Abstract
The brain is one of the most critical and sensitive organs in vertebrates. It is therefore understandably well shielded from various disturbing influences, including the occurrence of potential toxins that may be present in the bloodstream. It has long been recognized that there is a selective barrier between the bloodstream and the brain tissue. This barrier, called the blood-brain barrier, allows efficient uptake of nutrients in order to meet the extensive metabolic needs of the brain, but at the same time withholds many compounds from entering brain tissue, whereas these same compounds can readily penetrate most other tissues in the body (for reviews see Pardridge, 1998). The specialized structure of the endothelial cells in the blood capillaries of the brain is largely responsible for these unique barrier properties. Recent work has provided compelling evidence that at least one active efflux drug transporter in the blood-brain barrier, P-glycoprotein (P-gp), makes an important contribution to the special barrier properties.
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Schinkel, A.H. (2001). The Roles of P-Glycoprotein and MRP1 in the Blood-Brain and Blood-Cerebrospinal Fluid Barriers. In: Dansette, P.M., et al. Biological Reactive Intermediates VI. Advances in Experimental Medicine and Biology, vol 500. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0667-6_60
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DOI: https://doi.org/10.1007/978-1-4615-0667-6_60
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