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Neuroimmune Imbalances and Yin-Yang Dynamics in Stress, Anxiety, and Depression

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Psychoneuroimmunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1781))

Abstract

Evidences from psychoneuroimmunology (PNI) and systems biology studies support a conceptual framework of “Yin-Yang dynamics” for understanding the “whole mind-body system.” The Yin-Yang dynamical balances in the stress response networks may be critical for health and diseases, especially mental health and psychiatric disorders. Specifically, the neuroimmune imbalances have been found as the important features and potential biomarkers of stress, anxiety, depression, and systemic inflammation. At the system levels, factors such as psychosocial stress and obesity, especially a leaky gut, may result in the imbalance between regulatory and proinflammatory T cells. At the molecular and cellular levels, the imbalances in multiple networks including the cytokine and redox pathways, immune-kynurenine networks, HPA axis, and synaptic plasticity in the hypothalamus are the key factors in depression. The recognition of the neuroimmune imbalances and the restoration of the Yin-Yang dynamical balances need to become a high priority toward the development of dynamical systems medicine for psychiatric diseases including depression and schizophrenia.

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References

  1. Yan Q (2014) From pharmacogenomics and systems biology to personalized care: a framework of systems and dynamical medicine. Methods Mol Biol 1175:3–17

    Article  Google Scholar 

  2. Yan Q (2017) Toward dynamical systems medicine: personalized and preventive strategies. Pers Med 14:377–380

    Article  CAS  Google Scholar 

  3. Yan Q (2016) Psychoneuroimmunology: systems biology approaches to mind-body medicine. Springer, New York

    Book  Google Scholar 

  4. Peters EMJ, Müller Y, Snaga W et al (2017) Hair and stress: a pilot study of hair and cytokine balance alteration in healthy young women under major exam stress. PLoS One 12:e0175904

    Article  Google Scholar 

  5. Head KA, Kelly GS (2009) Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev 14:114–140

    PubMed  Google Scholar 

  6. Hou R, Garner M, Holmes C et al (2017) Peripheral inflammatory cytokines and immune balance in generalised anxiety disorder: case-controlled study. Brain Behav Immun 62:212–218

    Article  CAS  Google Scholar 

  7. Salim S, Chugh G, Asghar M (2012) Inflammation in anxiety. Adv Protein Chem Struct Biol 88:1–25

    Article  CAS  Google Scholar 

  8. Han HW, Ohn JH, Moon J, Kim JH (2013) Yin and Yang of disease genes and death genes between reciprocally scale-free biological networks. Nucleic Acids Res 41:9209–9217

    Article  CAS  Google Scholar 

  9. R K, D M A, C N, S N W, C D (2014) Oxidative imbalance and anxiety disorders. Curr Neuropharmacol 12:193–204

    Article  Google Scholar 

  10. Kara MI, Yanık S, Keskinruzgar A et al (2012) Oxidative imbalance and anxiety in patients with sleep bruxism. Oral Surg Oral Med Oral Pathol Oral Radiol 114:604–609

    Article  Google Scholar 

  11. Wood SK (2014) Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers. Front Psychol 5:950

    Article  Google Scholar 

  12. Stein MB, Paulus MP (2009) Imbalance of approach and avoidance: the Yin and Yang of anxiety disorders. Biol Psychiatry 66:1072–1074

    Article  Google Scholar 

  13. Myint AM, Schwarz MJ, Steinbusch HWM, Leonard BE (2009) Neuropsychiatric disorders related to interferon and interleukins treatment. Metab Brain Dis 24:55–68

    Article  CAS  Google Scholar 

  14. Haroon E, Raison CL, Miller AH (2012) Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37:137–162

    Article  CAS  Google Scholar 

  15. Grimm S, Beck J, Schuepbach D et al (2008) Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol Psychiatry 63:369–376

    Article  Google Scholar 

  16. Szelényi J, Vizi ES (2007) The catecholamine cytokine balance: interaction between the brain and the immune system. Ann N Y Acad Sci 1113:311–324

    Article  Google Scholar 

  17. Ge J-F, Qi C-C, Zhou J-N (2013) Imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induced depression in rats. Behav Brain Res 249:38–43

    Article  CAS  Google Scholar 

  18. Bardelli C, Amoruso A, Manzetti E et al (2013) Recurrent major depressive disorder: imbalance of neurokinin (NK)-1 and NK-2 receptor expression in monocytes. Pharmacol Res 68:24–30

    Article  CAS  Google Scholar 

  19. Neumann ID, Landgraf R (2012) Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 35:649–659

    Article  CAS  Google Scholar 

  20. Depciuch J, Sowa-Kućma M, Nowak G et al (2017) The role of zinc deficiency-induced changes in the phospholipid-protein balance of blood serum in animal depression model by Raman, FTIR and UV-Vis spectroscopy. Biomed Pharmacother 89:549–558

