Abstract
Hydrogels are a type of biomaterial that are made up of water and a polymer network. They are often used in tissue engineering because they offer numerous advantages, including tunable mechanical properties and higher water content. Synthetic polymers play a vital role in the development of hydrogels for tissue engineering. Synthetic polymers such as poly(glycolic acid) (PGA), poly(lactic-co-glycolic acid) (PLGA), and poly(lactic acid) (PLA) are commonly used to make hydrogel scaffolds that can deliver drug or bioactive factors to promote cell growth, differentiation, and angiogenesis. By incorporating bioactive factors into synthetic polymer matrices, controlled release can be achieved to regulate these cellular processes. Overall, synthetic polymers offer a broad range of potential applications in tissue engineering. The ability to design and engineer synthetic polymers with desired characteristics has paved the way for advancements in tissue regeneration, wound healing, organ transplantation, and drug delivery systems. However, challenges such as in vivo biocompatibility, immunogenicity, and long-term stability of synthetic polymers need to be addressed to fully harness their potential in tissue engineering applications.
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References
Abandansari HS, Aghaghafari E, Nabid MR, Niknejad H (2013) Preparation of injectable and thermoresponsive hydrogel based on penta-block copolymer with improved sol stability and mechanical properties. Polymer 54:1329–1340. https://doi.org/10.1016/j.polymer.2013.01.004
Abid S, Hussain T, Raza ZA, Nazir A (2019) Current applications of electrospun polymeric nanofibers in cancer therapy. Mater Sci Eng C 97:966–977. https://doi.org/10.1016/j.msec.2018.12.105
Abou-Okeil A, Aly AA, Amr A, Soliman AAF (2019) Biocompatible hydrogel for cartilage repair with adjustable properties. Polym Adv Technol 30:2026–2033. https://doi.org/10.1002/pat.4635
Advincula RC, Dizon JRC, Caldona EB, Viers RA, Siacor FDC, Maalihan RD, Espera AH (2021) On the progress of 3D-printed hydrogels for tissue engineering. MRS Commun 11:539–553. https://doi.org/10.1557/s43579-021-00069-1
Agarwal S, Saha S, Balla VK, Pal A, Barui A, Bodhak S (2020) Current developments in 3D bioprinting for tissue and organ regeneration—a review. Front Mech Eng 6:589171. https://doi.org/10.3389/fmech.2020.589171
Ajmal G, Bonde GV, Mittal P, Khan G, Pandey VK, Bakade BV, Mishra B (2019) Biomimetic PCL-gelatin based nanofibers loaded with ciprofloxacin hydrochloride and quercetin: a potential antibacterial and anti-oxidant dressing material for accelerated healing of a full thickness wound. Int J Pharm 567:118480. https://doi.org/10.1016/j.ijpharm.2019.118480
Akiyama Y, Okano T (2015) Temperature-responsive polymers for cell culture and tissue engineering applications. In: Switchable and responsive surfaces and materials for biomedical applications. Elsevier, pp 203–233. https://doi.org/10.1016/B978-0-85709-713-2.00009-2
Aldakheel F, Mohsen D, El Sayed M, Alawam K, Binshaya A, Alduraywish S (2023) Silver nanoparticles loaded on chitosan-g-PVA hydrogel for the wound-healing applications. Molecules 28:3241. https://doi.org/10.3390/molecules28073241
