SpringerLink
Log in

Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester

  • Published:
Lipids

Abstract

Eicosapentaenoic acid (EPA) ethyl ester (1.8 g/d) was administered to 16 diabetic patients (5 insulin-dependent and 11 noninsulin-dependent diabetics) for 6 mon. EPA in total plasma fatty acids increased from 4.0±2.4 mol% (mean±SD) to 7.5±3.1 mol% (p<0.001). Albumin excretion, measured with spot urine, was significantly reduced from 65 to 36 mg/g creatinine (geometric means, p<0.001). Fasting blood sugar levels, glycohemoglobin, body weight and blood pressure did not change significantly during the study. There were also no significant changes in serum levels of creatinine, urea nitrogen, total cholesterol and triglycerides. Although no overt hemorrhage was observed in the patients, hematocrit was reduced from 42.6±2.8% to 41.0±3.9% (p<0.02). Ten other similar diabetic patients (4 insulin-dependent and 6 non-insulin-dependent diabetics) were followed as a reference group, not concomitantly, for 6 mon with neither EPA ethyl ester nor placebo. The parameters mentioned above were not changed significantly in this group during 6 mon. EPA administration might retard the appearance of overt diabetic nephropathy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (United Kingdom)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

DM:

diabetes mellitus

EPA:

eicosapentaenoic acid

HbA1c :

glycosylated hemoglobin A1c

IDDM:

insulin-dependent diabetes mellitus

NIDDM:

noninsulin-dependent diabetes mellitus

References

  1. Christiansen, J.S., Andersen, A.R., Andersen, J.K., and Deckert, T. (1985)Diabetic Nephropathy 4, 104–106.

    Google Scholar 

  2. Feldt-Rasmussen, B., Mathiesen, E., and Deckert, T. (1986)Lancet 2, 1300–1304.

    Article  PubMed  CAS  Google Scholar 

  3. Dahl-Jørgensen, K., Hanssen, K.F., Kierulf, P., Bjøro, T., Sandvik, L., and Aagenaese, Ø. (1988)Acta Endocrinol. (Copenh) 117, 19–25.

    Google Scholar 

  4. Feldt-Rasmussen, B., Mathiesen, E.R., Hegedüs, L., and Deckert, T. (1986)N. Engl. J. Med. 314, 665–670.

    Article  PubMed  CAS  Google Scholar 

  5. Christensen, C.K., and Mogensen, C.E. (1985)Diabetic Nephropathy 4, 34–40.

    Google Scholar 

  6. Parving, H-H., Andersen, A.R., Smidt, U.M., Hommel, E., Mathiesen, E.R., and Svendsen, P.A.A. (1987)Br. Med. J. 294, 1443–1447.

    CAS  Google Scholar 

  7. Hommel, E., Parving, H-H., Mathiesen, E., Edsberg, B., Damkjaer Nielsen, D., and Giese, J. (1986)Br. Med. J. 293, 467–470.

    Article  CAS  Google Scholar 

  8. Bending, J.J., Dodds, R., Keen, H., and Viberti, G.C. (1986)Diabetologia 29, 516A.

    Google Scholar 

  9. Mogensen, C.E., and Osterby, R. (1987)Front. Diab. 8, 67–81.

    CAS  Google Scholar 

  10. Hamazaki, T., Hirai, A., Terano, T., Sajiki, J., Kondo, S., Fujita, T., Tamura, Y., and Kumagai, A. (1982)Prostaglandins 23, 557–567.

    Article  PubMed  CAS  Google Scholar 

  11. Kobayashi, S., Hamazaki, T., Hirai, A., Terano, T., Tamura, Y., Kanakubo, Y., Yoshida, S., Fujita, T., and Kumagai, A. (1985)Clin. Hemorheol. 5, 493–505.

    Google Scholar 

  12. Hamazaki, T., Nakazawa, R., Tateno, S., Shishido, H., Isoda, K., Hattori, Y., Yoshida, T., Fujita, T., Yano, S., and Kumagai, A. (1984)Kidney Int. 26, 81–84.

    PubMed  CAS  Google Scholar 

  13. Prickett, J.D., Robinson, D.R., and Steinberg, A.D. (1981)J. Clin. Invest. 68, 556–559.

    Article  PubMed  CAS  Google Scholar 

  14. Barcelli, U.O., Miyata, J., Ito, Y., Gallon, L., Laskorzewski, P., Weiss, M., Hitzemann, R., and Pollak, V.E. (1986)Prostaglandins 32, 211–219.

