Abstract
Ayurveda is an ancient Indian system of medicine that has been used for thousands of years. In recent years, there has been growing interest in using Ayurvedic principles and natural products to discover new drugs. Reverse pharmacology, an approach that involves using traditional knowledge to guide drug discovery, has been gaining attention in this field. In this chapter, an overview of Ayurvedic principles and the concept of reverse pharmacology in drug discovery is provided. Some of the drugs developed through this approach are discussed here as case studies. While there are challenges and limitations to this approach, deriving novel therapeutic applications from the existing formulation and develo** safer drugs from natural sources represent crucial benefits.
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Aggarwal BB, Prasad S, Reuter S, Kannappan R, Yadav VR, Park B, Hye Kim J, Gupta SC, Phromnoi K, Sundaram C, Prasad S (2011) Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: “reverse pharmacology” and “bedside to bench” approach. Curr Drug Targets 12:1595–1653
Ahn K (2017) The worldwide trend of using botanical drugs and strategies for develo** global drugs. BMB Rep 50:111
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807–818
Arya D, Bhatt D, Kumar R, Tewari LM, Kishor K, Joshi GC (2013) Studies on natural resources, trade and conservation of Kutki (Picrorhiza kurroa Royle ex Benth., Scrophulariaceae) from Kumaun Himalaya. Sci Res Essays 8:575–580
Balachandran P, Govindarajan R (2007) Ayurvedic drug discovery. Expert Opin Drug Discovery 2:1631–1652
Belapurkar P, Goyal P, Tiwari-Barua P (2014) Immunomodulatory effects of triphala and its individual constituents: a review. Indian J Pharm Sci 76:467
Biniaz V (2013) A review of the world-wide researches on the therapeutic effects of ginger during the past two years. Jentashapir J Health Res 4:333–337
Birkmayer W, Hornykiewicz O (1998) The effect of l-3, 4-dihydroxyphenylalanine (= DOPA) on akinesia in parkinsonism. Parkinsonism Relat Disord 4:59–60
Bodeker G, Rasoanaivo P, Willcox M, Warrell D (2004) Traditional medicinal plants and malaria. CRC Press
Bucar F, Wube A, Schmid M (2013) Natural product isolation—how to get from biological material to pure compounds. Nat Prod Rep 30:525–545
Chander R, Dwivedi Y, Rastogi R, Sharma SK, Garg NK, Kapoor NK, Dhawan BN (1990) Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei. Indian J Med Res 92:34–37
Chandran U, Mehendale N, Tillu G, Patwardhan B (2015) Network pharmacology of ayurveda formulation Triphala with special reference to anti-cancer property. Comb Chem High Throughput Screen 18:846–854
Chawla A, Kumar A, Warghat A, Singh S, Bhushan S, Sharma RK, Bhattacharya A, Kumar S (2020) Approaches for conservation and improvement of Himalayan plant genetic resources. In: Advancement in crop improvement techniques. Woodhead Publishing, pp 297–317
Cordell GA (2011) Sustainable medicines and global health care. Planta Med 77:1129–1138
Cragg GM, Schepartz SA, Suffness M, Grever MR (1993) The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents. J Nat Prod 56:1657–1668
Damodaran M, Ramaswamy R (1937) Isolation of l-3: 4-dihydroxyphenylalanine from the seeds of Mucuna pruriens. Biochem J 31:2149
Dasgupta T, Banerjee S, Yadava PK, Rao AR (2004) Chemopreventive potential of Azadirachta indica (Neem) leaf extract in murine carcinogenesis model systems. J Ethnopharmacol 92:23–36
