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Collection
Onco-proteogenomics
- Submission status
- Open
- Open for submission from
- 01 September 2022
- Submission deadline
- Ongoing
With the advancement of sequencing technologies, whole genome sequence information can be obtained robustly in a fairly short time and at low cost. Yet, currently there is often a lack of connection of genomic data to proteomic data, probably due to the fact that standard proteomics workflows rely on databases of only known wild-type/canonical proteins, but these databases generally do not integrate the data of cancer-associated proteins with countless amino acid sequence alterations due to gene mutations, post-translational modifications, and aberrant chromosome rearrangement. Therefore, in the next phase, it becomes extremely important to integrate experimentally-generated Mass Spectrometric data accordingly with the genomic information to identify tumor-specific proteins and isoforms.
Onco-proteogenomics has great promise and holds the key in improving our understanding of cancer biology and it is anticipated that the routine utilization of this integrated omics approach would become one of the gold standards of precision oncology. In this collection, we welcome original articles focusing on cancer proteogenomics research.
Articles (33 in this collection)
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Antiproliferative effect of indeno[1,2-d]thiazolo[3,2-a]pyrimidine analogues on IL-6 mediated STAT3 and role of the apoptotic pathway in albino Wistar rats of ethyl carbamate-induced lung carcinoma: In-silico, In-vitro, and In-vivo study
Authors (first, second and last of 16)
- Archana Bharti Sonkar
- Abhishek Verma
- Sudipta Saha
- Content type: Research
- Open Access
- Published: 26 June 2024
- Cancer Cell International
- Article: 219
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The sensitivity of acute myeloid leukemia cells to cytarabine is increased by suppressing the expression of Heme oxygenase-1 and hypoxia-inducible factor 1-alpha
Authors (first, second and last of 14)
- Mohammad Sadeghi
- Asma Moslehi
- Farhad Jadidi-Niaragh
- Content type: Research
- Open Access
- Published: 25 June 2024
- Cancer Cell International
- Article: 217
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Syntaxin6 contributes to hepatocellular carcinoma tumorigenesis via enhancing STAT3 phosphorylation
Authors (first, second and last of 13)
- Li Huang
- **aoting Zhong
- Jianming Ye
- Content type: Research
- Open Access
- Published: 04 June 2024
- Cancer Cell International
- Article: 197
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Long non-coding RNA PXN-AS1 promotes glutamine synthetase-mediated chronic myeloid leukemia BCR::ABL1-independent resistance to Imatinib via cell cycle signaling pathway
Authors (first, second and last of 10)
- Yifei Li
- Shiyi Yuan
- Shifeng Lou
- Content type: Research
- Open Access
- Published: 29 May 2024
- Cancer Cell International
- Article: 186
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EZH2 G553C significantly increases the risk of brain metastasis from lung cancer due to salt bridge instability
Authors (first, second and last of 5)
- Hanjun Wang
- Ling Wang
- Feng Gao
- Content type: Research
- Open Access
- Published: 19 May 2024
- Cancer Cell International
- Article: 175
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New insights into targeted therapy of glioblastoma using smart nanoparticles
Authors (first, second and last of 6)
- Habib Ghaznavi
- Reza Afzalipour
- Roghayeh Sheervalilou
- Content type: Review
- Open Access
- Published: 07 May 2024
- Cancer Cell International
- Article: 160
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RBP7 functions as a tumor suppressor in HR + breast cancer by inhibiting the AKT/SREBP1 pathway and reducing fatty acid
Authors (first, second and last of 11)
- Yue Yu
- Zhihua Xu
- Yan Chen
- Content type: Research
- Open Access
- Published: 29 March 2024
- Cancer Cell International
- Article: 118
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The upregulation of VGF enhances the progression of oral squamous carcinoma
Authors (first, second and last of 6)
- Chung-Hsien Chou
- Chun-Han Yen
- Kuo-Wei Chang
- Content type: Research
- Open Access
- Published: 25 March 2024
- Cancer Cell International
- Article: 115
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Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
Authors (first, second and last of 7)
- Joseba Elizazu
- Aizpea Artetxe-Zurutuza
- Estefania Carrasco-Garcia
- Content type: Research
- Open Access
- Published: 13 March 2024
- Cellular Oncology
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Mitochondrial respiratory chain component NDUFA4: a promising therapeutic target for gastrointestinal cancer
Authors (first, second and last of 7)
- Quanling Zhou
- **aohui Li
- Ya Zhou
- Content type: Review
- Open Access
- Published: 05 March 2024
- Cancer Cell International
- Article: 97
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STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
Authors (first, second and last of 10)
- Ziying Zhao
- Yuan Chu
- Meidong Xu
- Content type: Research
- Open Access
- Published: 04 March 2024
- Cellular Oncology
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RhoB expression associated with chemotherapy response and prognosis in colorectal cancer
Authors (first, second and last of 11)
- Maria Kopsida
- Na Liu
- **ao-Feng Sun
- Content type: Research
- Open Access
- Published: 15 February 2024
- Cancer Cell International
- Article: 75
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Omics-based molecular classifications empowering in precision oncology
Authors (first, second and last of 11)
- Zhaokai Zhou
- Ting Lin
- Zaoqu Liu
- Content type: Review
- Published: 31 January 2024
- Cellular Oncology
- Pages: 759 - 777
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EN1 promotes lung metastasis of salivary adenoid cystic carcinoma by regulating the PI3K-AKT pathway and epithelial-mesenchymal transition
Authors (first, second and last of 6)
- Yajuan Cui
- Ye Zhang
- Chuan-**ang Zhou
- Content type: Research
- Open Access
- Published: 30 January 2024
- Cancer Cell International
