Abstract
Three diterpenes (1, 8, and9), three triterpenes (3, 4, and7), one saponin (11), four sterols (2, 5, 6, and12), and one cerebroside (10) were isolated from the EtOH extract of the aerial parts ofAralia cordata by repeated silica gel column chromatography. Their chemical structures were identified by comparing their physicochemical and spectral data with those published in literatures. All isolated compounds were evaluated for their cytotoxicity against L 1210, K562, and LLC tumor cell lines using MTT assay. Of which, 3β, 5α-dihydroxy-6β-methoxyergosta-7,22-diene (6) showed a potent cytotoxicity against all cell lines with IC50 values of 11.7, 11.9, and 15.1 μM, respectively, while compounds1, 5, and11 showed a moderate or weak cytotoxicity. These isolates were also examined for their inhibitory activity against COX-1 and COX-2. Although most compounds, except for2, 10, and12, showed a strong inhibitory activity against COX-1, they exhibited a moderate or weak inhibitory activity against COX-2.
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Lee, I.S., **, W.Y., Zhang, X. et al. Cytotoxic and COX-2 inhibitory constituents from the aerial parts ofAralia cordata . Arch Pharm Res 29, 548–555 (2006). https://doi.org/10.1007/BF02969263
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DOI: https://doi.org/10.1007/BF02969263