SpringerLink
Log in

Influence of parenteral fat administration on the pulmonary vascular system in man

  • Original Articles
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

In 16 patients with multiple injuries the effect of parenteral administration of a fat emulsion on the pulmonary vascular system has been studied. Using the Hewlett Packard 5600 A Intensive Care System, which allows vital parameters to be sampled at a rate of two values per min, pulmonary artery pressure (PAP) was monitored before, during, and after the administration of Lipofundin S 20% (0.24 g/kg/h). In addition right ventricular stroke work index (RVSWI), alveolar-arterial oxygen difference (A-aDO2) and pulmonary shunt (Qs/Qt) were calculated. The results indicate that there are no changes of the PAP, the RVSWI, and the A-aDO2 during the period of observation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bayley JA, Clements AJ (1967) Pulmonary and circulatory effect of fibrinopeptides. Circ Res 21:469

    PubMed  Google Scholar 

  2. Birke G, Carlson LA, Liljedahl S (1965) Lipid metabolism and trauma III. Plasma lipids and lipoproteins in burns. Acta Med Scand 178:337

    PubMed  Google Scholar 

  3. Brücke P (1973) Die Pathophysiologie der Lungen bei experimenteller Fettembolie. In: Wiemers K (ed) Lungenveränderungen bei Langzeitbeatmung. Thieme, Stuttgart, pp 127

    Google Scholar 

  4. Carlson LA (1966) Lipid mobilisation in traumafriend and foe. In: Morgan AP (ed) Proceedings of Conference on Energy Metabolism and Body Fuel Utilization. Cambridge, Massachusetts. Harvard University Printing Office, p 123

    Google Scholar 

  5. Dölp F (1977) Diskussionsbemerkung. In: Wretlind A (ed) Anaesthesiologie und Wiederbelebung, vol 103, Fettemulsionen in der parenteralen Ernährung. Springer, Berlin Heidelberg New York p 218

    Google Scholar 

  6. Eckart J (1977) Diskussionsbemerkung. In: Wretlind A (ed): Fettemulsionen in der parenteralen Ernährung. Springer, Berlin Heidelberg New York, p 211

    Google Scholar 

  7. Epple E, Hohnsbeen KP, Bleicher W, Kempter BE, Nagel M (1978) Improved medical research from computer assisted intensive care system. IEEE Catalog No. 78, CH 1191-2C, Computers in Cardiology, Stanford 329

  8. Greene H, Hazlett D, Demarre R, Dremesi J (1972) Effect of intralipid on pulmonary function in normal humans and on electron microscopy of rabbit lung and liver. Presented at the International Congress of Nutrition, Mexico City

  9. Gurd AR (1970) Fat embolism: An aid to diagnosis. J Bone Jt Surg 52 B:732

    Google Scholar 

  10. Hiesinger E, Weller R, Kempter BE, Frey R, Epple E (1979) Computergestützte Krankenblatterstellung in der Intensivüberwachung. Biomed. Technik 24:246

    Google Scholar 

  11. Holliday RL, Viidik T, Jennings B (1978) Lipid metabolism in stress. In: Johnston, DA (ed) Advances in parenteral nutrition. MTP Press, Lancaster, p 179

    Google Scholar 

  12. Huth K, Schönborn W, Börner J (1967) Zur Pathogenese der Univerträglichkeitserscheinungen bei parenteraler Fettzufuhr. Med Ernähr 8:146

    Google Scholar 

  13. Huth K, Schmahl FW (1977) Experimentelle Untersuchungen zur Wirkung parenteraler Fettgabe. In: Wretlind A (ed) Anästhesiologie und Wiederbelebung, Fettemulsionen in der parenteralen Ernährung. Vol 103, Springer, Berlin Heidelberg New York p 133

    Google Scholar 

  14. Jonsson CE, Lindquist O, Malmberg P (1974) Efflux of prostaglandins in right lymphatic duct lymph following induced intravascular coagulation and inhibited fibrinolysis in the dog. Scand J Clin Lab Invest 33:361

    PubMed  Google Scholar 

  15. Lindquist O, Bagge O, Saldeen T. Induction of endogenous fibrinolysis inhibition in the dog. Effects of intravascular coagulation and release of free fatty acids

