Zusammenfassung
Wachstum ist ein Prozess, der durch Zellvermehrung, Zellvergrößerung und kontrollierten Zelltod einen Zuwachs an messbarer Größe herbeiführt. Dieser Prozess ist kontrolliert, damit die erzielten Größen einen bestimmten vom Organismus als sinnvoll erachteten Rahmen nicht überoder unterschreiten. Das menschliche Wachstum ist individuell verschieden und wird durch die genetische Ausstattung, durch Signalsysteme (die wesentlich vom Genotyp abhängen) sowie durch Ernährung und andere Umweltfaktoren kontrolliert. Die Zunahme an Körperhöhe ist kein linearer Prozess, es gibt verschiedene endogen getriggerte Phasen schnellen und langsamen Wachstums, die wiederum subtil moduliert werden durch andere Faktoren wie z. B. die Jahreszeit mit dem winterlichen Absinken der Wachstumsgeschwindigkeit.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literatur
Aksglaede L, Skakkebaek NE, Juul A (2008) Abnormal Sex Chromosome Constitution and Longitudinal Growth: Serum Levels of Insulin-Like Growth Factor (IGF)-I, IGF Binding Protein-3, Luteinizing Hormone, and Testosterone in 109 Males with 47,XXY, 47,XYY, or Sex-Determining Region of the Y Chromosome (SRY)-Positive 46,XX Karyotypes. J Clin Endocrinol Metab 93: 169–176
Aoki Y, Niihori T, Narumi Y, Kure S, Matsubara Y (2008) The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders. Hum Mutat 29(8): 992–1006
Bayley N, Pinneau SR (1952) Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr 40: 423–441
Binder G, Koch A, Wajs E, Ranke MB (1995) Nested polymerase chain reaction study of 53 cases with Turner’s syndrome: is cytogenetically undetected Y mosaicism common? J Clin Endocrinol Metab 80(12): 3532–3536
Binder G, Grauer ML, Wehner AV, Wehner F, Ranke MB (1997) Outcome in tall stature. Final height and psychological aspects in 220 patients with and without treatment. Eur J Pediatr 156: 905–910
Binder G, Nagel BH, Ranke MB, Mullis PE (2002) Isolated GH deficiency (IGHD) type II: imaging of the pituitary gland by magnetic resonance reveals characteristic differences in comparison with severe IGHD of unknown origin. Eur J Endocrinol 147(6): 755–760
Binder G, Ranke MB, Martin DD (2003) Auxology is a valuable instrument for the clinical diagnosis of SHOX haploinsufficiency in school-age children with unexplained short stature. J Clin Endocrinol Metab 88(10): 4891–4896
Binder G, Renz A, Martinez A et al. (2004a) SHOX haploinsufficiency and Leri-Weill dyschondrosteosis: prevalence and growth failure in relation to mutation, sex, and degree of wrist deformity. J Clin Endocrinol Metab 89(9): 4403–4408
Binder G, Bosk A, Gass M, Ranke MB, Heidemann PH (2004b) Insulin tolerance test causes hypokalaemia and can provoke cardiac arrhythmias.Horm Res 62: 84–87
Binder G, Neuer K, Ranke MB, Wittekindt NE (2005) PTPN11 mutations are associated with mild growth hormone resistance in individuals with Noonan syndrome. J Clin Endocrinol Metab 90: 5377–5381
Binder G, Brämswig JH, Kratzsch J, Pfäffle R, Wölfle J (2008) S2-Leitlinie. Diagnostik des Wachstumshormonmangels im Kindes-und Jugendalter. http://www.awmf-leitlinien.de
Blum WF, Crowe BJ, Quigley CA et al. SHOX Study Group (2007). Growth hormone is effective in treatment of short stature associated with short stature homeobox-containing gene deficiency: Twoyear results of a randomized, controlled, multicenter trial. J Clin Endocrinol Metab 92(1): 219–228
Carel JC, Elie C, Ecosse E et al. (2006) Self-esteem and social adjustment in young women with Turner syndrome—influence of pubertal management and sexuality: population-based cohort study. J Clin Endocrinol Metab 91(8): 2972–2979
