Dominant Mutations

Although most mutations are predicted to result in a loss of function, it is possible that the mutation will result in the addition of a new and essential function. In these circumstances, the mutation results in the creation of a new allele with a new function. Any heterozygote with the latest and original wild-type alleles will express the new allele. This will classify the mutation as dominant genetically. This type of mutation is known as a gain-of-function mutation. This type of mutation can result in the formation of a new protein isoform. This novel isoform may serve an essential new function. Notably, GOF mutations produce proteins with new activities, which bring variety to the biological system.