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Effect of platelet-activating factor antagonist BN 52063 on the nephrotoxicity of cisplatin

  • PAF and the Renal System
  • Published:
Lipids

Abstract

Cisplatin (DDP) is an effective anticancer agent that has been successfully applied against various solid tumors. However, DDP commonly causes nephrotoxicity. We observed that DDP led to significant alterations in renal microcirculation when administered to Munich-Wistar rats, with a concomitant decrease in single nephron glomerular filtration rate due to reduction in glomerular plasma flow and transcapillary hydraulic pressure difference. BN 52063, a platelet-activating factor antagonist, caused a striking change in acute renal failure induced by DDP leading toward normalization of all parameters of renal function. The results suggest that BN 52063 could be used as a novel drug to control DDP nephrotoxicity.

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Abbreviations

ARF:

acute renal failure

BW:

body weight

CA :

afferent arteriolar protein concentration

CE :

efferent arteriolar protein concentration

CsA:

cyclosporine

DDP:

cis-diamminedichloroplatinum

ΔP:

transcapillary hydraulic pressure difference

FF:

filtration fraction

GFR:

glomerular filtration rate

Hct:

hematocrit

Kf :

glomerular ultrafiltration coefficient

KW:

kidney weight

MAP:

mean arterial pressure

PAF:

platelet-activating factor

PAH:

p-aminohippuric acid

PGC :

glomerular capillary hydraulic pressure

PT :

tubular hydraulic pressure

II A :

afferent colloid osmotic pressure

II E :

efferent colloid osmotic pressure

QA :

glomerular plasma flow rate

RA :

afferent arteriolar resistance

RE :

efferent arteriolar resistance

RT :

total arteriolar resistance

RPF:

renal plasma flow

SNGFR:

single nephron glomerular filtration rate

SNFF:

single nephron filtration fraction

TRVR:

total renal vascular resistance

V:

urinary volume

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Authors and Affiliations

  1. Nephrology Division, Escola Paulista de Medicine, Rua Botucatu 740, 04023, São Paulo, SP, Brazil

    Oscar F. Pavão dos Santos, Mirian A. Boim, Elivo J. G. Barros & Nestor Schor

  2. Institut Henri Beaufour, Les Ulis, France

    Eduardo Pirotzky & Pierre Braquet

Authors
  1. Oscar F. Pavão dos Santos
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  2. Mirian A. Boim
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  3. Elivo J. G. Barros
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  4. Eduardo Pirotzky
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  5. Pierre Braquet
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  6. Nestor Schor
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Pavão dos Santos, O.F., Boim, M.A., Barros, E.J.G. et al. Effect of platelet-activating factor antagonist BN 52063 on the nephrotoxicity of cisplatin. Lipids 26, 1324–1328 (1991). https://doi.org/10.1007/BF02536558

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  • DOI: https://doi.org/10.1007/BF02536558

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