Ali M, Brocchini S (2006) Synthetic approaches to uniform polymers. Adv Drug Deliv Rev 58:1671–1687. https://doi.org/10.1016/j.addr.2006.10.002
Almawash S, Osman SK, Mustafa G, El Hamd MA (2022) Current and future prospective of injectable hydrogels—design challenges and limitations. Pharmaceuticals 15:371. https://doi.org/10.3390/ph15030371
Almeida HV, Eswaramoorthy R, Cunniffe GM, Buckley CT, O’Brien FJ, Kelly DJ (2016) Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration. Acta Biomater 36:55–62. https://doi.org/10.1016/j.actbio.2016.03.008
Andrzejowski P, Giannoudis PV (2019) The ‘diamond concept’ for long bone non-union management. J Orthop Traumatol 20:21. https://doi.org/10.1186/s10195-019-0528-0
Annabi N, Tsang K, Mithieux SM, Nikkhah M, Ameri A, Khademhosseini A, Weiss AS (2013) Highly elastic micropatterned hydrogel for engineering functional cardiac tissue. Adv Funct Mater 23:4950–4959. https://doi.org/10.1002/adfm.201300570
Ansar R, Saqib S, Mukhtar A, Niazi MBK, Shahid M, Jahan Z, Kakar SJ, Uzair B, Mubashir M, Ullah S, Khoo KS, Lim HR, Show PL (2022) Challenges and recent trends with the development of hydrogel fiber for biomedical applications. Chemosphere 287:131956. https://doi.org/10.1016/j.chemosphere.2021.131956
Antunes FE, Gentile L, Oliviero Rossi C, Tavano L, Ranieri GA (2011) Gels of Pluronic F127 and nonionic surfactants from rheological characterization to controlled drug permeation. Colloids Surf B Biointerfaces 87:42–48. https://doi.org/10.1016/j.colsurfb.2011.04.033
Bahram M, Mohseni N, Moghtader M (2016) An introduction to hydrogels and some recent applications. In: Majee SB (ed) Emerging concepts in analysis and applications of hydrogels. INTECH. https://doi.org/10.5772/64301
Bai X, Gao M, Syed S, Zhuang J, Xu X, Zhang X-Q (2018) Bioactive hydrogels for bone regeneration. Bioact Mater 3:401–417. https://doi.org/10.1016/j.bioactmat.2018.05.006
Barrett-Catton E, Ross ML, Asuri P (2021) Multifunctional hydrogel nanocomposites for biomedical applications. Polymers 13:856. https://doi.org/10.3390/polym13060856
Bashir S, Hina M, Iqbal J, Rajpar AH, Mujtaba MA, Alghamdi NA, Wageh S, Ramesh K, Ramesh S (2020) Fundamental concepts of hydrogels: synthesis, properties, and their applications. Polymers 12:2702. https://doi.org/10.3390/polym12112702
Bates NM, Puy C, Jurney PL, McCarty OJT, Hinds MT (2020) Evaluation of the effect of crosslinking method of poly(vinyl alcohol) hydrogels on thrombogenicity. Cardiovasc Eng Technol 11:448–455. https://doi.org/10.1007/s13239-020-00474-y
Beamish JA, Zhu J, Kottke-Marchant K, Marchant RE (2009) The effects of monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol) diacrylate hydrogels used for tissue engineering. J Biomed Mater Res A 92(2):441–450. https://doi.org/10.1002/jbm.a.32353
Bedian L, Villalba-Rodríguez AM, Hernández-Vargas G, Parra-Saldivar R, Iqbal HMN (2017) Bio-based materials with novel characteristics for tissue engineering applications—a review. Int J Biol Macromol 98:837–846. https://doi.org/10.1016/j.ijbiomac.2017.02.048
Bejaoui M, Galai H, Touati F, Kouass S (2023) Multifunctional roles of PVP as a versatile biomaterial in solid state. In: Ahmad U (ed) Dosage forms—innovation and future perspectives. IntechOpen. https://doi.org/10.5772/intechopen.99431