Cutfield WS, Wilton P, Bennmarker H, Albertsson-Wikland K, Chatelain P, Ranke MB, Price DA (2000) Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment. Lancet 355 (9204)610–613
Darendeliler F, Karagiannis G, Wilton P (2007) Headache, idiopathic intracranial hypertension and slipped capital femoral epiphysis during growth hormone treatment: a safety update from the KIGS database. Horm Res 68 (Suppl 5): 41–47
Darzy KH, Aimaretti G, Wieringa G, Gattamaneni HR, Ghigo E, Shalet SM (2003) The usefulness of the combined growth hormone (GH)-releasing hormone and arginine stimulation test in the diagnosis of radiation-induced GH deficiency is dependent on the post-irradiation time interval. J Clin Endocrinol Metab 88(1): 95–102
Ergun-Longmire B, Mertens AC, Mitby P, Qin J, Heller G, Shi W, Yasui Y, Robison LL, Sklar CA (2006) Growth hormone treatment and risk of second neoplasms in the childhood cancer survivor. J Clin Endocrinol Metab 91(9): 3494–3498
Gordon K (1997) Pediatric pseudotumor cerebri: descriptive epidemiology. Can J Neurol Sci 24(3): 219–221
Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hands and wrists, 2nd edn. Stanford University Press, Stanford
Grote FK, van Dommelen P, Oostdijk W, de Muinck Keizer-Schrama SM, Verkerk PH, Wit JM, van Buuren S. (2008) Develo** evidencebased guidelines for referral for short stature. Arch Dis Child Mar 93(3): 212–217
Hankinson SE, Willett WC, Colditz GA et al. (1998) concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 351 (9113): 1393–1396
Hauffa BP, Lehmann N, Bettendorf M et al. (2004) Central reassessment of GH concentrations measured at local treatment centers in children with impaired growth: consequences for patient management. Eur J Endocrinol 150: 291–297
Karlberg J (1989) A biologically-oriented mathematical model (ICP) for human growth. Acta Paediatr Scand Suppl 350: 70–94
LaFranchi SH, Lippe BM, Kaplan SA (1977) Hypoglycemia during testing for growth hormone deficiency. J Pediatr 90(2): 244–245
Largo RH, Prader A (1983a) Pubertal development in Swiss girls. Helv Paediatr Acta 38(3): 229–343
Largo RH, Prader A (1983b) Pubertal development in Swiss boys. Helv Paediatr Acta 38(3): 211–228
Lehmann CL, Arons RR, Loder RT, Vitale MG (2006) The epidemiology of slipped capital femoral epiphysis: an update. J Pediatr Orthop 26(3): 286–290
Lemcke B, Zentgraf J, Behre HM, Kliesch S, Bramswig JH, Nieschlag E (1996) Long-term effects on testicular function of high-dose testosterone treatment for excessively tall stature. J Clin Endocrinol Metab 81(1): 296–301
Lettre G, Jackson AU, Gieger C et al. (2008) Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 40(5): 584–591
MacFarlane CE, Brown DC, Johnston LB et al. (2001) Growth hormone therapy and growth in children with Noonan’s syndrome: results of 3 years’ follow-up. J Clin Endocrinol Metab 86: 1953–1956
Marin G, Domené HM, Barnes KM, Blackwell BJ, Cassorla FG, Cutler GB Jr (1994) The effects of estrogen priming and puberty on the GH hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys. J Clin Endocrinol Metab 79: 537–541
Martin DD, Deusch D, Schweizer R, Binder G, Thodberg HH, Ranke MB (2009) Clinical application of automated Greulich-Pyle bone age determination in children with short stature. Pediatr Radiol 39(6): 598–607
Molina S, Paoli M, Camacho N, Arata-Bellabarba G, Lanes R (2008) Is testosterone and estrogen priming prior to clonidine useful in the evaluation of the growth hormone status of short peripubertal children? J Pediatr Endocrinol Metab 21: 257–266
Mortier GR (2001) The diagnosis of skeletal dysplasias: a multidisciplinary approach. Eur J Radiol 40: 161–167
