Summary
Five patients (1 female and 4 males) with cerebral infarction of 4 h to 27 months duration were studied 9 times with magnetic resonance (MR) using Gd-DTPA. Spin-echo (SE) MR images (MRI) were obtained before and after the administration of Gd-DTPA, and correlative CT scans were performed on the same day. In 2 cases, 4 h and 27 months after the ictus, there was no enhancement with Gd-DTPA. There was faint enhancement in 2 cases with cerebral infarction of about 24h duration and obvious enhancement in all cases in the subacute stage. Compared with enhanced CT, MR using Gd-DTPA demonstrated more obvious enhancement of infarcted areas. MR enhancement using Gd-DTPA showed a gradual increase and the accumulated Gd-DTPA in infarcted areas slowly diffused to the periphery. MR enhancement with Gd-DTPA is similar to that of enhanced CT, but may be more sensitive in the detection of blood brain barrier breakdown.
Similar content being viewed by others
References
Brant-Zawadzki M, Norman D, Newton TH, Kelly WM, Kjos B, Mills CM, Dillon W, Sobel D, Crooks LE (1984) Magnetic resonance imaging of the brain: the optimal screening technique. Radiology 152: 71–77
Bydder GM, Steiner RE, Young IR, Hall AS, Thomas DJ, Marshall J, Pallis CA, Legg NJ (1982) Clinical NMR imaging of the brain: 140 cases. AJR 139:215–236
Bradley WG Jr, Waluch V, Yadley RA, Wycoff RR (1984) Comparison of CT and MR in 400 patients with disease of brain and cervical spinal cord. Radiology 152:695–702
Bryan RN, Willcott MR, Schneiderrs NJ, Frod JJ, Derman HS (1983) Nuclear magnetic resonance evaluation of stroke. Radiology 149: 189–192
Sipponen JT, Kaste M, Ketonen L, Sepponen RE, Katevuo K, Sivula A (1983) Serial nuclear magnetic resonance (NMR) imaging in patients with cerebral infarction. J Comput Assist Tomogr 7 (4): 585–589
Sipponen JT (1984) Visualization of brain infarction with nuclear magnetic resonance imaging. Neuroradiology 26: 590–594
Brant-Zawadzki M, Pereira B, Weinstein P, Moore S, Kucharczyk W, Berry I, McNamara M, Dergin N (1986) MR imaging of acute experimental ischemia in cats. AJNR 7: 7–11
Carr DH, Brown J, Bydder GM, Steiner RE, Weinmann HJ, Speck U, Hall AS, Young IR (1984) Gadolinium-DTPA as a contrast agent in MRI: initial clinical experience in 20 patients. AJR 143: 215–224
Claussen C, Laniado M, Schorner W, Neindorf HP, Weinman HJ, Fiegler W, Felix R (1985) Gadolinium-DTPA in MR imaging of glioblastomas and intracranial metastases. AJNR 6: 669–674
Graif M, Bydder GM, Steiner RE, Niendorf P, Thomas DGT. Young IR (1985) Contrant enhanced MR imaging of malignant brain tumors. AJNR 6: 855–862
Runge VM, Clanton JA, Price AC, Herzer WA, Allen JH, Partein CL, James AE Jr (1985) Evaluation of contrast-enhanced MR imaging in a brain-abscess model. AJNR 6: 139–149
McNamara MT, Brant-Zawadzki M, Berry I, Pereira B, Weinstein P, Derugin N, Moore S, Kucharczyk W, Brasch RC (1986) Acute experimental cerebral ischemia: MR enhancement using Gd-DTPA. Radiology 158: 701–705
Schorner W, Laniado M, Niendorf HP, Schubert C, Felix R (1986) Time-dependent changes in image contrast in brain tumors after gadolinium-DTPA. AJNR 7: 1013–1020
Carr DH, Brown J, Bydder GM, Weinmann HJ, Speck U, Thomas DJ, Young IR (1984) Clinical use of intravenous gadolinium-DTPA as a contrast agent in NMR imaging of cerebral tumors. Lancet 1: 484–486
Felix R, Schorner W, Laniado M, Niendorf HP, Claussen C, Fiegler W, Speck U (1985) Brain tumors: MR imaging with Gadolinium-DTPA. Radiology 156: 681–688
Virapongse C, Mancuso A, Quisling R (1986) Human brain infarcts: Gd-DTPA-enhanced MR imaging. Radiology 161: 785–794
Zimmerman V, Hossmann KA (1975) Resuscitation of the monkey brain after one hour's complete ischemia. II. Brain water and electrolytes. Brain Res 85: 1–11
O'Brien MD (1979) Ischemic cerebral edema: a review. Stroke 10: 623–628
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Imakita, S., Nishimura, T., Naito, H. et al. Magnetic resonance imaging of human cerebral infarction: Enhancement with Gd-DTPA. Neuroradiology 29, 422–429 (1987). https://doi.org/10.1007/BF00341737
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00341737