Blache U, Ehrbar M (2018) Inspired by nature: hydrogels as versatile tools for vascular engineering. Adv Wound Care 7:232–246. https://doi.org/10.1089/wound.2017.0760
Blatchley MR, Gerecht S (2015) Acellular implantable and injectable hydrogels for vascular regeneration. Biomed Mater 10:034001. https://doi.org/10.1088/1748-6041/10/3/034001
Bordbar S, Lotfi Bakhshaiesh N, Khanmohammadi M, Sayahpour FA, Alini M, Baghaban Eslaminejad M (2020) Production and evaluation of decellularized extracellular matrix hydrogel for cartilage regeneration derived from knee cartilage. J Biomed Mater Res A 108:938–946. https://doi.org/10.1002/jbm.a.36871
Burnham MR, Turner JN, Szarowski D, Martin DL (2006) Biological functionalization and surface micropatterning of polyacrylamide hydrogels. Biomaterials 27:5883–5891. https://doi.org/10.1016/j.biomaterials.2006.08.001
Cai Z, Wan Y, Becker ML, Long Y-Z, Dean D (2019) Poly(propylene fumarate)—based materials: synthesis, functionalization, properties, device fabrication and biomedical applications. Biomaterials 208:45–71. https://doi.org/10.1016/j.biomaterials.2019.03.038
Caló E, Khutoryanskiy VV (2015) Biomedical applications of hydrogels: a review of patents and commercial products. Eur Polym J 65:252–267. https://doi.org/10.1016/j.eurpolymj.2014.11.024
Cao-Luu N-H, Pham Q-T, Yao Z-H, Wang F-M, Chern C-S (2019) Synthesis and characterization of poly(N-isopropylacrylamide-co-acrylamide) mesoglobule core–silica shell nanoparticles. J Colloid Interface Sci 536:536–547. https://doi.org/10.1016/j.jcis.2018.10.091
Chang SH, Lee HJ, Park S, Kim Y, Jeong B (2018) Fast degradable polycaprolactone for drug delivery. Biomacromolecules 19:2302–2307. https://doi.org/10.1021/acs.biomac.8b00266
Chaudhary S, Chakraborty E (2022) Hydrogel based tissue engineering and its future applications in personalized disease modeling and regenerative therapy. Beni-Suef Univ J Basic Appl Sci 11:3. https://doi.org/10.1186/s43088-021-00172-1
Chavda H, Patel C (2011) Effect of crosslinker concentration on characteristics of superporous hydrogel. Int J Pharm Investig 1:17. https://doi.org/10.4103/2230-973X.76724
Chen W, Tao W (2022) Precise control of the structure of synthetic hydrogel networks for precision medicine applications. Matter 5:18–19. https://doi.org/10.1016/j.matt.2021.12.007
Christen M-O, Vercesi F (2020) Polycaprolactone: how a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics. Clin Cosmet Investig Dermatol 13:31–48. https://doi.org/10.2147/CCID.S229054
Clark D, Nakamura M, Miclau T, Marcucio R (2017) Effects of aging on fracture healing. Curr Osteoporos Rep 15:601–608. https://doi.org/10.1007/s11914-017-0413-9
Cooke JP, Meng S (2020) Vascular regeneration in peripheral artery disease. Arterioscler Thromb Vasc Biol 40:1627–1634. https://doi.org/10.1161/ATVBAHA.120.312862
Correa S, Grosskopf AK, Lopez Hernandez H, Chan D, Yu AC, Stapleton LM, Appel EA (2021) Translational applications of hydrogels. Chem Rev 121:11385–11457. https://doi.org/10.1021/acs.chemrev.0c01177
Curley JL, Moore MJ (2011) Facile micropatterning of dual hydrogel systems for 3D models of neurite outgrowth. J Biomed Mater Res A 99A:532–543. https://doi.org/10.1002/jbm.a.33195
