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Projections of the bed nucleus of the stria terminalis to the mesencephalon, pons, and medulla oblongata in the cat

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Summary

Injections of HRP in the nucleus raphe magnus and adjoining medial reticular formation in the cat resulted in many labeled neurons in the lateral part of the bed nucleus of the stria terminalis (BNST) but not in the medial part of this nucleus. HRP injections in the nucleus raphe pallidus and in the C2 segment of the spinal cord did not result in labeled neurons in the BNST. Injections of 3H-leucine in the BNST resulted in many labeled fibers in the brain stem. Labeled fiber bundles descended by way of the medial forebrain bundle and the central tegmental field to the lateral tegmental field of pons and medulla. Dense BNST projections could be observed to the substantia nigra pars compacta, the ventral tegmental area, the nucleus of the posterior commissure, the PAG (except its dorsolateral part), the cuneiform nucleus, the nucleus raphe dorsalis, the locus coeruleus, the nucleus subcoeruleus, the medial and lateral parabrachial nuclei, the lateral tegmental field of caudal pons and medulla and the nucleus raphe magnus and adjoining medial reticular formation. Furthermore many labeled fibers were present in the solitary nucleus, and in especially the peripheral parts of the dorsal vagal nucleus. Finally some fibers could be traced in the marginal layer of the rostral part of the caudal spinal trigeminal nucleus. These projections appear to be virtually identical to the ones derived from the medial part of the central nucleus of the amygdala (Hopkins and Holstege 1978). The possibility that the BNST and the medial and central amygdaloid nuclei must be considered as one anatomical entity is discussed.

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Abbreviations

AA:

anterior amygdaloid nucleus

AC:

anterior commissure

ACN:

nucleus of the anterior commissure

ACO:

cortical amygdaloid nucleus

AL:

lateral amygdaloid nucleus

AM:

medial amygdaloid nucleus

APN:

anterior paraventricular thalamic nucleus

AQ:

cerebral aqueduct

BC:

brachium conjunctivum

BIC:

brachium of the inferior colliculus

BL:

basolateral amygdaloid nucleus

BNSTL:

lateral part of the bed nucleus of the stria terminalis

BNSTM:

medial part of the bed nucleus of the stria terminalis

BP:

brachium pontis

CA:

central nucleus of the amygdala

Cd:

caudate nucleus

CI:

inferior colliculus

CL:

claustrum

CN:

cochlear nucleus

CP:

posterior commissure

CR:

corpus restiforme

CSN:

superior central nucleus

CTF:

central tegmental field

CU:

cuneate nucleus

D:

nucleus of Darkschewitsch

EC:

external cuneate nucleus

F:

fornix

G:

gracile nucleus

GP:

globus pallidus

HL:

lateral habenular nucleus

IC:

interstitial nucleus of Cajal

ICA:

internal capsule

IO:

inferior olive

IP:

interpeduncular nucleus

LC:

locus coeruleus

LGN:

lateral geniculate nucleus

LP:

lateral posterior complex

LRN:

lateral reticular nucleus

MGN:

medial geniculate nucleus

MLF:

medial longitudinal fascicle

NAdg:

dorsal group of nucleus ambiguus

NPC:

nucleus of the posterior commissure

nV:

trigeminal nerve

nVII:

facial nerve

OC:

optic chiasm

OR:

optic radiation

OT:

optic tract

P:

pyramidal tract

PAG:

periaqueductal grey

PC:

cerebral peduncle

PO:

posterior complex of the thalamus

POA:

preoptic area

prV:

principal trigeminal nucleus

PTA:

pretectal area

Pu:

putamen

PUL:

pulvinar nucleus

R:

red nucleus

RF:

reticular formation

RM:

nucleus raphe magnus

RP:

nucleus raphe pallidus

RST:

rubrospinal tract

S:

solitary nucleus

SC:

suprachiasmatic nucleus

SCN:

nucleus subcoeruleus

SI:

substantia innominata

SM:

stria medullaris

SN:

substantia nigra

SO:

superior olive

SOL:

solitary nucleus

SON:

supraoptic nucleus

spV:

spinal trigeminal nucleus

spVcd:

spinal trigeminal nucleus pars caudalis

ST:

stria terminalis

TRF:

retroflex tract

VC:

vestibular complex

VTA:

ventral tegmental area of Tsai

III:

oculomotor nucleus

Vm:

motor trigeminal nucleus

VI:

abducens nucleus

VII:

facial nucleus

Xd:

dorsal vagal nucleus

XII:

hypoglossal nucleus

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Authors and Affiliations

  1. Department of Anatomy II, (HB13), Medical Faculty, Erasmus University, Postbus 1738, NL-3000, DR Rotterdam, The Netherlands

    G. Holstege, L. Meiners & K. Tan

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  1. G. Holstege
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  2. L. Meiners
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  3. K. Tan
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Holstege, G., Meiners, L. & Tan, K. Projections of the bed nucleus of the stria terminalis to the mesencephalon, pons, and medulla oblongata in the cat. Exp Brain Res 58, 379–391 (1985). https://doi.org/10.1007/BF00235319

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