Genomic Selection in Animal Breeding Programs

  • Protocol
  • First Online:
Genome-Wide Association Studies and Genomic Prediction

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1019))

Abstract

Genomic selection can have a major impact on animal breeding programs, especially where traits that are important in the breeding objective are hard to select for otherwise. Genomic selection provides more accurate estimates for breeding value earlier in the life of breeding animals, giving more selection accuracy and allowing lower generation intervals. From sheep to dairy cattle, the rates of genetic improvement could increase from 20 to 100 % and hard-to-measure traits can be improved more effectively.

Reference populations for genomic selection need to be large, with thousands of animals measured for phenotype and genotype. The smaller the effective size of the breeding population, the larger the DNA segments they potentially share and the more accurate genomic prediction will be. The relative contribution of information from relatives in the reference population will be larger if the baseline accuracy is low, but such information is limited to closely related individuals and does not last over generations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Protocol
USD 49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Goddard ME (2009) Genomic selection: prediction of accuracy and maximisation of long term response. Genetica 136:245–257

    Article  PubMed  Google Scholar 

  2. Hazel LN (1943) The genetic basis for constructing selection indexes. Genetics 28:476–490

    PubMed  CAS  Google Scholar 

  3. Bijma P (2012) Accuracies of estimated breeding values from ordinary genetic evaluations do not reflect the correlation between true and estimated breeding values in selected populations. J Anim Breed Genet 129:1–14

    Article  PubMed  CAS  Google Scholar 

  4. Lande R, Thompson R (1990) Efficiency of marker-assisted selection in the improvement of quantitative traits. Genetics 124:743–756

    PubMed  CAS  Google Scholar 

  5. James JW (1987) Determination of optimal selection policies. J Anim Breed Genet 104:23–27

    Article  Google Scholar 

  6. Ducrocq V, Quaas RL (1988) Prediction of genetic response to truncation selection across generations. J Dairy Sci 71:2543–2553

    Article  Google Scholar 

  7. Habier D, Fernando RL, Dekkers JCM (2007) The impact of genetic relationship information on genome-assisted breeding values. Genetics 177:2389–2397

    PubMed  CAS  Google Scholar 

  8. Goddard ME, Hayes BJ, Meuwissen TH (2011) Using the genomic relationship matrix to predict the accuracy of genomic selection. J Anim Breed Genet 128:409–421

    Article  PubMed  CAS  Google Scholar 

  9. Clark SA, Hickey JM, Daetwyler HD, van der Werf JHJ (2012) The importance of information on relatives for the prediction of genomic breeding values and the implications for the makeup of reference data sets in livestock breeding schemes. Genet Sel Evol 44:4

    Article  PubMed  Google Scholar 

  10. Daetwyler H, Villanueva B, Woolliams JA, Weedon N (2008) Accuracy of predicting the genetic risk of disease using a genome wide approach. PLoS One 3:e3395. doi:Doi:10.137

    Article  PubMed  Google Scholar 

  11. Cervantes I, Goyache F, Molina A, Valera M, Gutierrez JP (2011) Estimation of effective population size from the rate of co-ancestry in pedigreed populations. J Anim Breed Genet 128:56–63

    Article  PubMed  CAS  Google Scholar 

  12. Kijas JW, Lenstra JA, Hayes BJ et al (2012) Genome-wide analysis of the world’s sheep breeds reveals high of historic mixture and strong recent selection. PLoS Biol 10:e1001258

    Article  PubMed  CAS  Google Scholar 

  13. Hayes BJ, Visscher PM, Goddard ME (2009) Increased accuracy of artificial selection by using the realized relationship matrix. Genet Res 91:47–60

    Article  CAS  Google Scholar 

  14. Van der Werf JHJ (2009) Potential benefit of genomic selection in sheep. Proc Assoc Advmt Anim Breed Genet 18:38

    Google Scholar 

Download references

Acknowledgements

The chapter is based on ideas that were developed mainly during work associated with the Australian sheep CRC data and discussion with the team and other colleagues. For this, Hans Daetwyler, Sam Clark, Andrew Swan, Nasir Moghaddar, Ben Hayes, John Henshall, Brian Kinghorn, John Hickey, and Rob Banks are acknowledged.

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media, LLC

About this protocol

Cite this protocol

van der Werf, J. (2013). Genomic Selection in Animal Breeding Programs. In: Gondro, C., van der Werf, J., Hayes, B. (eds) Genome-Wide Association Studies and Genomic Prediction. Methods in Molecular Biology, vol 1019. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-447-0_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-62703-447-0_26

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-446-3

  • Online ISBN: 978-1-62703-447-0

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Navigation