  16. Meng HC (1978) Changes in lipid metabolism under stress. In: Johnston DA (ed) Advances in parenteral nutrition. MTP Press, Lancaster, p 195

    Google Scholar 

  17. Modig J, Busch C, Olerud S, Saldeen T (1974) Pulmonary microembolism during intramedullary orthopaedic trauma. Acta Anaesth Scan 18:133

    Google Scholar 

  18. Modig J, Busch C, Olerud S, Saldeen T, Waernbaum G (1975) Arterial hypotension and hypoxaemia during total hip replacement: The importance of thromboplastic products, fat embolism and acrylic monomers. Acta Anaesth Scan 19:28

    Google Scholar 

  19. Modig J, Medstrand U, Fischer J, Lundström J (1976) Early recognition and treatment of posttraumatic pulmonary microembolism. Crit Care Med 4:180

    PubMed  Google Scholar 

  20. Modig J (1977) Posttraumatic pulmonary microembolism. Pathophysiology and treatment. Ann Clin Res 9:164

    PubMed  Google Scholar 

  21. Pohlandt F, Töllner U, Klör HU, Mohr W (1977) Biochemische und histologische Untersuchungen zur Verträglichkeit einer Fettemulsion in der parenteralen Ernährung von Neugeborenen. In: Wretlind A (ed) Fettemulsionen in der parenteralen Ernährung. Anästhesiologie und Wiederbelebung. Springer, Berlin Heidelberg New York, p 171

    Google Scholar 

  22. Radegran K (1971) Circulatory and respiratory effects of induced platelet aggregation. An experimental study in dogs. Acta Chir Lab Invest 14:138

    Google Scholar 

  23. Ruiz B, Tucker W, Kirby R (1975) A program for calculation of intrapulmonary shunts, blood-gas and acid-base-values with a programmable calculator. Anesthesiology 42:88

    PubMed  Google Scholar 

  24. Saldeen T (1966) Experimental investigation to fat embolism and intravascular coagulation. Acta Pathol Microbiol Scand 67:271

    Google Scholar 

  25. Saldeen T (1969) Quantitative determination of intravascular coagulation in the lungs of experimental animals. J Haematol 6:205

    Google Scholar 

  26. Saldeen T (1970) The importance of intravascular coagulation and inhibition of fibrinolytic system in experimental fat embolism. J Trauma 10:287

    PubMed  Google Scholar 

  27. Saldeen T, Busch L, Rammer L (1970) Trauma and intravascular coagulation. Acta Pathol Microbiol Scand [A] 78:491

    Google Scholar 

  28. Staudacher C, Di Carlo V, Cristallo M (1979) Morphological alterations in shock lung. An electron microscopic study. In: Mayrhofer, Krammel O (eds) Akutes progressives Lungenversagen, INA, vol 16. Thieme, Stuttgart, p 8

    Google Scholar 

  29. Vaage J, Piper PJ (1975) The release of prostaglandin-— like substances during platelet aggregation and pulmonary microembolism. Acta Physiol Scand 94:8

    PubMed  Google Scholar 

  30. Vogel A (1977) Diskussionsbemerkung. In: Wretland, A (ed) Fettemulsionen in der parenteralen Ernährung. Springer, Berlin Heidelberg New York, p 209

    Google Scholar 

  31. Wilmore DW, Major MC, Moylan JA, Helmkamp GM, Captain MSC, Pruitt BA, Colonel MC (1973) Clinical evaluation of a 10% intravenous fat emulsion for parenteral nutrition in thermally injured patients. Ann Surg 178:503

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zentralinstitut für Anästhesiologie der Eberhard-Karls-Universität, Tübingen, FRG

    K. van Deyk, V. Hempel, F. Münch, M. Kopp, H. Graf & E. Epple

  2. Institut für Anästhesiologie Stadtklinik, Balger Straße 50, D-7570, Baden-Baden, FRG

    K. van Deyk

Authors
  1. K. van Deyk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Hempel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Münch
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Kopp
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Graf
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E. Epple
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

van Deyk, K., Hempel, V., Münch, F. et al. Influence of parenteral fat administration on the pulmonary vascular system in man. Intensive Care Med 9, 73–77 (1983). https://doi.org/10.1007/BF01699260

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01699260

Key words

Search

Navigation