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Application of Gas Chromatography and Gas Chromatography–Mass Spectrometry in Quality Control of Chinese Medicines

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Quality Control of Chinese Medicines

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Abstract

Gas chromatography (GC) is a well-known and widely employed technique for separation and analysis of the gaseous and volatile components. Modern GC technique was firstly invented by James and Martin in 1952 and applied for the separation of amino acids. After decades of development, GC has large number of applications in a variety of fields due to its high efficiency and great sensitivity, especially for the research of Chinese herbal medicine including the determination and characterization of bioactive compounds such as volatile oils, fingerprint analysis of holistic quality control, pharmacokinetics research and metabolomics analysis. In addition, GC and GC-MS have also been adopted and are now used for an increasingly growing list of applications in other various fields, such as environmental analysis, food and beverage analysis and so on.

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Abbreviations

CHMs:

Chinese herbal medicines

UPLC-DAD:

Ultrahigh-performance liquid chromatography-diode array detector

UPLC-MS:

Ultrahigh-performance liquid chromatography-mass spectrometry

GC-MS:

Gas chromatography-mass spectrometry

EI:

Electron impact; PCA, principal components analysis

GC × GC:

Comprehensive 2D gas chromatography

SIM:

Selective ion monitoring

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  1. Jiliang Cao and Maoyuan Jiang: These authors contributed equally to this work.

Authors and Affiliations

  1. College of Pharmacy, Shenzhen Technology University, Shenzhen, 518118, China

    Jiliang Cao

  2. Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao, 999078, China

    Maoyuan Jiang, Shiyao Hua, Lele Yang & Peng Li

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  1. Jiliang Cao
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  5. Peng Li
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Correspondence to Peng Li .

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  1. State Key Laboratory of Quality Research in Chinese Medicine and Macao Centre for Testing of Chinese Medicine, University of Macau, Macau, China

    Shao** Li

  2. State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau, China

    **g Zhao

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Cao, J., Jiang, M., Hua, S., Yang, L., Li, P. (2024). Application of Gas Chromatography and Gas Chromatography–Mass Spectrometry in Quality Control of Chinese Medicines. In: Li, S., Zhao, J. (eds) Quality Control of Chinese Medicines . Springer, Singapore. https://doi.org/10.1007/978-981-99-9871-5_14

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