    Article  PubMed  CAS  Google Scholar 

  15. Schaap, G.H., Bilo, H.J.G., Popp-Snijders, C., Oe, P.L., Mulder, C., and Donker, A.J.M. (1987)Life Sci. 41, 2759–2765.

    Article  PubMed  CAS  Google Scholar 

  16. Alexander, N.J., Smythe, N.L., and Jokinen, M.P. (1987)Am. J. Pathol. 127, 106–121.

    PubMed  CAS  Google Scholar 

  17. Kelley, V.E., Ferretti, A., Izui, S., and Storm, T.B. (1985)J. Immunol. 134, 1914–1919.

    PubMed  CAS  Google Scholar 

  18. Robinson, D.R., Prickett, J.D., Polisson, R., Steinberg, A.D., and Levine, L. (1985)Prostaglandins 30, 51–57.

    Article  PubMed  CAS  Google Scholar 

  19. Ito, Y., Barcelli, U.O., Yamashita, W., Weiss, M., Thompson, B., Kashyap, M., Deddens, J., and Pollak, V.E. (1987)Life Sci. 40, 2317–2323.

    Article  PubMed  CAS  Google Scholar 

  20. Elzinga, L., Kelley, V.E., Houghton, D.C., and Bennett, W.M. (1987)Transplantation 43, 271–274.

    Article  PubMed  CAS  Google Scholar 

  21. Papanikolaou, N. (1987)Prostaglandins Leukotrienes Med. 27, 129–149.

    Article  CAS  Google Scholar 

  22. Hamazaki, T., Tateno, S., and Shishido, H. (1984)Lancet 1, 1017–1018.

    Article  PubMed  CAS  Google Scholar 

  23. Fujikawa, M., Yamazaki, K., Sawazaki, S., Taki, H., Kaneda, M., Urakaze, M., Hamazaki, T., Yano, S., and Fujita, T. (1989)Lipids 24, 765–768.

    PubMed  CAS  Google Scholar 

  24. Siess, W., Roth, P., Scherer, B., Kurzmann, I., Böhlig, B., and Weber, P.C. (1980)Lancet 1, 441–444.

    Article  PubMed  CAS  Google Scholar 

  25. Lorenz, R., Spengler, U., Fischer, S., Duhm, J., and Weber, P.C. (1980)Circulation 67, 504–511.

    Google Scholar 

  26. Kamada, T., Yamashita, T., Baba, Y., Kai, M., Setoyama, S., Chuman, Y., and Tsuji, S. (1986)Diabetes 35, 604–611.

    PubMed  CAS  Google Scholar 

  27. Terano, T., Hirai, A., Hamazaki, T., Kobayashi, S., Fujita, T., Tamura, Y., and Kumagai, A. (1983)Atherosclerosis 46, 321–331.

    Article  PubMed  CAS  Google Scholar 

  28. Urakaze, M., Hamazaki, T., Kashiwabara, H., Omori, K., Fischer, S., Yano, S., and Kumagai, A. (1989)Nephron 53, 102–109.

    Article  PubMed  CAS  Google Scholar 

  29. Mortensen, J.Z., Schmidt, E.B., Nielsen, A.H., and Dyerberg, J. (1983)Thromb. Haemostas 50, 543–546.

    CAS  Google Scholar 

  30. Haines, A.P., Sanders, T.A.B., Imeson, J.D., Mahler, R.F., Martin, J., Mistry, M., Vickers, M., and Wallace, P.G. (1986)Thrombosis Res. 43, 643–655.

    Article  CAS  Google Scholar 

  31. Glauber, H., Wallace, P., Griver, K., and Brechtel, G. (1988)Ann. Intern. Med. 108, 663–668.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Kurobe City Hospital, 938, Kurobe City, Toyama, Japan

    Eisuke Takazakura & Kenzo Osawa

  2. First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-01, Toyama-shi, Toyama, Japan

    Tomohito Hamazaki, Masaharu Urakaze & Saburo Yano

Authors
  1. Tomohito Hamazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eisuke Takazakura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kenzo Osawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masaharu Urakaze
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Saburo Yano
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Hamazaki, T., Takazakura, E., Osawa, K. et al. Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester. Lipids 25, 541–545 (1990). https://doi.org/10.1007/BF02537161

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02537161

Keywords

Search

Navigation