David B, Wolfender JL, Dias DA (2015) The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev 14:299–315
Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, Manyam BV (2009) Centella asiatica extract selectively decreases amyloid β levels in hippocampus of Alzheimer’s disease animal model. Phytother Res 23:14–19
Dhuley JN (1999) Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals. J Ethnopharmacol 67:361–365
Dubey NK, Kumar R, Tripathi P (2004) Global promotion of herbal medicine: India’s opportunity. Curr Sci 86:37–41
Gangal N, Nagle V, Pawar Y, Dasgupta S (2020) Reconsidering traditional medicinal plants to combat COVID-19. AIJR Preprints 34:1–6
Garodia P, Ichikawa H, Malani N, Sethi G, Aggarwal BB (2007) From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc Integr Oncol 5:25–37
Gill M, Kinra M, Rai A, Chamallamudi MR, Kumar N (2018) Evaluation of antidepressant activity of methanolic extract of Saraca asoca bark in a chronic unpredictable mild stress model. Neuroreport 29:134–140
Govindarajan R, Vijayakumar M, Pushpangadan P (2005) Antioxidant approach to disease management and the role of ‘Rasayana’ herbs of Ayurveda. J Ethnopharmacol 99:165–178
Haider M, Dholakia D, Panwar A, Garg P, Anand V, Gheware A, Singhal K, Singh D, Burse SA, Enayathullah MG, Parekh Y (2021) Traditional use of Cissampelos pareira L. for hormone disorder and fever provides molecular links of ESR1 modulation to viral inhibition. BioRxiv 2021-02
Hasan SZ, Vedant M, Swati S, Garvita A, Sunita S, Sarika S (2009) Current status of herbal drugs and their future perspectives. In: Biological forum, vol 1. Satya Prakashan, pp 12–17
Hassannia B, Logie E, Vandenabeele P, Berghe TV, Berghe WV (2020) Withaferin A: from ayurvedic folk medicine to preclinical anti-cancer drug. Biochem Pharmacol 173:113602
Jafari S, Abdollahi M, Saeidnia S (2014) Personalized medicine: a confluence of traditional and contemporary medicine. Altern Ther Health Med 20:31–40
Jain H, Arora N, Arora P, Nama N (2022) Isoniazid and rifampicin induced hepatoprotective activity of root and leaves extract of Picrorhiza Kurroa. J Pharm Negat Results 4833–4837
Juneja K, Mishra R, Chauhan S, Gupta S, Roy P, Sircar D (2020) Metabolite profiling and wound-healing activity of Boerhavia diffusa leaf extracts using in vitro and in vivo models. J Tradit Complement Med 10:52–59
Kharb A, Chauhan RS (2021) Complexity of gene paralogues resolved in biosynthetic pathway of hepatoprotective iridoid glycosides in a medicinal herb, Picrorhiza kurroa through differential NGS transcriptomes. Mol Gen Genomics 296:863–876
Kinghorn AD, Su BN, Jang DS, Chang LC, Lee D, Gu JQ, Carcache-Blanco EJ, Pawlus AD, Lee SK, Park EJ, Cuendet M (2004) Natural inhibitors of carcinogenesis. Planta Med 70:691–705
Kumar S, Sharma S, Vasudeva N (2013) Screening of antidiabetic and antihyperlipidemic potential of oil from Piper longum and piperine with their possible mechanism. Expert Opin Pharmacother 14:1723–1736
Kumar S, Dobos GJ, Rampp T (2017) The significance of ayurvedic medicinal plants. J Evid Based Complementary Altern Med 22:494–501
Lancet JAMA (2003) Herbal remedies and the bias against Ayurveda. Curr Sci 84:1165–1166
Lee JA, Uhlik MT, Moxham CM, Tomandl D, Sall DJ (2012) Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. J Med Chem 55:4527–4538
Manik RK, Jain D, Joshi A (2023) Effect of naturopathy and Ayurveda on cystic fibrosis: detailed review analysis. J Surv Fish Sci 10:4214–4230
