Abstract
Control of bacterial diseases has, for many years, been dependent on the use of antibiotics. Due to the high levels of efficacy of antibiotics in the past other disease control options have, to a large extent, been neglected. Mankind is now facing an increasing problem with antibiotic resistance. In an effort to retain some antibiotics for human use, there are moves afoot to limit or even ban the use of antibiotics in animal production. The use of antibiotics as growth promoters have been banned in the European Union and the USA. The potential ban on the use of antibiotics to treat diseases in production animals creates a dilemma for man—suffer significant problem with bacterial infection or suffer from a severe shortage of food! There are other options for the control of bacterial diseases. These include vaccine development, bacteriophage therapy, and improved biosecurity. Vaccine development against bacterial pathogens, particularly opportunistic pathogens, is often very challenging, as in many cases the molecular basis of the virulence is not always clearly understood. This is particularly true for Escherichia coli. Biosecurity (disinfection) has been a highly neglected area in disease control. With the ever-increasing problems with antibiotic resistance—the focus should return to improvements in biosecurity. As with antibiotics, bacteria also have mechanisms for resistance to disinfectants. To ensure that we do not replace one set of problems (increasing antibiotic resistance) with another (increasing resistance to disinfectants) we need to fully understand the modes of action of disinfectants and how the bacteria develop resistance to these disinfectants. Molecular studies have been undertaken to relate the presence of QAC resistance genes in bacteria to their levels of sensitivity to different generations of QAC-based products. The mode of action of QAC on bacteria has been studied using NanoSAM technology, where it was revealed that the QAC causes disruption of the bacterial cell wall and leaking of the cytoplasm out of the cells. Our main focus is on the control of bacterial and viral diseases in the poultry industry in a post-antibiotic era, but the principles remain similar for disease control in any veterinary field as well as in human medicine.
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References
Bragg RR, Kock L (2013) Nanomedicine and infectious diseases. Expert Rev Anti-infect Ther 11:359–361
Feighner SD, Dashkevicz MP (1987) Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity. Appl Environ Microbiol 53:331–336
Gilbert P, Moore LE (2005) Cationic antiseptics: diversity of action under a common apithet. J Appl Microbiol 99:703–715
Herikstad H, Hayes PS, Hogan J, Floyd P, Snyder L, Angulo FJ (1997) Ceftriaxone-resistant Salmonella in the united states. J Paediatr Infect Dis 9:904–905
Wiuff C, Madsen M, Baggesen DL, Aarestrup FM (2000) Quinolone resistance among Salmonella enterica from cattle, broilers, and swine in Denmark. Microbiol Drug Resist 6:11–17
White DG, McDermott PF (2001) Biocides, drug resistance and microbial evolution. Curr Opinion Microbiol 4:313–317
Rao GO (1998) Risk factors for the spread of antibiotic-resistant bacteria. Drugs 55:323–330
Feinman SE (1999) Antibiotics in animal feeds – drug resistance revisited. ASM News 64:24–29
Georgala DL (1999) Report on microbial antibiotic resistance in relation to food safety. Advisory committee on the microbiological safety of food (ACMSF). HMSO, London
Magee JT, Pritchard EL, Fitzgerald KA, Dunstan FDJ, Howard AJ (1999) Antibiotic prescribing and antibiotic resistance in community practice: retrospective study, 1996–1998. B Med J 319:1239–1240
