Abstract
Two novel lactones, CephalosporolidesH (1) andI (2), were isolated from the lyophilized culture broth of the marine-derived fungus,Penicillium sp. The structures were elucidated on the basis of extensive 1D- and 2D-NMR, as well as HRESI-MS spectroscopic analyses. The relative stereochemistries of the compounds were assessed by comparison of the NOESY analysis and spectral data with those in the literature.
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Ackland, M. J., Hanson, J. R., Hitchcock, P. B., and Ratcliffe, A. H. Structures of the cephalosporolides B-F, a group of C [10] lactones from Cephalosporium aphidicola,J. Chem.Soc, Perkin Trans., 1, 843–847(1985).
Blunt, J. W., Copp, B. R., Munro, M. H. G., Northcote, P. T., and Princep, M. R., Marine natural Products,Nat. Prod. Rep., 22, 15–61(2005).
Grabley, S. and Thiericke, R. Drug Discovery from Nature, Springer Verlag press, Berlin, 124–137 (1999).
Juan, L O., Maria, I., Salvador, M., Eulalia, O., Juan, M. C.., and Enrique, O. J., Bassianolone: an antimicrobial precursor of cephalosporolides E and F from the entomoparasitic fungusBeauveria bassiana, Org. Biomol. Chem., 3, 1172–1173 (2005).
Li, X., Zheng, Y, Sattler, I., and Griseusin, C., A novel quinone derivative from a marine-derived fungusPenicillium sp.Arch. Pharm. Res., 29, 942–945 (2006).
Scibert S. F., Krick A., Eguereva E., Kehraus S., andKonig G. M., Ascospiroketals A and B, unprecedented cycloethers from the marine-derived fungusAscochyta salicorniae.Organic Letters, 9, 239–242 (2007).
Vatcharin, R., Songyos, P., Chaveng, P., Masahiko, I., and Sumalee, S., 10-Membered macrolides from the insect pathogenic fungusCordyceps militaris BCC 2816,J. Nat. Prod., 67, 1953–1955(2004).
Xu, M., Gessner, G, Groth, I., Lange, C., Christner, A., Bruhn, T., Deng Z., Li, X., Heinemann, S.H., Grabley, S., Bringmann, G, Sattler, I., and Lin, W., Shearinines D-K, new indole triterpenoids from an endophyticPenicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium- activated potassium channels.Tetrahetron, 63, 435–444 (2007).
Zou, W. X. and Tan R. X., Recent Advances on Endophyte Research.J. Inter. Plant. Bio., 43, 881–892 (2001).
Zou, W. X. and Tan, R. X., Advances in Plant Science. Vol. 2, Bei**g, China Higher Education Press, 183–190 (1999).
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Li, X., Yao, Y., Zheng, Y. et al. Cephalosporolides H and I, two novel lactones from a marine-derived fungus, penicillium sp.. Arch Pharm Res 30, 812–815 (2007). https://doi.org/10.1007/BF02978829
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DOI: https://doi.org/10.1007/BF02978829