Manyam BV, Dhanasekaran M, Hare TA (2004) Neuroprotective effects of the antiparkinson drug Mucuna pruriens. Phytother Res 18:706–712
Meena AK, Bansal P, Kumar S (2009) Plants-herbal wealth as a potential source of ayurvedic drugs. Asian J Tradit Med 4:152–170
Mehta S, Sharma AK, Singh RK (2021) Advances in ethnobotany, synthetic phytochemistry and pharmacology of endangered herb Picrorhiza kurroa (Kutki): a comprehensive review (2010-2020). Mini Rev Med Chem 21:2976–2995
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–477
Panda V, Deshmukh A, Singh S, Shah T, Hingorani L (2021) An Ayurvedic formulation of Emblica officinalis and Curcuma longa alleviates insulin resistance in diabetic rats: involvement of curcuminoids and polyphenolics. J Ayurveda Integr Med 12:506–513
Pande VN (1979) Effect of indigenous drugs in the management of certain liver disorder. Banaras Hindu University, Varanasi
Pandey BL, Das PK (1988) Immunopharmacological studies on Picrorhiza kurroa Royle-ex Benth. Part III: adrenergic mechanisms of anti-inflammatory action. Indian J Physiol Pharmacol 32:120–125
Pandey VN, Day M (1966) Clinical and experimental studies on certain liver diseases with special references to indigenous drug Kutaki (Picrorhiza kurroa) in the treatment of jaundice (Kamala Roga). Doctoral dissertation, Ph.D. thesis, Banaras Hindu University, Varanasi
Pandey MM, Rastogi S, Rawat AKS (2013) Indian traditional ayurvedic system of medicine and nutritional supplementation. Evid Based Complement Alternat Med 2013:376327
Parasuraman S, Thing GS, Dhanaraj SA (2014) Polyherbal formulation: concept of ayurveda. Pharmacogn Rev 8:73
Parveen A, Babbar R, Agarwal S, Kotwani A, Fahim M (2011) Mechanistic clues in the cardioprotective effect of Terminalia arjuna bark extract in isoproterenol-induced chronic heart failure in rats. Cardiovasc Toxicol 11:48–57
Parveen A, Babbar R, Agarwal S, Kotwani A, Fahim M (2012) Terminalia arjuna enhances baroreflex sensitivity and myocardial function in isoproterenol-induced chronic heart failure rats. J Cardiovasc Pharmacol Ther 17:199–207
Patel MG, Pundarikakshudu K (2016) Anti-arthritic activity of a classical Ayurvedic formulation Vatari Guggulu in rats. J Tradit Complement Med 6:389–394
Pathak-Gandhi N, Vaidya AD (2017) Management of Parkinson’s disease in Ayurveda: medicinal plants and adjuvant measures. J Ethnopharmacol 197:46–51
Patwardhan B (2000) Ayurveda: the designer medicine. Indian Drugs 37:213–227
Patwardhan B, Mashelkar RA (2009) Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? Drug Discov Today 14:804–811
Paul S, Chakraborty S, Anand U, Dey S, Nandy S, Ghorai M, Saha SC, Patil MT, Kandimalla R, Proćków J, Dey A (2021) Withania somnifera (L.) Dunal (Ashwagandha): a comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects. Biomed Pharmacother 143:112175
Peterson CT, Denniston K, Chopra D (2017) Therapeutic uses of triphala in ayurvedic medicine. J Altern Complement Med 23:607–614
Phillips S, Ruggier R, Hutchinson SE (1993) Zingiber officinale (ginger)—an antiemetic for day case surgery. Anaesthesia 48:715–717
Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag AE, Lang AE (2017) Parkinson disease. Nat Rev Dis Primers 3:1–21
Rai R, Singh HK, Prasad S (2015) A special extract of Bacopa monnieri (CDRI-08) restores learning and memory by upregulating expression of the NMDA receptor subunit GluN2B in the brain of scopolamine-induced amnesic mice. Evid Based Complement Alternat Med 2015:254303
