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Long Noncoding RNAs: An Overview

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Long Non-Coding RNAs

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2372))

Abstract

Recently an explosion in the discovery of long noncoding RNAs (lncRNAs) was obtained by high-throughput sequencing. Genome-wide transcriptome analyses, in conjugation with research for epigenetic modifications of chromatins, identified a novel type of non–protein coding transcripts longer than 200 nucleotides named lncRNAs . They are gradually emerging as functional and critical participants in many physiological processes. Here we gave an overview of the characteristics, biological functions, and working mechanism for this new class of noncoding RNA molecules.

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Acknowledgments

This work was supported, in whole or in part, by The National Key Research and Development Program of China 2017YFA0105501 (X. Z.), The National Natural Science Foundation of China 81302262 (X. Z.), and The Science and Technology Project of Guangdong Province 2015A020212019 (X. Z.). We apologize to scientists whose work was not discussed here due to space constraints.

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Authors and Affiliations

  1. State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

    Dongmei Zhang

  2. Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Center for Stem Cell Biology and Tissue Engineering, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People’s Republic of China

    Mengshi Wu, Minmin **ong, Peng **ang & **aomin Zhong

  3. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People’s Republic of China

    Congjian Xu

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  1. Dongmei Zhang
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  2. Mengshi Wu
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  3. Minmin **ong
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  4. Congjian Xu
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  5. Peng **ang
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  6. **aomin Zhong
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Correspondence to **aomin Zhong .

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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA

    Lin Zhang

  2. Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA

    **aowen Hu

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Zhang, D., Wu, M., **ong, M., Xu, C., **ang, P., Zhong, X. (2021). Long Noncoding RNAs: An Overview. In: Zhang, L., Hu, X. (eds) Long Non-Coding RNAs. Methods in Molecular Biology, vol 2372. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1697-0_23

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  • DOI: https://doi.org/10.1007/978-1-0716-1697-0_23

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1696-3

  • Online ISBN: 978-1-0716-1697-0

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