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Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus

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Serum deoxyribonuclease I (DNase I) activity in systemic lupus erythematosus (SLE) patients was shown to be lower than that of healthy laboratory personnel, rheumatoid arthritis, and scleroderma patients (P<0.001). The decrease in DNase I activity in SLE sera was not due to the effect of various autoantibodies or to heat labile DNase I inhibitor. A relationship between serum DNase I activity and active SLE was demonstrated. Patients with active lupus nephritis had the lowest levels of enzymatic activity.

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Authors and Affiliations

  1. Division of Rheumatic Diseases, University of Colorado Health Sciences Center, 4200 East 9th Avenue, 80262, Denver, Colorado, USA

    S. Chitrabamrung, R. L. Rubin & E. M. Tan

Authors
  1. S. Chitrabamrung
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  2. R. L. Rubin
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  3. E. M. Tan
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Chitrabamrung, S., Rubin, R.L. & Tan, E.M. Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus. Rheumatol Int 1, 55–60 (1981). https://doi.org/10.1007/BF00541153

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