Ramalingaswami V, Satyavati GV (1982) Sir Ram Nath Chopra. Indian J Med Res 76:5–6
Rao S, Kini V, Hegde SK, Meera S, Rao P, George T, Baliga MS (2023) Ayurvedic drug triphala in combination with providone iodine mitigates radiation-induced mucositis in head and neck cancer patients without affecting the tumor response. Indian J Otolaryngol Head Neck Surg 75:1–10
Reddy KRC (2017) Remedial merits of Piper longum Linn with astonishing antidiabetic potential. Int J Green Pharm 11
Sairam KCHV, Rao CV, Babu MD, Kumar KV, Agrawal VK, Goel RK (2002) Antiulcerogenic effect of methanolic extract of Emblica officinalis: an experimental study. J Ethnopharmacol 82:1–9
Sakuljaitrong S, Buddhakala N, Chomko S, Talubmook C (2013) Effects of flower extract from lotus (Nelumbo nucifera) on hypoglycemic and hypolipidemic in streptozotocin-induced diabetic rats. Int J Sci Eng Res 4:1441–1446
Satyavati GV (1988) Gum guggul (Commiphora mukul)—the success story of an ancient insight leading to a modern discovery. Indian J Med Res 87:327–335
Saxena S, Pant N, Jain DC, Bhakuni RS (2003) Antimalarial agents from plant sources. Curr Sci 1314–1329
Sen G (1931) Rauwolfia serpentina, a new Indian drug for insanity and high blood pressure. Ind Med World 2:194–201
Shah BN (2009) Textbook of pharmacognosy and phytochemistry. Elsevier India
Shakya AK (2016) Medicinal plants: future source of new drugs. Int J Herb Med 4:59–64
Sharma RK, Dash B (1983) Charaka samhita. Choukhambha Sanskrit Series Office, Varanasi
Sharma T, Jana S (2020) Boswellic acids as natural anticancer medicine: precious gift to humankind. J Herb Med 20:100313
Sharma B, Balomajumder C, Roy P (2008) Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem Toxicol 46:2376–2383
Sharma R, Martins N, Kuca K, Chaudhary A, Kabra A, Rao MM, Prajapati PK (2019) Chyawanprash: a traditional Indian bioactive health supplement. Biomolecules 9:161
Shashikumara S, Purushotham K, Darshan CL, Kalal BS (2022) Characterization of antidepressant activity of Saraca asoca flower (Roxb.) Wilde in mice subjected to acute restraint stress. Am J Transl Res 14:5014
Singh S, Krishna TA, Kamalraj S, Kuriakose GC, Valayil JM, Jayabaskaran C (2015) Phytomedicinal importance of Saraca asoca (Ashoka): an exciting past, an emerging present and a promising future. Curr Sci 109:1790–1801
Singh R, Goel S, Bourgeade P, Aleya L, Tewari D (2021) Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19. Environ Sci Pollut Res 28:1–27
Singhal B, Lalkaka J, Sankhla C (2003) Epidemiology and treatment of Parkinson’s disease in India. Parkinsonism Relat Disord 9:105–109
Surh YJ (2011) Reverse pharmacology applicable for botanical drug development–inspiration from the legacy of traditional wisdom. J Tradit Complement Med 1:5
Swami DV, Anitha M, Rao MCS, Sharangi AB (2022) Medicinal plants: perspectives and retrospectives. In: Medicinal plants. pp 1–28
Takenaka T (2001) Classical vs reverse pharmacology in drug discovery. BJU Int 88:7–10
Thakur K, Partap M, Kumar D, Warghat AR (2019) Enhancement of picrosides content in Picrorhiza kurroa Royle ex Benth. mediated through nutrient feeding approach under aeroponic and hydroponic system. Ind Crop Prod 133:160–167
Thomson M, Corbin R, Leung L (2014) Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis. J Am Board Fam Med 27:115–122
Tinello F, Zannoni S, Lante A (2020) Antioxidant properties of soybean oil supplemented with ginger and turmeric powders. Appl Sci 10:8438