Odink RJ, Gerver WJ, Heeg M, Rouwé CW, van Waarde WM, Sauer PJ (2006) Reduction of excessive height in boys by bilateral percutaneous epiphysiodesis around the knee. Eur J Pediatr 165(1): 50–54
OMIM (2008) http://www.ncbi.nlm.mih.gov/omim
Osio D, Dahlgren J, Albertsson Wikland K, Westphal O (2005) Improved final height with long-term growth hormone treatment in Noonan syndrome. Acta Paediatr 94: 1232–1237
Ranke MB (1996) Towards a consensus on the definition of idiopathic short stature. Horm Res 45 (Suppl 2): 64–66
Ranke MB, Saenger P (2001) Turner’s syndrome. Lancet 358 (9278): 309–314
Ranke MB, Heidemann P, Knupfer C, Enders H, Schmaltz AA, Bierich JR (1988) Noonan syndrome: growth and clinical manifestations in 144 cases. Eur J Pediatr 148(3): 220–227
Rao E, Weiss B, Fukami M et al. (1997) Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat Genet 16(1): 54–63
Rikken B, Wit J (1992) Prepubertal height velocity references over a wide age range. Arch Dis Child 67: 1277–1280
Saenger P, Czernichow P, Hughes I, Reiter EO (2007) Small for gestational age: short stature and beyond. Endocr Rev 28(2): 219–251
Schweizer R, Martin DD, Haase M et al. (2007) Similar effects of longterm exogenous growth hormone (GH) on bone and muscle parameters: a pQCT study of GH-deficient and small-for-gestationalage (SGA) children. Bone 41(5): 875–881
Shah AC, Stanhope R, Matthew D (1992) Hazards of pharmacological tests of growth hormone secretion in childhood. BMJ 18;304(6820): 173–174
Shaw AC, Kalidas K, Crosby AH, Jeffery S, Patton MA (2007) The natural history of Noonan syndrome: a long-term follow-up study. Arch Dis Child 92(2): 128–132
Spiliotis BE, August GP, Hung W, Sonis W, Mendelson W, Bercu BB (1984) Growth hormone neurosecretory dysfunction. A treatable cause of short stature. JAMA 251(17): 2223–2230
Stephure DK (2005) Canadian Growth Hormone Advisory Committee. Impact of growth hormone supplementation on adult height in turner syndrome: results of the Canadian randomized controlled trial. J Clin Endocrinol Metab 90(6): 3360–3366
Superti-Furga A, Unger S (2007) Nosology and classification of genetic skeletal disorders: 2006 revision. Am J Med Genet A 143(1): 1–18
Tanner JM (1985) Growth regulation and the genetics of growth. Prog Clin Biol Res 200: 19–32
Tanner JM, Davies P (1985) Clinical longitudinal standards for height and height velocity for North American children. J Pediatr 107: 317–329
Tanner JM, Whitehouse R, Marshall W et al. (1975) Assesment of skeletal maturity and prediction of adult height (TW2 Method). Academic Press, New York
van der Burgt I, Berends E, Lommen E, van Beersum S, Hamel B, Mariman E (1994) Clinical and molecular studies in a large Dutch family with Noonan syndrome. Am J Med Genet 53 (2): 187–191
Van der Eerden BC, Wit JM (2003) Systemic and local regulation of the growth plate. Endocr Rev 24: 782–801
Venn A, Bruinsma F, Werther G et al. (2004) Oestrogen treatment to reduce the adult height of tall girls: long-term effects on fertility. Lancet 364 (9444): 1513–1518
Wit J, van Unen H (1992) Growth of infants with neonatal growth hormone deficiency. Arch Dis Child 67: 920–924
Zadik Z, Chalew SA, Kowarski A (1990) Assessment of GH secretion in normal stature children using 24-hour integrated concentration of GH and pharmacological stimulation. J Clin Endocrinol Metab 71: 932–936
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Binder, G. (2010). Störungen des Wachstums. In: Pädiatrische Endokrinologie und Diabetologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01912-8_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-01912-8_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-01911-1
Online ISBN: 978-3-642-01912-8
eBook Packages: Medicine (German Language)