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The ATP2B Plasma Membrane Ca2+ ATPase Family: Regulation in Response to Changing Demands of Cellular Calcium Transport

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Regulation of Ca2+-ATPases,V-ATPases and F-ATPases

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 14))

Abstract

The mammalian ATP2B family of plasma membrane calcium ATPases (PMCAs) consists of over 30 members generated from four genes and via complex alternative RNA splicing. Regulation occurs at the level of ATP2B gene transcription, splicing, translation, and posttranslational modification. PMCA isoforms and splice variants vary in their functional properties and are differentially regulated by intrinsic factors such as calmodulin and lipids, as well as by dynamic interaction with a large number of scaffolding and signaling proteins. A major emerging theme is the functional integration of different PMCAs in multiprotein complexes to allow reciprocal cross talk between localized PMCA-mediated Ca2+ control and the function of other members in the complex. The same PMCA isoform may be responsible for bulk calcium export in the cells of one tissue but control the local activity of a signaling microdomain in the cells of another. Regulation of the PMCAs must therefore be understood in the physiological context of the tissues and cells where they are expressed.

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Acknowledgements

I am grateful to M.-A. Strehler-Page for help with the preparation of Fig. 5.1. This work was supported in part by the Mayo Foundation for Medical Research.

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  1. Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA

    Emanuel E. Strehler

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  1. Emanuel E. Strehler
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Correspondence to Emanuel E. Strehler .

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  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Strehler, E.E. (2016). The ATP2B Plasma Membrane Ca2+ ATPase Family: Regulation in Response to Changing Demands of Cellular Calcium Transport. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Ca2+-ATPases,V-ATPases and F-ATPases. Advances in Biochemistry in Health and Disease, vol 14. Springer, Cham. https://doi.org/10.1007/978-3-319-24780-9_5

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