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Mouse Models of COPD

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Lung Innate Immunity and Inflammation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1809))

Abstract

Elastase and chronic cigarette smoke exposure animal models are commonly used to study lung morphologic and functional changes associated with emphysema-like airspace enlargement in various animal species. This chapter describes the rationale for using these two models to study mechanisms of COPD pathogenesis and provides protocols for their implementation. E-cigarettes are an emerging health concern and may also contribute to lung disease. Accordingly, approaches to study e-cigarette vapors are provided. This chapter also includes methods and tools necessary to assess lung morphologic and functional changes in animals with emphysema-like airspace enlargement.

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Acknowledgments

Funding sources are RO1HL077328 (IP) and 2014 Alpha-1 Foundation Gordon L. Snider Scholar Award (KAS).

Author information

Authors and Affiliations

  1. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, University of Colorado Denver, Anschutz Medical Campus, Denver, CO, USA

    Karina A. Serban & Irina Petrache

Authors
  1. Karina A. Serban
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  2. Irina Petrache
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Corresponding author

Correspondence to Karina A. Serban .

Editor information

Editors and Affiliations

  1. Department of Immunology and Microbiology University of Colorado School of Medicine, Department of Biomedical Research and Center for Genes Environment and Health, National Jewish Health Denver, CO, USA, Aurora,, Colorado, USA

    Scott Alper

  2. Division of Pulmonary Sciences and Critical Care Medicine Department of Medicine University of Colorado Denver, Division of Pulmonary, Critical Care and Sleep Medicine Department of Medicine National Jewish Health Denver, CO, USA, Aurora, Colorado, USA

    William J. Janssen

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Serban, K.A., Petrache, I. (2018). Mouse Models of COPD. In: Alper, S., Janssen, W. (eds) Lung Innate Immunity and Inflammation. Methods in Molecular Biology, vol 1809. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8570-8_25

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  • DOI: https://doi.org/10.1007/978-1-4939-8570-8_25

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8569-2

  • Online ISBN: 978-1-4939-8570-8

  • eBook Packages: Springer Protocols

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