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Anxiogenic and Other Effects of mCPP, a 5-HT, 1C Agonist

  • Chapter
New Concepts in Anxiety

Abstract

A decade ago, central 5-HT receptors were classified into 5-HT1 and 5-HT2 types (Peroutka and Snyder, 1979). More recently, 5-HT3 receptors were recognized (Kilpatrick et al., 1987) and 5-HT4 sites have also been proposed (Dumuis et al., 1989). The 5-HT1 and 5-HT2 types have been divided into various subtypes on the basis of binding properties and 5-HT1 and 5-HT2 families have now been suggested by a number of groups (e.g. Schmidt and Peroutka, 1989). The 5-HT1C site, with which this chapter is mainly concerned, occurs very densely in the choroid plexus but is also widely distributed in the rest of the brain (Pazos et al., 1987). Although activation of other 5-HT1 subtype receptors stimulates cyclic AMP synthesis, activation of 5-HT1C sites stimulates phosphoinositide hydrolysis (Conn and Sanders-Bush, 1987a) which is a characteristic of 5-HT2 receptors. The 5-HT1C receptor also has both molecular biological and pharmacological similarities with 5-HT2 sites (Julius et al., 1988; Pritchett et al., 1988; Schmidt and Peroutka, 1989). Recent work suggests that its activation may have many behavioural and physiological effects and it could thus be implicated in a number of disorders of the central nervous system including anxiety.

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Authors and Affiliations

  1. Institute of Neurology, Queen Square, London, WC1N 3BG, UK

    G. Curzon

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  1. G. Curzon
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  2. E. L. Gibson
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  3. A. J. Kennedy
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  4. G. A. Kennett
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  5. G. S. Sarna
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  6. P. Whitton
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Editors and Affiliations

  1. Pierre Fabre Médicament, Castres, France

    M. Briley

  2. Psychopharmacology Research Unit, UMDS, Guy’s Hospital, London, SE1 9RT, UK

    S. E. File

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© 1991 Macmillan Publishers Limited

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Curzon, G., Gibson, E.L., Kennedy, A.J., Kennett, G.A., Sarna, G.S., Whitton, P. (1991). Anxiogenic and Other Effects of mCPP, a 5-HT, 1C Agonist. In: Briley, M., File, S.E. (eds) New Concepts in Anxiety. Palgrave, London. https://doi.org/10.1007/978-1-349-11847-2_10

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