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Natural killer cell activity in atopic dermatitis

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Summary

Natural killer (NK) cell activity against K562 cells was studied in 12 male adults with atopic dermatitis (AD). In a 4-h chromium relase microcytotoxicity assay normal NK cell function and its augmentation by interferon (IFN-alpha) were observed in AD patients. Slightly higher NK cell activity was observed in patients with allergic respiratory symptoms. The role of NK cells in the pathogenesis of atopic dermatitis is discussed.

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Authors and Affiliations

  1. Dept. of Medical Microbiology, University of Turku, SF-20520, Turku 52, Finland

    M. Viander, J. Uksila & O. Lassila

  2. Dept. of Dermatology, University of Turku, SF-20520, Turku 52, Finland

    Ch. T. Jansén

Authors
  1. M. Viander
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  2. J. Uksila
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  3. O. Lassila
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  4. Ch. T. Jansén
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Additional information

Supported by Oy Star Ab and a grant from the Foundation for Allergy Research (Allergiatutkimussäätiö), Finland

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Viander, M., Uksila, J., Lassila, O. et al. Natural killer cell activity in atopic dermatitis. Arch Dermatol Res 274, 283–288 (1982). https://doi.org/10.1007/BF00403731

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  • DOI: https://doi.org/10.1007/BF00403731

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