Summary
Alzheimer's neurofibrillary tangles were studied by electron microscopy. The study includes four cases of Alzheimer's disease, two cases of atypical senile dementia, and one case of progressive supranuclear palsy. In Alzheimer's disease the tangles were composed of either straight filaments or paired helical filaments. In progressive supranuclear palsy the tangles were composed of 15 nm straight filaments or helical filaments. A few straight filaments were mixed with paired helical filaments. In atypical senile dementia, both straight and paired helical filaments comprised the tangles and one type of filaments appeared to intermingle with the other in the same neurons.
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References
Bugian L, Marcardi GL, Brusa A, Ederli E (1979) The fine structure of subcortical tangles in progressive supranuclear palsy. Acta Neuropathol (Berl) 45:147–152
Burger PC, Vogel FS (1973) The development of pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. Am J Pathol 73:457–477
Crapper DR, Krisschnan SS, Quittat S (1976) Aluminium, neurofibrillary degeneration and Alzheimer's disease. Brain 99:67–80
De Boni U, Crapper DR (1978) Paired helical filaments of the Alzheimer's type in cultured neurones. Nature 271:566–568
Grundke-Iqbal I, Johnson A, Terry RD, Wisniewski HM, Iqbal K (1978) Alzheimer neurofibrillary tangles: Antiserum and immunohistochemical staining. Ann Neurol 6:532–537
Grundke-Iqbal I, Johnson A, Wisniewski HM, Terry RD, Iqbal K (1979) Evidence that Alzheimer neurofibrillary tangles originate from neurotubules. Lancet 2:578–580
Haper CG, Buck D, Gonatas NK, Guilbert B, Avraneas S (1979) Skin fibroblast microtubular network in Alzheimer disease. Ann Neurol 6:548–552
Higgins RJ, Vandevelde M, Hoff EJ, Jagar JE, Cork LC, Silberman MS (1977) Neurofibrillary accumulation in the Zebra (Equus Burchelli) Acta Neuropathol (Berl) 37:1–5
Hirano A, Demblitzer HM, Kurland LT, Zimmerman HM (1968) The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and “rod-like” structure as seen in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex. J Neuropathol Exp Neurol 27:167–182
Ishii Y, Itoh T (1979) An autopsy case of progressive supranuclear palsy. Chin Neurol (Tokyo) 19:187
Iqbal K, Wisnicwski HM, Grundke-Iqbal I, Korthals JK, Terry RD (1975) Chemical pathology of neurofibers. Neurofibrillary tangles of Alzheimer's presenile dementia. J Histochem Cytochem 23:563–569
Iqbal K, Grundke-Iqbal I, Wisniewski HM, Terry RD (1978) Chemical relationship of the paired helical filaments of Alzheimer's dementia to normal human neurofilaments and neurotubules. Brain Res 142:321–332
Iqbal K, Wisniewski HM, Shelanski ML, Brostoff B, Liwnicz BH, Terry RD (1974) Protein changes in senile dementia. Brain Res 77:337–343
Kuroda S, Otsuki S, Tateishi J, Hirano A (1979) Neurofibrillary degeneration in a case of quadriplegia and myocolonic movements. Acta Neuropathol (Berl) 45:105–109
Lampert P (1971) Fine structural changes of neurites in Alzheimer's disease. Acta Neuropathol (Berl) (Suppl) 5:49–53
Mandybur TI, Nagpaul AS, Pappas Z, Niklowitz WJ (1977) Alzheimer neurofibrillary change in subacute sclerosing panencephalitis. Ann Neurol 1:103–107
Niklowitz WJ, Mandybur TI (1975) Neurofibrillary changes following child lead encephalopathy. Case report. J Neuropathol Exp Neurol 34:444–455
Oyanagi S (1979) Aging of central nervous system and its fine structure. Neurofibrillary change and senile plaques. Seishin Igaku 21:834–846 (in Japanese)
Oyanagi S (1974) On ultrastructure of the aging structure of the brain. Brain Nerve (Tokyo) 26:637–653
Shibayama H, Kitoh J (1978) Electron microscopic structure of the Alzheimer's neurofibrillary changes in a case of atypical senile dementia. Acta Neuropathol (Berl) 41:229–234
Schochet SS (1968) Neuronal changes induced by intrathecal vincristine sulfate. J Neuropathol Exp Neurol 27:645–658
Tellez-Nagel I, Wisniewski HM (1973) Ultrastructure of neurofibrillary tangles in Steele-Richardson-Olszewski syndrome. Arch Neurol 29:324–327
Tomonaga M (1977) Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathol (Berl) 37:177–181
Volk B (1980) Paired helical filaments in rat spinal ganglia following chronic alcohol administration: An electron microscopic investigation. Neuropathol Appl Neurobiol 6:143–153
Wisniewski HM, Ghetti B, Terry RD (1973) Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol 32:566–584
Wisniewski HM, Narang J, Terry RD (1976) Neurofibrillary tangles of paired helical filaments. J Neurol Sci 27:173–181
Wisniewski HM, Narang HK, Corsellis JA, Terry RD (1976) Ultrastructural studies of the neuropil and neurofibrillary tangles in Alzheimer's disease and post-traumatic demantia. J Neuropathol Exp Neurol 35:367
Yagishita S, Itho Y, Nakano T, Amano N, Saitoh A (1979) Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy. Acta Neuropathol (Berl) 48:27–30
Yagishita S, Itoh Y, Amano N, Nakano T (1980) Atypical senile dementia with widespread Lewy type inclusions in the cerebral cortex. Acta Neuropathol (Berl) 49:187–191
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Yagishita, S., Itoh, Y., Nan, W. et al. Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles. Acta Neuropathol 54, 239–246 (1981). https://doi.org/10.1007/BF00687747
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DOI: https://doi.org/10.1007/BF00687747