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Early Mortality Due to Ventricular Fibrillation, and the Vulnerability of the Heart Following Acute Experimental Coronary Occlusion: Possible Mechanisms and Pharmacological Prophylaxis

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The Arterial System

Abstract

Ventricular fibrillation (VF) is by far and away the most common cause of early mortality in patients with acute myocardial infarction [12, 13]. This also applies equally to acute experimental coronary occlusion [12, 13]. Early mortality within the first 24 h attains a maximum in the 1st h and then drops exponentially. The mean interval between the onset of symptoms and sudden death is reported as 21 min [12, 13]. In experimental cardiology, we distinguish between two characteristic phases of arrhythmias following acute one-step coronary ligation [9]: an initial early phase lasting 20–30 min immediately following ligation and a second phase of arrhythmias after an interval of 6–10 h with few extrasystoles; this second phase lasts for a period of 24–48 h. The present study is an investigation of the first phase of arrhythmias described by Harris [9].

Supported by the Landesamt f. Wissenschaft u. Froschung, Düsseldorf, FRG.

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Authors and Affiliations

  1. Institute of Pathophysiology, University Essen (GHS), Hufelandstraße 55, D-43 Essen 1, Fed. Rep. Germ.

    W. Meesmann, V. Wiegand, U. Menken, W. Komhard & U. Rehwald

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  1. W. Meesmann
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  2. V. Wiegand
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  3. U. Menken
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  4. W. Komhard
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  5. U. Rehwald
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Editors and Affiliations

  1. Institut für Physiologie und Kardiologie, Universität Erlangen-Nürnberg, D-8520, Erlangen, Waldstraße 6, Germany

    R. D. Bauer  & R. Busse  & 

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Meesmann, W., Wiegand, V., Menken, U., Komhard, W., Rehwald, U. (1978). Early Mortality Due to Ventricular Fibrillation, and the Vulnerability of the Heart Following Acute Experimental Coronary Occlusion: Possible Mechanisms and Pharmacological Prophylaxis. In: Bauer, R.D., Busse, R. (eds) The Arterial System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67020-6_26

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  • DOI: https://doi.org/10.1007/978-3-642-67020-6_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08897-4

  • Online ISBN: 978-3-642-67020-6

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