D’Arcangelo E, McGuigan AP (2015) Micropatterning strategies to engineer controlled cell and tissue architecture in vitro. BioTechniques 58:13–23. https://doi.org/10.2144/000114245
Dethe MR, Prabakaran A, Ahmed H, Agrawal M, Roy U, Alexander A (2022) PCL-PEG copolymer based injectable thermosensitive hydrogels. J Control Rel 343:217–236. https://doi.org/10.1016/j.jconrel.2022.01.035
Díaz-García D, Filipová A, Garza-Veloz I, Martinez-Fierro ML (2021) A beginner’s introduction to skin stem cells and wound healing. Int J Mol Sci 22:11030. https://doi.org/10.3390/ijms222011030
Dwivedi R, Kumar S, Pandey R, Mahajan A, Nandana D, Katti DS, Mehrotra D (2020) Polycaprolactone as biomaterial for bone scaffolds: review of literature. J Oral Biol Craniofacial Res 10:381–388. https://doi.org/10.1016/j.jobcr.2019.10.003
Eming SA, Martin P, Tomic-Canic M (2014) Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med 6(265):265sr6. https://doi.org/10.1126/scitranslmed.3009337
Evans ND, Oreffo ROC, Healy E, Thurner PJ, Man YH (2013) Epithelial mechanobiology, skin wound healing, and the stem cell niche. J Mech Behav Biomed Mater 28:397–409. https://doi.org/10.1016/j.jmbbm.2013.04.023
Feng X, Wang G, Neumann K, Yao W, Ding L, Li S, Sheng Y, Jiang Y, Bradley M, Zhang R (2017) Synthesis and characterization of biodegradable poly(ether-ester) urethane acrylates for controlled drug release. Mater Sci Eng C 74:270–278. https://doi.org/10.1016/j.msec.2016.12.009
Feng B, Ji T, Wang X, Fu W, Ye L, Zhang H, Li F (2020) Engineering cartilage tissue based on cartilage-derived extracellular matrix cECM/PCL hybrid nanofibrous scaffold. Mater Des 193:108773. https://doi.org/10.1016/j.matdes.2020.108773
Frey BM, Zeisberger SM, Hoerstrup SP (2016) Tissue engineering and regenerative medicine—new initiatives for individual treatment offers. Transfus Med Hemother 43:318–320. https://doi.org/10.1159/000450716
Frost BA, Sutliff BP, Thayer P, Bortner MJ, Foster EJ (2019) Gradient poly(ethylene glycol) diacrylate and cellulose nanocrystals tissue engineering composite scaffolds via extrusion bioprinting. Front Bioeng Biotechnol 7:280. https://doi.org/10.3389/fbioe.2019.00280
Gaaz T, Sulong A, Akhtar M, Kadhum A, Mohamad A, Al-Amiery A (2015) Properties and applications of polyvinyl alcohol, halloysite nanotubes and their nanocomposites. Molecules 20:22833–22847. https://doi.org/10.3390/molecules201219884
Gaidai AR, Vakuliuk PV, Demianenko EM, Kozakevych RB, Murlanova TV, Furtat IM, Lobanov VV, Tertykh VA, Golub AA (2022) Interaction of ornidazole with initial and functionalized silicas. Appl Surf Sci 580:152218. https://doi.org/10.1016/j.apsusc.2021.152218
Gao Y, Ren F, Ding B, Sun N, Liu X, Ding X, Gao S (2011) A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel. J Drug Target 19:516–527. https://doi.org/10.3109/1061186X.2010.519031
Gentile P, Chiono V, Carmagnola I, Hatton P (2014) An overview of poly(lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering. Int J Mol Sci 15:3640–3659. https://doi.org/10.3390/ijms15033640
Ghasemiyeh P, Mohammadi-Samani S (2021) Polymers blending as release modulating tool in drug delivery. Front Mater 8:752813. https://doi.org/10.3389/fmats.2021.752813
