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Rat Pup Ultrasonic Vocalizations: An Ethologically Relevant Behaviour Responsive to Anxiolytics

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Animal Models in Psychopharmacology

Part of the book series: APS: Advances in Pharmacological Sciences ((APS))

Summary

Rat pups emit ultrasonic calls during brief periods of social isolation. These calls are reduced by most clinically anxiolytic compounds and increased by several different classes of anxiogenics. In addition to detecting anxiolytic efficacy, this behaviour may be a useful tool for studying selective aspects of the neurobiology of anxiety. It should be noted however that pharmacologic results with rat pup studies depend on both the ontogeny of the neurochemical system involved and the maturity of various factors affecting pharmacokinetics and pharmacodynamics.

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  1. Laboratory of Clinical Science, National Institute of Mental Health, P.O.Box 289, Poolesville, MD, 20837, USA

    Thomas R. Insel M.D. & James T. Winslow Ph.D.

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  1. CNS-Pharmacology, Duphar B.V., P.O. Box 900, 1380 DA, Weesp, The Netherlands

    B. Olivier  & J. Mos  & 

  2. Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands

    J. L. Slangen

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Insel, T.R., Winslow, J.T. (1991). Rat Pup Ultrasonic Vocalizations: An Ethologically Relevant Behaviour Responsive to Anxiolytics. In: Olivier, B., Mos, J., Slangen, J.L. (eds) Animal Models in Psychopharmacology. APS: Advances in Pharmacological Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6419-0_2

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  • DOI: https://doi.org/10.1007/978-3-0348-6419-0_2

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