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Animal Behavior Models in the Analysis and Understanding of Anxiolytic Drugs Acting at Serotonin Receptors

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Animal Models in Psychopharmacology

Part of the book series: APS: Advances in Pharmacological Sciences ((APS))

Summary

Behavioral models have been used extensively in the development and evaluation of anxiolytic drugs. The introduction of clinically-effective anxiolytic drugs that appear to function through mechanisms other than those related to benzodiazepine (BZ) compounds has resulted in a critical re-evaluation of traditional models and concepts of anxiety, as well as the introduction of new animal models. This chapter provides an overview and evaluation of current animal behavior models used in the analysis of anxiolytic drugs with a focus on novel anxiolytics acting through serotonin (5-HT) receptor systems.

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Authors and Affiliations

  1. Department of Psychiatry, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland, 20889, USA

    James E. Barrett

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  1. James E. Barrett
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Editors and Affiliations

  1. CNS-Pharmacology, Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands

    B. Olivier  & J. Mos  & 

  2. Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands

    J. L. Slangen

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Barrett, J.E. (1991). Animal Behavior Models in the Analysis and Understanding of Anxiolytic Drugs Acting at Serotonin Receptors. In: Olivier, B., Mos, J., Slangen, J.L. (eds) Animal Models in Psychopharmacology. APS: Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6419-0_3

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  • DOI: https://doi.org/10.1007/978-3-0348-6419-0_3

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6421-3

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