Abstract
This paper is a survey of our recent work concerning the dynamics of the association of trypsin and chymotrypsin with the pancreatic trypsin inhibitors, that is, the Kunitz inhibitor (PTI)1 and the Kazal (secretory) inhibitor (PSTI).
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Abbreviations
- PTI:
-
virgin basic pancreatic trypsin inhibitor (Kunitz inhibitor)
- R*PTI:
-
basic pancreatic trypsin inhibitor selectively reduced at S-S 14-38
- RCAM*PTI:
-
carboxamidomethylated R*PTI
- RAE*PTI:
-
aminoethylated R*PTI
- PTI*GL15 :
-
PTI selectively guanidinated at Lysine 15
- PSTI:
-
pancreatic secretory trypsin inhibitor (Kazal inhibitor)
- RCOM*-trypsin:
-
trypsin selectively reduced and carboxymethylated at S-S 179-203
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Lazdunski, M., Vincent, JP., Schweitz, H., Péron-Renner, M., Pudles, J. (1974). The Mechanism of Association of Trypsin (or Chymotrypsin) with the Pancreatic Trypsin Inhibitors (Kunitz and Kazal) Kinetics and Thermodynamics of the Interaction. In: Fritz, H., Tschesche, H., Greene, L.J., Truscheit, E. (eds) Proteinase Inhibitors. Bayer-Symposium, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87966-1_47
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