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Integrated Bioprocessing for Plant Cell Cultures

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Plant Cells

Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 72))

Abstract

Plant cell suspension culture has become the focus of much attention as a tool for the production of secondary metabolites including paclitaxel, a well-known anticancer agent. Recently, it has also been regarded as one of the host systems for the production of recombinant proteins. In order to produce phytochemicals using plant cell cultures, efficient processes must be developed with adequate bioreactor design. Most of the plant secondary metabolites are toxic to cells at the high concentrations required during culture. Therefore, if the product could be removed in situ during culture, productivity might be enhanced due to the alleviation of this toxicity. In situ removal or extractive bioconversion of such products can be performed by in situ extraction with various kinds of organic solvents. In situ adsorption using polymeric resins is another possibility. Using the fact that secondary metabolites are generally hydrophobic, various integrated bioprocessing techniques can be designed not only to lower toxicity, but also to enhance productivity. In this article, in situ extraction, in situ adsorption, utilization of cyclodextrins, and the application of aqueous two-phase systems in plant cell cultures are reviewed.

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Sogang University, C.P.O. Box 1142, Seoul, 100-611, Korea

    Jeong-Woo Choi

  2. Department of Chemical Engineering, Kangwon National University, Chunchon, 200-701, Korea

    Gyu Heon Cho

  3. Department of Chemical Engineering and Technology, Ajou University, Suwon, 442-749, Korea

    Sang Yo Byun

  4. Department of Biological Engineering and Center of Advanced Bioseparation Technology, Inha University, Inchon, 402-751, Korea

    Dong-Il Kim

Authors
  1. Jeong-Woo Choi
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  2. Gyu Heon Cho
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  3. Sang Yo Byun
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  4. Dong-Il Kim
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Editor information

Editors and Affiliations

  1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China

    J. -J. Zhong

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© 2001 Springer-Verlag Berlin Heidelberg

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Choi, JW., Cho, G.H., Byun, S.Y., Kim, DI. (2001). Integrated Bioprocessing for Plant Cell Cultures. In: Zhong, J.J., et al. Plant Cells. Advances in Biochemical Engineering/Biotechnology, vol 72. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45302-4_3

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  • DOI: https://doi.org/10.1007/3-540-45302-4_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41849-8

  • Online ISBN: 978-3-540-45302-4

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