]2-deoxy-2-fluoro-D-glucose (FDG). The active driving subjects (n = 10) drove for 30 minutes on quiet normal roads with a few traffic signals. The passive driving subjects (n = 10) participated as passengers on the front seat. The control subjects (n = 10) remained seated in a lit room with their eyes open. Voxel-basedt-statistics were applied using SPM2 to search brain activation among the subgroups mentioned above.

Results

Significant brain activation was detected during active driving in the primary and secondary visual cortices, primary sensorimotor areas, premotor area, parietal association area, cingulate gyrus, the parahippocampal gyrus as well as in thalamus and cerebellum. The passive driving manifested a similar-looking activation pattern, lacking activations in the premotor area, cingulate and parahippocampal gyri and thalamus. Direct comparison of the active and passive driving conditions revealed activation in the cerebellum.

Conclusion

The result of actual driving looked similar to that of simulated driving, suggesting that visual perception and visuomotor coordination were the main brain functions while driving. In terms of attention and autonomic arousal, however, it seems there was a significant difference between simulated and actual driving possibly due to risk of accidents. Autonomic and emotional aspects of driving should be studied using an actual driving study-design.

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Authors and Affiliations

  1. Divisions of Cyclotron Nuclear Medicine, Cyclotron Radioisotope Center, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, 980-8578, Sendai, Japan

    Myeonggi Jeong, Manabu Tashiro, Laxsmi N. Singh, Keiichiro Yamaguchi, Masayasu Miyake, Shouichi Watanuki & Masatoshi Itoh

  2. Divisions of Radiopharmaceutical Chemistry, Cyclotron Radioisotope Center, Tohoku University, Japan

    Myeonggi Jeong & Ren Iwata

  3. Center for Comprehensive and Community Medicine, Faculty of Medicine, Saga University, Japan

    Etsuo Horikawa

  4. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Japan

    Hiroshi Fukuda

  5. Division of Human Informatics, Graduate School Program, Tohoku Gakuin University, Japan

    Yasuo Takahashi

Authors
  1. Myeonggi Jeong
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  2. Manabu Tashiro
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  3. Laxsmi N. Singh
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  4. Keiichiro Yamaguchi
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  5. Etsuo Horikawa
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  6. Masayasu Miyake
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  7. Shouichi Watanuki
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  8. Ren Iwata
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  9. Hiroshi Fukuda
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  10. Yasuo Takahashi
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  11. Masatoshi Itoh
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Corresponding author

Correspondence to Manabu Tashiro.

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Jeong, M., Tashiro, M., Singh, L.N. et al. Functional brain map** of actual car-driving using [18F]FDG-PET. Ann Nucl Med 20, 623–628 (2006). https://doi.org/10.1007/BF02984660

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  • DOI: https://doi.org/10.1007/BF02984660

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