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Structures of the oligosaccharides isolated from milk of the platypus

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Abstract

Eight major oligosaccharides were isolated from platypus milk. By sequential exoglycosidase digestion and methylation study, their structures were elucidated as shown in Fig. 9 of this paper. The characteristics feature of the platypus milk oligosaccharides is that lacto-N-neotetraose and lacto-N-neohexaose are the major cores in contrast to human milk oligosaccharides in which lacto-N-tetraose and lacto-N-hexaose are found as the major core.

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Authors and Affiliations

  1. Department of Biochemistry, the Institute of Medical Science, University of Tokyo, Minato-ku, 108, Tokyo, Japan

    Junko Amano & Akira Kobata

  2. Department of Biochemistry, University of Sydney, 2006, Sydney, N.S.W., Australia

    Michael Messer

Authors
  1. Junko Amano
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  2. Michael Messer
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  3. Akira Kobata
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Abbreviations: All sugars mentioned in this paper have thed-configuration except for fucose which has thel-configuation. The postscript OT is used in this paper to indicate NaB3H4-reduced oligosaccharides. In the same way, the postscript OH is used to indicate NaBH4-reduced oligosaccharides.

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Amano, J., Messer, M. & Kobata, A. Structures of the oligosaccharides isolated from milk of the platypus. Glycoconjugate J 2, 121–135 (1985). https://doi.org/10.1007/BF01050469

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  • DOI: https://doi.org/10.1007/BF01050469

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