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41. Immunreaktivität, ein präoperativ faßbarer Parameter?

Immunoreactivity, a preoperative assessible risk parameter?

  • B. Wissenschaftliches Programm
  • I. Hauptthemen mit Diskussion D. Chirurgische Risikoforschung
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Summary

The perioperative risk of 44 patients with a malignoma of the esophagus, stomach or colon was estimated by a check list of risk parameters. There was no satisfactory correlation between preoperative risk estimation and postoperative complications. A remarkable increase of this correlation was achieved by additional measurement of the phagocytosis activity of the PNM tested by the Zymosan induced chemiluminescence. The predicting value of this retrospective evaluated parameter of operative risk estimation and immunoreactivity was further investigated by a prospective study on 132 patients with an intestinal carcinoma.

Zusammenfassung

Bei 44 Patienten mit einem Malignom des Oesophagus, Magens oder Colons wurde das operative Risiko präoperativ an Hand einer Risikocheckliste objektiviert. Eine befriedigende Klassifizierung in 3 Risikogruppen in Korrelation zur postoperativen Komplikationsrate war nur durch zusätzliche Berücksichtigung der Phagocytosefähigkeit der PNM gemessen über die Zymosan-induzierte Chemiluminescenz im Vollblut der Patienten möglich. Die Risikowertigkeit dieses retrospektiv erhobenen Risikoparameters der Immunreaktivität wurde prospektiv an 132 Malignompatienten untersucht. Auch in der prospektiven Studie ließ sich eine deutlich bessere Trennschärfe der präoperativen Risikobeurteilung erzielen.

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Authors and Affiliations

  1. Chirurgische Universitätsklinik Hamburg-Eppendorf, Martinistraße 52, D-2000, Hamburg 20

    B. Kremer, C. Früh, N. P. Homann, K. Reuter & D. Bornholdt

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Kremer, B., Früh, C., Homann, N.P. et al. 41. Immunreaktivität, ein präoperativ faßbarer Parameter?. Langenbecks Arch Chiv 361, 269–275 (1983). https://doi.org/10.1007/BF01275866

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