    Article  CAS  Google Scholar 

  21. Monteagudo PT, Falcão AA, Verreschi ITN, Zanella M-T (2016) The imbalance of sex-hormones related to depressive symptoms in obese men. Aging Male 19:20–26

    Article  CAS  Google Scholar 

  22. Won E, Kim Y-K (2016) Stress, the autonomic nervous system, and the immune-kynurenine pathway in the etiology of depression. Curr Neuropharmacol 14:665–673

    Article  CAS  Google Scholar 

  23. Christmas DM, Potokar J, Davies SJ (2011) A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase. Neuropsychiatr Dis Treat 7:431–439

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Cho HJ, Savitz J, Dantzer R et al (2017) Sleep disturbance and kynurenine metabolism in depression. J Psychosom Res 99:1–7

    Article  Google Scholar 

  25. Naoi M, Maruyama W, Shamoto-Nagai M (2018) Type a monoamine oxidase and serotonin are coordinately involved in depressive disorders: from neurotransmitter imbalance to impaired neurogenesis. J Neural Transm (Vienna) 125(1):53–66

    Article  CAS  Google Scholar 

  26. Lipina TV, Fletcher PJ, Lee FH, Wong AHC, Roder JC (2013) Disrupted-in-schizophrenia-1 Gln31Leu polymorphism results in social anhedonia associated with monoaminergic imbalance and reduction of CREB and β-arrestin-1,2 in the nucleus accumbens in a mouse model of depression. Neuropsychopharmacology 38:423–436

    Article  CAS  Google Scholar 

  27. Müller N, Schwarz MJ (2008) A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major depression as inflammatory CNS disorders. Eur Arch Psychiatry Clin Neurosci 258(Suppl 2):97–106

    Article  Google Scholar 

  28. Miüller N, Schwarz MJ (2007) The immunological basis of glutamatergic disturbance in schizophrenia: towards an integrated view. J Neural Transm Suppl:269–280

    Google Scholar 

  29. Réus GZ, de Moura AB, Silva RH et al (2017) Resilience dysregulation in major depressive disorder: focus on glutamatergic imbalance and microglial activation. Curr Neuropharmacol

    Google Scholar 

  30. Miller AH (2009) Norman cousins lecture. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. Brain Behav Immun 23:149–158

    Article  CAS  Google Scholar 

  31. Toben C, Baune BT (2015) An act of balance between adaptive and maladaptive immunity in depression: a role for T lymphocytes. J Neuroimmune Pharmacol 10:595–609

    Article  Google Scholar 

  32. Huang T-L, Lee C-T (2007) T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression. Psychiatry Clin Neurosci 61:415–420

    Article  CAS  Google Scholar 

  33. Kim Y-K, Na K-S, Myint A-M, Leonard BE (2016) The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Prog Neuro-Psychopharmacol Biol Psychiatry 64:277–284

    Article  CAS  Google Scholar 

  34. Freitas AE, Bettio LEB, Neis VB et al (2014) Agmatine abolishes restraint stress-induced depressive-like behavior and hippocampal antioxidant imbalance in mice. Prog Neuro-Psychopharmacol Biol Psychiatry 50:143–150

    Article  CAS  Google Scholar 

  35. Budni J, Zomkowski AD, Engel D et al (2013) Folic acid prevents depressive-like behavior and hippocampal antioxidant imbalance induced by restraint stress in mice. Exp Neurol 240:112–121

    Article  CAS  Google Scholar 

  36. Rivera-Rivera Y, García Y, Toro V et al (2014) Depression correlates with increased plasma levels of inflammatory cytokines and a dysregulated oxidant/antioxidant balance in HIV-1-infected subjects undergoing antiretroviral therapy. J Clin Cell Immunol 5

    Google Scholar 

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Authors and Affiliations

  1. PharmTao, Santa Clara, CA, USA

    Qing Yan

  2. University of Maryland University College, Adelphi, MD, USA

    Qing Yan

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  1. Qing Yan
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Correspondence to Qing Yan .

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  1. University of Maryland University College, Adelphi, MD, PharmTao, Santa Clara, California, USA

    Qing Yan

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Yan, Q. (2018). Neuroimmune Imbalances and Yin-Yang Dynamics in Stress, Anxiety, and Depression. In: Yan, Q. (eds) Psychoneuroimmunology. Methods in Molecular Biology, vol 1781. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7828-1_5

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  • DOI: https://doi.org/10.1007/978-1-4939-7828-1_5

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7827-4

  • Online ISBN: 978-1-4939-7828-1

  • eBook Packages: Springer Protocols

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