Ghitman J, Biru EI, Stan R, Iovu H (2020) Review of hybrid PLGA nanoparticles: future of smart drug delivery and theranostics medicine. Mater Des 193:108805. https://doi.org/10.1016/j.matdes.2020.108805
Gögele C, Müller S, Belov S, Pradel A, Wiltzsch S, Lenhart A, Hornfeck M, Kerling V, Rübling A, Kühl H, Schäfer-Eckart K, Minnich B, Weiger TM, Schulze-Tanzil G (2022) Biodegradable poly(D-L-lactide-co-glycolide) (PLGA)-infiltrated bioactive glass (CAR12N) scaffolds maintain mesenchymal stem cell chondrogenesis for cartilage tissue engineering. Cell 11:1577. https://doi.org/10.3390/cells11091577
Gopinathan J, Noh I (2018) Click chemistry-based injectable hydrogels and bioprinting inks for tissue engineering applications. Tissue Eng Regen Med 15:531–546. https://doi.org/10.1007/s13770-018-0152-8
Guan G, Yu C, **ng M, Wu Y, Hu X, Wang H, Wang L (2019) Hydrogel small-diameter vascular graft reinforced with a braided fiber strut with improved mechanical properties. Polymers 11:810. https://doi.org/10.3390/polym11050810
Ha M, Athirasala A, Tahayeri A, Menezes PP, Bertassoni LE (2020) Micropatterned hydrogels and cell alignment enhance the odontogenic potential of stem cells from apical papilla in-vitro. Dent Mater 36:88–96. https://doi.org/10.1016/j.dental.2019.10.013
Hamlekhan A, Moztarzadeh F, Mozafari M, Azami M, Nezafati N (2011) Preparation of laminated poly(ε-caprolactone)-gelatin-hydroxyapatite nanocomposite scaffold bioengineered via compound techniques for bone substitution. Biomatter 1:91–101. https://doi.org/10.4161/biom.1.1.17445
Han F, Wang J, Ding L, Hu Y, Li W, Yuan Z, Guo Q, Zhu C, Yu L, Wang H, Zhao Z, Jia L, Li J, Yu Y, Zhang W, Chu G, Chen S, Li B (2020) Tissue engineering and regenerative medicine: achievements, future, and sustainability in Asia. Front Bioeng Biotechnol 8:83. https://doi.org/10.3389/fbioe.2020.00083
Hao R, Cui Z, Zhang X, Tian M, Zhang L, Rao F, Xue J (2022) Rational design and preparation of functional hydrogels for skin wound healing. Front Chem 9:839055. https://doi.org/10.3389/fchem.2021.839055
Hasanzadeh E, Seifalian A, Mellati A, Saremi J, Asadpour S, Enderami SE, Nekounam H, Mahmoodi N (2023) Injectable hydrogels in central nervous system: unique and novel platforms for promoting extracellular matrix remodeling and tissue engineering. Mater Today Bio 20:100614. https://doi.org/10.1016/j.mtbio.2023.100614
He W, Ma Y, Gao X, Wang X, Dai X, Song J (2020) Application of poly(N-isopropylacrylamide) as thermosensitive smart materials. J Phys Conf Ser 1676:012063. https://doi.org/10.1088/1742-6596/1676/1/012063
Hennink WE, Van Nostrum CF (2012) Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 64:223–236. https://doi.org/10.1016/j.addr.2012.09.009
Hernandez I, Kumar A, Joddar B (2017) A bioactive hydrogel and 3D printed polycaprolactone system for bone tissue engineering. Gels 3:26. https://doi.org/10.3390/gels3030026
Hosseini M, Shafiee A (2021) Engineering bioactive scaffolds for skin regeneration. Small 17:2101384. https://doi.org/10.1002/smll.202101384
Hu K, Zhou N, Li Y, Ma S, Guo Z, Cao M, Zhang Q, Sun J, Zhang T, Gu N (2016) Sliced magnetic polyacrylamide hydrogel with cell-adhesive microarray interface: a novel multicellular spheroid culturing platform. ACS Appl Mater Interfaces 8:15113–15119. https://doi.org/10.1021/acsami.6b04112
