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Obstructing colonic cancer: Failure and survival patterns over a ten-year follow-up after one-stage curative surgery

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Diseases of the Colon & Rectum

Abstract

BACKGROUND: Large-bowel cancers that present as obstructing lesions have a poor prognosis. However, little is known of the reasons for the dismal survival and of failure patterns after potentially curative treatment. METHOD: An observational study and multivariate analysis were conducted to identify determinants of survival and to compare recurrence patterns between obstructing and nonobstructing tumors after primary resection and anastomosis as curative treatment. RESULTS: Over a period of ten years (1980–1989), 528 patients with colonic cancer were treated at one institution. The cancer was obstructing in 179 cases and nonobstructing in 349. One-stage primary resection and anastomosis as curative treatment were performed in 107 obstructed and 256 nonobstructed patients. Three hundred thirty-six potentially cured survivors (94 in the former group and 242 in the latter) were followed for a median of 55 months. During follow-up, local recurrence occurred in 37 patients (12 obstructed (12.8 percent) and 25 nonobstructed (10.4 percent),P=0.44) and metastatic disease in 68 (25 obstructed (27.6 percent) and 43 nonobstructed (17.8 percent),P=0.029). Multivariate analysis of survival showed that age over 70 years, Dukes stage, histologic grade, and recurrence were the only prognostic factors. No statistically significant determinant turned out for local recurrence, whereas at multivariate analysis for metastatic and overall relapse, Dukes stage, positive nodes, and obstruction remained independent prognostic factors. CONCLUSIONS: After one-stage emergency curative treatment, patients presenting with obstructing tumors of the colon have a smaller survival probability than that of patients with nonobstructing lesions. Local recurrence pattern is similar between groups. Conversely, obstruction, along with pathologic stage and positive nodes, carries a significantly higher risk of metastatic tumor recurrence and death.

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Authors and Affiliations

  1. From the Instituto di Chirurgia d'Urgenza, Università di Milano, Ospedale Maggiore Policlinico, Italy

    Paolo G. Setti Carraro M.D., Marco Segala M.D. & Giorgio Tiberio M.D.

  2. Laboratorio di Epidemiologia, Ospedale Maggiore Policlinico, Instituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy

    Bruno M. Cesana M.D.

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  1. Paolo G. Setti Carraro M.D.
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  2. Marco Segala M.D.
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  3. Bruno M. Cesana M.D.
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  4. Giorgio Tiberio M.D.
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Setti Carraro, P.G., Segala, M., Cesana, B.M. et al. Obstructing colonic cancer: Failure and survival patterns over a ten-year follow-up after one-stage curative surgery. Dis Colon Rectum 44, 243–250 (2001). https://doi.org/10.1007/BF02234300

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