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Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease

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Cell Biology of Herpes Viruses

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 223))

Abstract

Innate immune responses play a major role in the control of herpes simplex virus (HSV) infections, and a multiplicity of mechanisms have emerged as a result of human evolution to sense and respond to HSV infections. HSV in turn has evolved a number of ways to evade immune detection and to blunt human innate immune responses. In this review, we summarize the major host innate immune mechanisms and the HSV evasion mechanisms that have evolved. We further discuss how disease can result if this equilibrium between virus and host response is disrupted.

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Acknowledgments

We thank Patrick T. Waters and Melanie Trombly for their assistance in preparation of the manuscript. Research in the laboratory of D.M.K. on this topic is supported by NIH grants AI106934, DE023909, and AI098681. MHO is supported by NIAID T32 training grant AI007512.

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Authors and Affiliations

  1. Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA

    Evelyn A. Kurt-Jones

  2. Division of Gastroenterology, Boston Children’s Hospital, Boston, MA, 02115, USA

    Megan H. Orzalli

  3. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, 02115, USA

    David M. Knipe

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  1. Evelyn A. Kurt-Jones
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  3. David M. Knipe
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  1. Institut für Virologie, Freie Universität Berlin, Berlin, Germany

    Klaus Osterrieder

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Kurt-Jones, E.A., Orzalli, M.H., Knipe, D.M. (2017). Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease. In: Osterrieder, K. (eds) Cell Biology of Herpes Viruses. Advances in Anatomy, Embryology and Cell Biology, vol 223. Springer, Cham. https://doi.org/10.1007/978-3-319-53168-7_3

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