Jeon O, Lee K, Alsberg E (2018) Spatial micropatterning of growth factors in 3D hydrogels for location-specific regulation of cellular behaviors. Small 14:1800579. https://doi.org/10.1002/smll.201800579
** Y, Koh RH, Kim S-H, Kim KM, Park GK, Hwang NS (2020) Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair. Mater Sci Eng C 115:111096. https://doi.org/10.1016/j.msec.2020.111096
Joo Y-S, Cha J-R, Gong M-S (2018) Biodegradable shape-memory polymers using polycaprolactone and isosorbide based polyurethane blends. Mater Sci Eng C 91:426–435. https://doi.org/10.1016/j.msec.2018.05.063
Joshi A, Choudhury S, Gugulothu SB, Visweswariah SS, Chatterjee K (2022) Strategies to promote vascularization in 3D printed tissue scaffolds: trends and challenges. Biomacromolecules 23:2730–2751. https://doi.org/10.1021/acs.biomac.2c00423
Kharaziha M, Baidya A, Annabi N (2021) Rational design of immunomodulatory hydrogels for chronic wound healing. Adv Mater 33:2100176. https://doi.org/10.1002/adma.202100176
Killion JA, Geever LM, Devine DM, Kennedy JE, Higginbotham CL (2011) Mechanical properties and thermal behaviour of PEGDMA hydrogels for potential bone regeneration application. J Mech Behav Biomed Mater 4:1219–1227. https://doi.org/10.1016/j.jmbbm.2011.04.004
Kim SJ, Shin SR, Lee JH, Lee SH, Kim SI (2003) Electrical response characterization of chitosan/polyacrylonitrile hydrogel in NaCl solutions. J Appl Polym Sci 90:91–96. https://doi.org/10.1002/app.12541
Koczkur KM, Mourdikoudis S, Polavarapu L, Skrabalak SE (2015) Polyvinylpyrrolidone (PVP) in nanoparticle synthesis. Dalton Trans 44:17883–17905. https://doi.org/10.1039/C5DT02964C
Kurakula M, Rao GSNK (2020) Pharmaceutical assessment of polyvinylpyrrolidone (PVP): as excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition. J Drug Deliv Sci Technol 60:102046. https://doi.org/10.1016/j.jddst.2020.102046
Le PN, Huynh CK, Tran NQ (2018) Advances in thermosensitive polymer-grafted platforms for biomedical applications. Mater Sci Eng C 92:1016–1030. https://doi.org/10.1016/j.msec.2018.02.006
Leeper NJ, Hunter AL, Cooke JP (2010) Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells. Circulation 122:517–526. https://doi.org/10.1161/CIRCULATIONAHA.109.881441
Li J, Kao WJ (2003) Synthesis of polyethylene glycol (PEG) derivatives and pegylated−peptide biopolymer conjugates. Biomacromolecules 4:1055–1067. https://doi.org/10.1021/bm034069l
Li J, Mooney DJ (2016) Designing hydrogels for controlled drug delivery. Nat Rev Mater 1:16071. https://doi.org/10.1038/natrevmats.2016.71
Li X, **ong Y (2022) Application of “Click” chemistry in biomedical hydrogels. ACS Omega 7:36918–36928. https://doi.org/10.1021/acsomega.2c03931
Li G, Li S, Zhang L, Chen S, Sun Z, Li S, Zhang L, Yang Y (2019) Construction of biofunctionalized anisotropic hydrogel micropatterns and their effect on Schwann cell behavior in peripheral nerve regeneration. ACS Appl Mater Interfaces 11:37397–37410. https://doi.org/10.1021/acsami.9b08510
Li J, Wu C, Chu PK, Gelinsky M (2020) 3D printing of hydrogels: rational design strategies and emerging biomedical applications. Mater Sci Eng R Rep 140:100543. https://doi.org/10.1016/j.mser.2020.100543
