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The Influence of Pre- and Postoperative Polydrug Chemotherapy on Bone Healing in Tumor Surgery

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Bone Transplantation

Abstract

Combination chemotherapy in the treatment of most primary malignant bone tumors was introduced in the early 1970s, and it was expected that these highly potent drugs would have a negative effect on bone healing, particularly in cases of bone transplantation. Experimental investigations by Sauer et al. [3] on the influence of cyclophosphamide on bone healing and those by Burchardt et al. [1] on the influence of adriamycin and methotrexate on bone healing have confirmed this. In the literature there are until now no clinical results of bone healing after osteosynthesis or bone transplantation in patients under polydrug chemotherapy.

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References

  1. Burchardt H, Glowczewskie FP, Enneking WF (1983) The effect of adriamycin and methotrexate on the repair of segmental cortical autografts in dogs. J Bone Joint Surg [Am] 65: 103

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  2. Jürgens H et al. (1985) Die cooperative Ewing-Sarkom Studie CESS 81 der GPO — Analyse nach 4 Jahren. Klin Pädiatr 197: 225

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  3. Sauer HD, Sommer-Tsilenis E, Borchers D, Schmidt H (1982) Die Beeinflussung der Knochenbruchheilung durch das Zytostatikum Zyklophosphamid. Z Orthop 120: 783

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  4. Winkler K (1986) Zur Chemotherapie des Osteosarkoms. 9 Jahre kooperative Osteosarkomstudie (COSS) der GPO. Onkol Forum 3: 1

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Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, University of Düsseldorf, Düsseldorf, Germany

    W. Winkelmann

  2. Department of Pediatric Oncology and Hematology, University of Düsseldorf, Düsseldorf, Germany

    H. Jürgens

Authors
  1. W. Winkelmann
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  2. H. Jürgens
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Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Orthopädische Chirurgie, Inselspital, CH-3010, Bern, Switzerland

    Max Aebi

  2. Departement für Chirurgie, Kantonsspital Basel, Spitalstr. 21, CH-4031, Basel, Switzerland

    Pietro Regazzoni

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© 1989 Springer-Verlag, Berlin Heidelberg

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Winkelmann, W., Jürgens, H. (1989). The Influence of Pre- and Postoperative Polydrug Chemotherapy on Bone Healing in Tumor Surgery. In: Aebi, M., Regazzoni, P. (eds) Bone Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83571-1_75

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  • DOI: https://doi.org/10.1007/978-3-642-83571-1_75

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83573-5

  • Online ISBN: 978-3-642-83571-1

  • eBook Packages: Springer Book Archive

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