Tripathi SC, Patnaik GK, Dhawan BN (1991) Hepatoprotective activity of picroliv against alcohol-carbon tetra chloride induced damage in rat. Indian J Pharmacol 23:143
Ueda H, Ippoushi K, Takeuchi A (2010) Repeated oral administration of a squeezed ginger (Zingiber officinale) extract augmented the serum corticosterone level and had anti-inflammatory properties. Biosci Biotechnol Biochem 74:2248–2252
Upadhyay AK, Kumar K, Kumar A, Mishra HS (2010) Tinospora cordifolia (Willd.) Hook. f. and Thoms.(Guduchi)–validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res 1:112
Vaidya AD (2006) Reverse pharmacological correlates of ayurvedic drug actions. Indian J Pharmacol 38:311
Vaidya AD, Devasagayam TP (2007) Current status of herbal drugs in India: an overview. J Clin Biochem Nutr 41:1–11
Vaidya R, Aloorkar S, Sheth A, Pandya S (1978a) Activity of bromoergocryptine, Mucuna pruriens and L-dopa in the control of hyperprolactinaemia. Neurol India 26:179–182
Vaidya R, Sheth A, Aloorkar S, Rege N, Bagadia V, Devi P, Shah L (1978b) The inhibitory effect of the cowhage plant-Mucuna pruriens-and L-dopa on chlorpromazine-induced hyperprolactinaemia in man. Neurol India 26:177–178
Variya BC, Bakrania AK, Patel SS (2020) Antidiabetic potential of gallic acid from Emblica officinalis: improved glucose transporters and insulin sensitivity through PPAR-γ and Akt signaling. Phytomedicine 73:152906
Vasala PA (2012) Ginger. In: Handbook of herbs and spices. Woodhead Publishing, pp 319–335
Vikrant V, Grover JK, Tandon N, Rathi SS, Gupta N (2001) Treatment with extracts of Momordica charantia and Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats. J Ethnopharmacol 76:139–143
Vines G (2004) Herbal harvests with a future: towards sustainable sources for medicinal plants. Plantlife International
Wang MW, Hao X, Chen K (2007) Biological screening of natural products and drug innovation in China. Philos Trans R Soc Lond B Biol Sci 362:1093–1105
Wei X, Luo C, He Y, Huang H, Ran F, Liao W, Tan P, Fan S, Cheng Y, Zhang D, Lin J (2021) Hepatoprotective effects of different extracts from Triphala against CCl4-induced acute liver injury in mice. Front Pharmacol 12:664607
Willcox ML, Graz B, Falquet J, Diakite C, Giani S, Diallo D (2011) A “reverse pharmacology” approach for develo** an anti-malarial phytomedicine. Malar J 10:1–10
Willcox M, Siegfried N, Johnson Q (2012) Capacity for clinical research on herbal medicines in Africa. J Altern Complement Med 18:622–628
Xu J, Liu T, Li Y, Yuan C, Ma H, Seeram NP, Liu F, Mu Y, Huang X, Li L (2018) Hypoglycemic and hypolipidemic effects of triterpenoid-enriched Jamun (Eugenia jambolana Lam.) fruit extract in streptozotocin-induced type 1 diabetic mice. Food Funct 9:3330–3337
Yu G, **ang W, Zhang T, Zeng L, Yang K, Li J (2020) Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther 20:1–16
Zidorn C (2017) Guidelines for consistent characterisation and documentation of plant source materials for studies in phytochemistry and phytopharmacology. Phytochemistry 139:56–59
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Sidhic, J., Athira, C.K., Narayanankutty, A., George, S. (2024). Ayurveda-Inspired Reverse Pharmacology in Drug Discovery. In: Haridas, M., Abdulhameed, S., Francis, D., Kumar, S.S. (eds) Drugs from Nature: Targets, Assay Systems and Leads. Springer, Singapore. https://doi.org/10.1007/978-981-99-9183-9_5
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