Summary
Fanconi's anemia, a hereditary autosomal disease with chromosomal instability, elevated incidence of cancer and clinical symptoms is accompanied by a DNA repair deficiency. Fibroblasts from patients with Fanconi's anemia were found to be impaired in the DNA repair of UV damage. Nucleoid decondensation and recondensation after UV irradiation were less efficient in fibroblasts from patients with Fanconi's anemia than in those from a healthy proband. These data confirm our earlier findings that DNA ligase is deficient in Fanconi's anemia.
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Communicated by K. Isono
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Schwaiger, H., Hirsch-Kauffmann, M. & Schweiger, M. UV-Repair is impaired in fibroblasts from patients with Fanconi's anemia. Mol Gen Genet 185, 454–456 (1982). https://doi.org/10.1007/BF00334139
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DOI: https://doi.org/10.1007/BF00334139