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Mechanochemical preparation of drug carrier solid dispersions

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Abstract

The method of mechanical activation was used to obtain solid-state dispersions of some drugs in polyvinylpyrrolidone, polyethylene glycol and talc as carriers. Solid dispersions obtained by mechanical activation were found to have higher apparent solubilities and dissolution rates than mechanically activated drugs or their physical or eutectic mixtures with carriers used. It was shown by IR-spectroscopy and fluorescence measurements that mechanical treatment gave rise to an interaction between components which was apparently responsible for the solubilization effects observed.

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Authors and Affiliations

  1. Institute of Solid State Chemistry, Kutateladze 18, 630128, Novosibirsk, Russia

    T. P. Shakhtshneider, M. A. Vasilchenko, A. A. Politov & V. V. Boldyrev

Authors
  1. T. P. Shakhtshneider
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  2. M. A. Vasilchenko
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  3. A. A. Politov
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  4. V. V. Boldyrev
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Shakhtshneider, T.P., Vasilchenko, M.A., Politov, A.A. et al. Mechanochemical preparation of drug carrier solid dispersions. Journal of Thermal Analysis 48, 491–501 (1997). https://doi.org/10.1007/BF01979496

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