Li Y, Wang J, Wang Y, Cui W (2021) Advanced electrospun hydrogel fibers for wound healing. Compos Part B Eng 223:109101. https://doi.org/10.1016/j.compositesb.2021.109101
Liao X, Yang X, Deng H, Hao Y, Mao L, Zhang R, Liao W, Yuan M (2020) Injectable hydrogel-based nanocomposites for cardiovascular diseases. Front Bioeng Biotechnol 8:251. https://doi.org/10.3389/fbioe.2020.00251
Lim YW, Tan WS, Ho KL, Mariatulqabtiah AR, Abu Kasim NH, Abd Rahman N, Wong TW, Chee CF (2022) Challenges and complications of poly(lactic-co-glycolic acid)-based long-acting drug product development. Pharmaceutics 14:614. https://doi.org/10.3390/pharmaceutics14030614
Liu N, Pan J, Miao Y-E, Liu T, Xu F, Sun H (2014) Electrospinning of poly (ε-caprolactone-co-lactide)/pluronic blended scaffolds for skin tissue engineering. J Mater Sci 49:7253–7262. https://doi.org/10.1007/s10853-014-8432-8
Liu J, Zheng H, Poh P, Machens H-G, Schilling A (2015) Hydrogels for engineering of perfusable vascular networks. Int J Mol Sci 16:15997–16016. https://doi.org/10.3390/ijms160715997
Liu G, Ding Z, Yuan Q, **e H, Gu Z (2018) Multi-layered hydrogels for biomedical applications. Front Chem 6:439. https://doi.org/10.3389/fchem.2018.00439
Liu S, Jiang T, Guo R, Li C, Lu C, Yang G, Nie J, Wang F, Yang X, Chen Z (2021) Injectable and degradable PEG hydrogel with antibacterial performance for promoting wound healing. ACS Appl Bio Mater 4:2769–2780. https://doi.org/10.1021/acsabm.1c00004
Liu Z, **n W, Ji J, Xu J, Zheng L, Qu X, Yue B (2022) 3D-Printed hydrogels in orthopedics: developments, limitations, and perspectives. Front Bioeng Biotechnol 10:845342. https://doi.org/10.3389/fbioe.2022.845342
Liu J, Yang L, Liu K, Gao F (2023) Hydrogel scaffolds in bone regeneration: their promising roles in angiogenesis. Front Pharmacol 14:1050954. https://doi.org/10.3389/fphar.2023.1050954
López-Gutierrez J, Ramos-Payán R, Ayala-Ham A, Romero-Quintana JG, Castillo-Ureta H, Villegas-Mercado C, Bermúdez M, Sanchez-Schmitz G, Aguilar-Medina M (2023) Biofunctionalization of hydrogel-based scaffolds for vascular tissue regeneration. Front Mater 10:1168616. https://doi.org/10.3389/fmats.2023.1168616
Madduma-Bandarage USK, Madihally SV (2021) Synthetic hydrogels: Synthesis, novel trends, and applications. J Appl Polym Sci 138:50376. https://doi.org/10.1002/app.50376
Makadia HK, Siegel SJ (2011) Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 3:1377–1397. https://doi.org/10.3390/polym3031377
Mani MP, Sadia M, Jaganathan SK, Khudzari AZ, Supriyanto E, Saidin S, Ramakrishna S, Ismail AF, Faudzi AAM (2022) A review on 3D printing in tissue engineering applications. J Polym Eng 42:243–265. https://doi.org/10.1515/polyeng-2021-0059
Mantha S, Pillai S, Khayambashi P, Upadhyay A, Zhang Y, Tao O, Pham HM, Tran SD (2019) Smart hydrogels in tissue engineering and regenerative medicine. Materials 12:3323. https://doi.org/10.3390/ma12203323
Mueller R-J (2006) Biological degradation of synthetic polyesters—enzymes as potential catalysts for polyester recycling. Process Biochem 41:2124–2128. https://doi.org/10.1016/j.procbio.2006.05.018
