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The Structure of the Periostin Gene, Its Transcriptional Control and Alternative Splicing, and Protein Expression

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Periostin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1132))

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Abstract

Although many studies have described the role of periostin in various diseases, the functions of periostin derived from alternative splicing and proteinase cleavage at its C-terminus remain unknown. Further experiments investigating the periostin structures that are relevant to diseases are essential for an in-depth understanding of their functions, which would accelerate their clinical applications by establishing new approaches for curing intractable diseases. Furthermore, this understanding would enhance our knowledge of novel functions of periostin related to stemness and response to mechanical stress .

Material in this chapter has been adapted from Kudo (2017) [48] with permission.

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Acknowledgements

I thank my collaborators involved in the periostin project for providing figures.

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  1. International Frontier, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan

    Akira Kudo

  2. School of Dentistry, Showa University, Tokyo, Japan

    Akira Kudo

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Correspondence to Akira Kudo .

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    Akira Kudo

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Kudo, A. (2019). The Structure of the Periostin Gene, Its Transcriptional Control and Alternative Splicing, and Protein Expression. In: Kudo, A. (eds) Periostin. Advances in Experimental Medicine and Biology, vol 1132. Springer, Singapore. https://doi.org/10.1007/978-981-13-6657-4_2

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