Dixon B (2000) Antibiotics as growth promoters: risks and alternatives. ASM News 66:264–265
Casewell M, Friis C, Marco E, McMullin P, Phillips I (2003) The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. J Antimicrob Chemother 53:159–161
Joerger RD (2003) Alternative to antibiotics: bacteriocins, antimicrobial peptides and bacteriophages. Poul Sci 82:640–647
Boyd EF, Brüssow H (2002) Common themes among bacteriophage-encoded virulence factors and diversity among the bacteriophages involved. Trends Microbiol 10:521–529
Barnes HJ, Glisson JR, Fadly AM, McDougald LR, Swayne D (2003) Colibacillosis. In: Saif YM (ed) Diseases of Poultry, 11th edn. Iowa State University Press, Ames, p 631
Delicato ER, de Brito BG, Gaziri LC, Vidotto MC (2003) Virulence-associated genes in Escherichia coli isolates from poultry with colibacillosis. Vet Microbiol 94:97–103
Vandekerchove D, Vandemaele F, Adriaensen C, Zaleska M, Hernalsteens JP, De Baets L et al (2005) Virulence-associated traits in avian Escherichia coli: comparison between isolates from colibacillosis-affected and clinically healthy layer flocks. Vet Microbiol 108:75–87
Van der Westhuizen WA, Bragg RR (2012) Multiplex polymerase chain reaction for screening avian pathogenic Escherichia coli for virulence genes. Avian Path 41:33–40
Rodriguez-Siek KE, Giddings CW, Doetkott C, Johnson TJ, Nolan LK (2005) Characterizing the APEC pathotype. Vet Res 36:241–256
Ewers C, Li G, Wilking H, KieBling S, Alt K, Antà o E et al (2007) Avian pathogenic, uropathogenic, and newborn meningitis-causing Escherichia coli: how closely related are they? Int J Med Microbiol 297:163–176
Johnson TJ, Wannemuehler Y, Doetkott C, Johnson SJ, Rosenberger SC, Nolan LK (2008) Identification of minimal predictors of avian pathogenic Escherichia coli virulence for use as a rapid diagnostic tool. J Clin Microbiol 46:3987–3996
Herren C, Mitra A, Palaniyandi SK, Coleman A, Elankumaran S, Mukhopadhyay S (2006) The barA-uvrY two-component system regulates virulence in avian pathogenic Escherichia coli O78:K80:H9. Infect Immun 74:4900–4909
Rouquet G, Porcheron G, Barra C, Répérant M, Chanteloup NK, Schouler C, Gilot P (2009) A metabolic operon in extraintestinal pathogenic Escherichia coli promotes fitness under stressful conditions and invasion of eukaryotic cells. J Bact 191:4427–4440
Parreira VR, Gyles CL (2003) A novel pathogenicity island integrated adjacent to the thrW tRNA gene of avian pathogenic Escherichia coli encodes a vacuolating autotransporter toxin. Infect Immun 71:5087–5096
Runyen-Janecky LJ, Reeves SA, Gonzales EG, Payne SM (2003) Contribution of the Shigella flexneri sit, iuc and feo iron acquisition systems to iron acquisition in vitro and in cultured cells. Infect Immun 71:1919–1928
Pavelka MS Jr, Wright LF, Silver RP (1991) Identification of two genes, kpsM and kpsT, in region 3 of the polysialic acid gene cluster of Escherichia coli K1. J Bact 173:4603–4610
Mellata M, Dho-Moulin M, Dozois CM, Curtiss R III, Brown PK, Arnè P, Brèe A, Desautels C, Fairbrother JM (2003) Role of virulence factors in resistance of avian pathogenic Escherichia coli to serum and in pathogenicity. Infect Immun 7:536–540
AntĂŁo E, Ewers C, GĂĽrlebeck D, Preisinger R, Homeier T, Li G, Wieler LH (2009) Signature-tagged mutagenesis in a chicken infection model leads to the identification of a novel avian pathogenic Escherichia coli fimbrial adhesin. PLoS One 4:e7796
Bäumler AJ, Norris TL, Lasco T, Voigt W, Reissbrodt R, Rabsch W, Heffron F (1998) IroN, a novel outer membrane siderophore receptor characteristic of Salmonella enterica. J Bact 180:1446–1453
Cavard D, Lazdunski C (1990) Colicin cleavage by ompT protease during both entry into and release from Escherichia coli cells. J Bact 172:648–652