- Article: 51
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Identification of a new gene signature for prognostic evaluation in cervical cancer: based on cuproptosis-associated angiogenesis and multi-omics analysis
Authors (first, second and last of 6)
- Jiawen Kang
- **gwen Jiang
- Lesai Li
- Content type: Research
- Open Access
- Published: 10 January 2024
- Cancer Cell International
- Article: 23
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Identification of TNFRSF21 as an inhibitory factor of osteosarcoma based on a necroptosis-related prognostic gene signature and molecular experiments
Authors (first, second and last of 6)
- **ang Li
- Zhenqian Sun
- Guangjun Jiao
- Content type: Research
- Open Access
- Published: 06 January 2024
- Cancer Cell International
- Article: 14
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Clinical applications and perspectives of circulating tumor DNA in gastric cancer
Authors (first, second and last of 4)
- **g-Han Li
- Dan-Ying Zhang
- Ling Dong
- Content type: Review
- Open Access
- Published: 06 January 2024
- Cancer Cell International
- Article: 13
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RORα inhibits gastric cancer proliferation through attenuating G6PD and PFKFB3 induced glycolytic activity
Authors (first, second and last of 8)
- **aoshan Wang
- Junyi Zhang
- Zhengguang Wang
- Content type: Research
- Open Access
- Published: 06 January 2024
- Cancer Cell International
- Article: 12
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A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma
Authors (first, second and last of 8)
- Congya Li
- Linchao Ding
- Junlan Zhu
- Content type: Research
- Open Access
- Published: 21 December 2023
- Cancer Cell International
- Article: 334
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miR-590-5p/Tiam1-mediated glucose metabolism promotes malignant evolution of pancreatic cancer by regulating SLC2A3 stability
Authors (first, second and last of 7)
- Ying Liu
- Aihua **
- Zhenhua Lin
- Content type: Research
- Open Access
- Published: 28 November 2023
- Cancer Cell International
- Article: 301
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Circular RNAs in renal cell carcinoma: from mechanistic to clinical perspective
Authors (first, second and last of 6)
- Chunjie Huang
- Pooya Esfani Sarafraz
- Majid Nazari
- Content type: Review
- Open Access
- Published: 22 November 2023
- Cancer Cell International
- Article: 288
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CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
Authors (first, second and last of 6)
- Guanya Li
- Kai **ao
- Tingting Li
- Content type: Research
- Published: 20 November 2023
- Cellular Oncology
- Pages: 851 - 865
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Leveraging a disulfidptosis/ferroptosis-based signature to predict the prognosis of lung adenocarcinoma
Authors (first, second and last of 8)
- **aoqing Ma
- Zilin Deng
- ** Chang
- Content type: Research
- Open Access
- Published: 09 November 2023
- Cancer Cell International
- Article: 267
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Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis
Authors (first, second and last of 15)
- Nathália Cristina Campanella
- Izabela Natalia Faria Gomes
- Rui Manuel Reis
- Content type: Research
- Open Access
- Published: 31 October 2023
- Cancer Cell International
- Article: 256
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Whole exome sequencing identifies novel variants of PIK3CA and validation of hotspot mutation by droplet digital PCR in breast cancer among Indian population
Authors (first, second and last of 16)
- Rahul Kumar
- Rakesh Kumar
- Pranay Tanwar
- Content type: Research
- Open Access
- Published: 11 October 2023
- Cancer Cell International
- Article: 236
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FOXA1/MND1/TKT axis regulates gastric cancer progression and oxaliplatin sensitivity via PI3K/AKT signaling pathway
Authors (first, second and last of 10)
- **aosi Hu
- Shuai Zhou
- Aman Xu
- Content type: Research
- Open Access
- Published: 10 October 2023
- Cancer Cell International
- Article: 234
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DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress
Authors (first, second and last of 11)
- Xu Lin
- Ye-han Liu
- Jian Hu
- Content type: Research
- Open Access
- Published: 23 September 2023
- Cancer Cell International
- Article: 208
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Enhancing prognostic accuracy in head and neck squamous cell carcinoma chemotherapy via a lipid metabolism-related clustered polygenic model
Authors (first, second and last of 14)
- **angwan Miao
- Hao Wang
- Mingliang **ang
- Content type: Research
- Open Access
- Published: 11 August 2023
- Cancer Cell International
- Article: 164
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Decoding the prognostic significance of integrator complex subunit 9 (INTS9) in glioma: links to TP53 mutations, E2F signaling, and inflammatory microenvironments
Authors (first, second and last of 5)
- Yu-Chieh Lin
- Pei-Chi Chang
- Yao-Feng Li
- Content type: Research
- Open Access
- Published: 03 August 2023
- Cancer Cell International
- Article: 154
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miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
Authors (first, second and last of 7)
- Wenjian Cen
- Qin Yan
- Neng Jiang
- Content type: Research
- Published: 27 July 2023
- Cellular Oncology
- Pages: 1821 - 1835
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FUT8 is regulated by miR‐122‐5p and promotes malignancies in intrahepatic cholangiocarcinoma via PI3K/AKT signaling
Authors (first, second and last of 8)
- Fanghua Chen
- Yin Li
- Shu Zhang
- Content type: Original article
- Published: 08 November 2022
- Cellular Oncology
- Pages: 79 - 91
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Lymphocyte antigen 6G6D-mediated modulation through p38α MAPK and DNA methylation in colorectal cancer
Authors (first, second and last of 9)
- Francesca Pia Caruso
- Mario Rosario D’Andrea
- Massimo Pancione
- Content type: Research
- Open Access
- Published: 11 August 2022
- Cancer Cell International
- Article: 253