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Interaction Between Innate Lymphoid Cells and the Nervous System

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Innate Lymphoid Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1365))

Abstract

The interaction between the immune system and the nervous system remains an intriguing enigma. Recent studies indicate that innate lymphoid cells (ILCs), a unique family of innate effector cells, participate in intense cross talk with the nervous system. In the mucosal barrier sites, ILCs have been found to co-localize with neurons, nerves, glial cell projectors, and neuroendocrine cells. The cross talk between ILCs and peripheral nervous system orchestrates mucosal homeostasis and immunity. In addition, the barrier tissues of the central nervous system (CNS) also provide conductive microenvironment for ILC development and maintenance. Activities of CNS-associated ILCs impact the outcome of various CNS disorders. In this chapter, we review and discuss the intricate and bidirectional interaction between ILCs and nervous system.

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Authors and Affiliations

  1. Department of Immunology & Microbial Disease, Albany Medical College, Albany, NY, USA

    Yuanyue Zhang, Rachel Grazda & Qi Yang

  2. Rutgers Child Health Institute of New Jersey, New Brunswick, NJ, USA

    Rachel Grazda

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  1. Yuanyue Zhang
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  2. Rachel Grazda
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Correspondence to Qi Yang .

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  1. Program in Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    **ao-Hong Sun

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Zhang, Y., Grazda, R., Yang, Q. (2022). Interaction Between Innate Lymphoid Cells and the Nervous System. In: Sun, XH. (eds) Innate Lymphoid Cells. Advances in Experimental Medicine and Biology, vol 1365. Springer, Singapore. https://doi.org/10.1007/978-981-16-8387-9_9

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