Morales C, Lee MD, Hofacre C, Maurer JJ (2004) Detection of a novel virulence gene and a Salmonella virulence homologue among Escherichia coli isolated from broiler chickens. Foodborne Path Dis 1:160–165
Williams PH, Warner PJ (1980) ColV plasmid-mediated, colicin V-independent iron uptake system of invasive strains of Escherichia coli. Infect Immun 29:411–416
Chuba PJ, Leon MA, Banerkee A, Palchaudhuri S (1989) Cloning and DNA sequence of plasmid determinant iss, coding for increased serum survival and surface exclusion, which has homology with lambda DNA. Mol Gen Gene 216:287–292
Lamarche MG, Dozois CM, Daigle F, Caza M, Curtiss R III, Dubreuil JD, Harel J (2005) Inactivation of pst system reduces the virulence of an avian pathogenic Escherichia coli O78 strain. Infect Immun 73:4138–4145
Johnson TJ, Johnson SJ, Nolan LK (2006) Complete DNA sequence of a ColBM plasmid from avian pathogenic Escherichia coli suggests that it evolved from closely related ColV virulence plasmids. J Bact 188:5975–5983
Li G, Ewers C, Laturnus C, Diehl I, Alt K, Dai J et al (2008) Characterization of a yjjQ mutant of avian pathogenic Escherichia coli (APEC). Microbiology 154:1082–1093
Provence DL, Curtiss R III (1994) Isolation and characterization of a gene involved in hemagglutination by an avian pathogenic Escherichia coli strain. Infect Immun 62:1369–1380
Skyberg JA, Johnson TJ, Johnson JR, Clabots C, Logue CM, Nolan LK (2006) Acquisition of avian pathogenic Escherichia coli plasmids by a commensal E. coli isolate enhances its abilities to kill chicken embryos, grow in human urine, and colonize the murine kidney. Infect Immun 74:6287–6292
Olsen RH, Christensen H, Bisgaard M (2012) Comparative genomics of multiple plasmids from APEC associated with clonal outbreaks demonstrates major similarities and identifies several potential vaccine-targets. Vet Microbiol 158:384–393
Dancer SJ (2011) Hospital cleaning in the 21st century. Eur J Clin Microbiol Infect Dis 30:1473–1481
Lister J (1867) On the antiseptic principle in the practice of surgery. Brit Med J 2(351):245–260
Guggenbichler JP, Assadian O, Boeswald M, Kamer A (2011) Incidence and clinical impact of nosocomal infections associated with implantable biomaterials – catheters, ventilator-associated pneunmonia, urinary tract infections. GMs Krankenhhyg Interdiszip 6 Doc 18. doi:10.3205/dgkh000175
Ecker DJ, Carroll KC (2005) Investments in high-payoff technologies could reduce toll of infections. ASM News 71:576–581
Lin YE, Stout JE, Yu VL (2011) Prevention of hospital acquired legionellosis. Curr Opin Infect Dis 24:350–356
Alsubaie S, bin Maither A, Alalmaei W, Al-Shammari AD, Tashkandi M, Somily AM, Alaska A, BinSaeed AA (2013) Determinants of hand hygien noncompliance in intensive care units. Am J Infect Control 41:131–135
Bragg RR (2004) Limitation of the spread and impact of infectious coryza through the use of a continuous disinfection programme. Onderstepoort J Vet Res 71:1–8
Bragg RR, Plumbtree P (2003) Continuous disinfection as a means to control infectious diseases in poultry. Evaluation of a continuous disinfection programme for broilers. Onderstepoort J Vet Res 70:219–229
McDonnell G, Russell AD (1999) Antiseptics and disinfectants: activity, action and resistance. Clin Microbiol Rev 12:147–179
Russell AD (1998) Bacterial resistance to disinfectants: present knowledge and future problems. J Hosp Infect 43:S57–S68
Hegstad K, Langsrud S, Lunestad BT, Scheie AA, Sunde M, Yazdankhah SP (2010) Does the wide use of quaternary ammonium compounds enhance the selection and spread of antimicrobial resistance and thus threaten our health? Microl Drug Resist 16:91–104
