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A primate model for acute and late cerebral vasospasm: Angiographic findings

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Summary

A subarachnoid haemorrhage (SAH) in the squirrel monkey was produced by injection of blood via a permanently implanted catheter connected to the cisterna magna and a cannula stereotactically inserted into the interpeduncular cistern. Repeated angiographic examinations of the vertebro-basilar and right internal carotid arteries revealed a biphasic vasospasm with a maximal acute spasm at ten minutes and maximal late spasm at six days after blood injection. The present study has shown that a reproducible biphasic vasospasm can be produced in the squirrel monkey and evaluated by repeated angiographic examinations. The model is suitable in the study of basic mechanisms underlying vasospasm in a primate and, due to the size of the animal, autoradiographic evaluation of the cerebral blood flow and metabolism can be performed at an acceptable cost.

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Authors and Affiliations

  1. Neurosurgical Research Department, University Hospital, Lund, Sweden

    T. J. Delgado-Zygmunt & M. A. -R. Arbab

  2. Neurosurgical Department, Karolinska Sjukhuset, Stockholm, Sweden

    Y. Shiokawa & N. -A. Svendgaard

Authors
  1. T. J. Delgado-Zygmunt
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  2. M. A. -R. Arbab
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  3. Y. Shiokawa
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  4. N. -A. Svendgaard
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Delgado-Zygmunt, T.J., Arbab, M.A.R., Shiokawa, Y. et al. A primate model for acute and late cerebral vasospasm: Angiographic findings. Acta neurochir 118, 130–136 (1992). https://doi.org/10.1007/BF01401298

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  • DOI: https://doi.org/10.1007/BF01401298

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