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Stereospezifität der Wirkung von Emetin

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Summary

(-)-Emetine, as prepared by total synthesis, has the same antiamebic activity and toxicity as the natural alkaloid. On the contrary its antipode and rac. isoemetine are not active and practically non-toxic. A relationship between configuration and antiamebic activity has thus been demonstrated for various representatives of the emetine series.

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References

  1. A. Brossi, M. Baumann undO. Schnider, Helv. chim. Acta42, 1516 (1959).

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  2. Emetin-hydrochlorid, Ph. H. V. (Sandoz AG., Basel).

  3. T. A. Henry,The Plant Alkaloids 4th ed. (J. & A. Churchill, London 1949), p. 402.

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Authors and Affiliations

  1. Forschungsabteilung der F. Hoffmann-La Roche & Co., A.G., Basel

    A. Brossi, Z. Brener, J. Pellegrino, H. Stohler & J. R. Frey

  2. Instituto Nacional de Endemias Rurais, Belo Horizonte, Brasilien

    Z. Brener & J. Pellegrino

Authors
  1. A. Brossi
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  2. Z. Brener
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  3. J. Pellegrino
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  4. H. Stohler
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  5. J. R. Frey
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Brossi, A., Brener, Z., Pellegrino, J. et al. Stereospezifität der Wirkung von Emetin. Experientia 16, 64–65 (1960). https://doi.org/10.1007/BF02170262

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  • DOI: https://doi.org/10.1007/BF02170262

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