White DG, McDermott PF (2001) Biocides, drug resistance and microbial evolution. Curr Opin Microbiol 4:313–317
Buffet-Bataillon S, Tattevin P, Bonnaure-Mallet M, Jolivet-Gougeon A (2012) Emergence of resistance to antimicrobial agents: the role of quaternary ammonium compounds – a critical review. Int J Antimicrob Agents 39:381–389
Ioannou CJ, Hanlon GW, Denyer SP (2007) Action of disinfectant quaternary ammonium compounds against Staphylococcus aureus. Antimicrob Agents Chemother 51:296–306
Bjorland J, Steinum T, Kvitle B, Waage S, Sunde M, Heir E (2005) Widespread distribution of disinfectant resistance genes among Staphylococci of bovine and caprine origin in Norway. J Clin Microbiol 43:4363–4368
Heir E, Sundheim G, Holck AL (1999) Identification and characterization of quaternary ammonium compound resistant Staphylococci from the food industry. Int J Food Microbiol 48:211–219
Langsrud S, Sundheim G, Brogman-Stahsen R (2003) Intrinsic and acquired resistance to quaternary ammonium compounds in food-related Pseudomonas spp. J Appl Microbiol 95:874–882
Hassan K A, Baltzer S A, Paulsen I T, Brown M (2010) Pum** out biocides-cause for concern. Microbiol Aust November: 178–181
Piddock LJV (2006) Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev 19:382–402
Kumar A, Schweizer HP (2005) Bacterial resistance to antibiotics: active efflux and reduced uptake. Adv Drug Del Rev 57:1486–1513
Putman M, van Veen HW, Konings WN (2000) Molecular properties of bacterial multidrug transporters. Microbiol Mol Biol Rev 64:672–693
Carson RT, Larson E, Levy SB, Marshall BM, Aiello AE (2008) Use of antibacterial consumer products containing quaternary ammonium compounds and drug resistance in the community. J Antimicrob Chemother 62:1160–1162
Gillings MR, Xuejun D, Hardwick SA, Holley MP, Stokes HW (2009) Gene cassettes encoding resistance to quaternary ammonium compounds: a role in the origin of clinical class 1 integrons? ISME J 3:209–215
Paulsen IT, Brown MH, Sunstan SJ, Skurray RA (1995) Molecular characterization of the Staphylococcal multidrug resistance export protein QacC. J Bacteriol 177:2827–2833
Campanac C, Pineau l, Payard A, Baziard-Mouysset G, Roques C (2002) Interactions between biocide cationic agents and bacterial biofilms. Antimicrob Agents Chemother 46:1469–1474
Swart CW, Pohl CH, Kock JLF (2013) Auger-Architectomics: introducing a new nanotechnology to infectious disease. In: Adhikari, Thapa (eds) Advances in Experimental Medicine, Biology. Infectious Diseases and Nanomedicine I, vol 807, Chapter 1
Calvo-Barrio L, PĂ©rez-RodrĂguez A, Alvarez-Garcia J, Romano- RodrĂguez A, Barcones B, Morante JR, Siemer K, Luck I, Klenk R, Scheer R (2001) Combined in-depth scanning auger microscopy and raman scattering characterisation of CuInS2 polycrystalline films. Vacuum 63:315–321
Hochella MF, Harris DW, Turner AM (1986) Scanning auger microscopy as a high-resolution microprobe for geologic materials. Am Miner 71:1247–1257
Bragg RR, van der Westhuizen W, Lee J-Y, Coetsee E, Boucher CE (2013) Bacteriophages as potential treatment option for antibiotic resistant bacteria. In: Adhikari, Thapa (eds) Advances in Experimental Medicine, Biology. Infectious Diseases and Nanomedicine I, vol 807, Chapter 7
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Bragg, R., Jansen, A., Coetzee, M., van der Westhuizen, W., Boucher, C. (2014). Bacterial Resistance to Quaternary Ammonium Compounds (QAC) Disinfectants. In: Adhikari, R., Thapa, S. (eds) Infectious Diseases and Nanomedicine II. Advances in Experimental Medicine and Biology, vol 808. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1774-9_1
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