Dimethylphosphate

Dimethyl phosphate (DMP) is a marker for exposure to an insecticide, organophosphate. A metabolite of phosphamidon, mevinphos, dicrotophos, monocrotophos, dichlorvos, and trichlorfon is dimethyl phosphate (DMP). High DMP levels have been linked to pervasive developmental problems, memory loss, and attention-deficit disorders. Additionally, it has been related to aggression, sadness, and suicide and may have contributed to the development of Gulf War syndrome. Reduced plasma cholinesterase or pseudocholinesterase activity can be used to gauge toxicity at high levels. Atropine and/or pralidoxime are used as treatments for acute poisoning. According to WHO, dichlorvos insecticide is hydrolyzed to dichloroethanol, dichloroacetaldehyde, dichloroacetic acid, and dimethyl phosphate. Dichlorvos detoxification occurs in the liver, but other organs such as blood, kidneys, and spleen convert dichlorvos into dimethyl phosphate. In several studies, it was found that patient exposed to...