Nilforoushzadeh MA, Sisakht MM, Amirkhani MA, Seifalian AM, Banafshe HR, Verdi J, Nouradini M (2020) Engineered skin graft with stromal vascular fraction cells encapsulated in fibrin–collagen hydrogel: a clinical study for diabetic wound healing. J Tissue Eng Regen Med 14:424–440. https://doi.org/10.1002/term.3003
Nöth U, Rackwitz L, Heymer A, Weber M, Baumann B, Steinert A, Schütze N, Jakob F, Eulert J (2007) Chondrogenic differentiation of human mesenchymal stem cells in collagen type I hydrogels. J Biomed Mater Res A 83A:626–635. https://doi.org/10.1002/jbm.a.31254
Oh M, Yoon Y, Lee TS (2020) Synthesis of poly(N -isopropylacrylamide) polymer crosslinked with an AIE-active azonaphthol for thermoreversible fluorescence. RSC Adv 10:39277–39283. https://doi.org/10.1039/D0RA08257K
Pal A, Vernon BL, Nikkhah M (2018) Therapeutic neovascularization promoted by injectable hydrogels. Bioact Mater 3:389–400. https://doi.org/10.1016/j.bioactmat.2018.05.002
Parhi R (2017) Cross-linked hydrogel for pharmaceutical applications: a review. Adv Pharm Bull 7:515–530. https://doi.org/10.15171/apb.2017.064
Pasierb A, Jezierska M, Karpuk A, Czuwara J, Rudnicka L (2022) 3D skin bioprinting: future potential for skin regeneration. Adv Dermatol Allergol 39:845–851. https://doi.org/10.5114/ada.2021.109692
Patterson CW, Stark M, Sharma S, Mundinger GS (2019) Regeneration and expansion of autologous full-thickness skin through a self-propagating autologous skin graft technology. Clin Case Rep 7:2449–2455. https://doi.org/10.1002/ccr3.2533
Pazarçeviren E, Erdemli Ö, Keskin D, Tezcaner A (2017) Clinoptilolite/PCL–PEG–PCL composite scaffolds for bone tissue engineering applications. J Biomater Appl 31:1148–1168. https://doi.org/10.1177/0885328216680152
Peixoto LS, Silva FM, Niemeyer MAL, Espinosa G, Melo PA, Nele M, Pinto JC (2006) Synthesis of poly(vinyl alcohol) and/or poly(vinyl acetate) particles with spherical morphology and core-shell structure and its use in vascular embolization. Macromol Symp 243:190–199. https://doi.org/10.1002/masy.200651118
Peng L, Zhou Y, Lu W, Zhu W, Li Y, Chen K, Zhang G, Xu J, Deng Z, Wang D (2019) Characterization of a novel polyvinyl alcohol/chitosan porous hydrogel combined with bone marrow mesenchymal stem cells and its application in articular cartilage repair. BMC Musculoskelet Disord 20:257. https://doi.org/10.1186/s12891-019-2644-7
Peters JT, Wechsler ME, Peppas NA (2021) Advanced biomedical hydrogels: molecular architecture and its impact on medical applications. Regen Biomater 8:rbab060. https://doi.org/10.1093/rb/rbab060
Rabanel J-M, Faivre J, Tehrani SF, Lalloz A, Hildgen P, Banquy X (2015) Effect of the polymer architecture on the structural and biophysical properties of PEG–PLA nanoparticles. ACS Appl Mater Interfaces 7:10374–10385. https://doi.org/10.1021/acsami.5b01423
Rahman CV, Kuhn G, White LJ, Kirby GTS, Varghese OP, McLaren JS, Cox HC, Rose FRAJ, Müller R, Hilborn J, Shakesheff KM (2013) PLGA/PEG-hydrogel composite scaffolds with controllable mechanical properties. J Biomed Mater Res B Appl Biomater 101B:648–655. https://doi.org/10.1002/jbm.b.32867
Rai R, Tallawi M, Grigore A, Boccaccini AR (2012) Synthesis, properties and biomedical applications of poly(glycerol sebacate) (PGS): a review. Prog Polym Sci 37:1051–1078. https://doi.org/10.1016/j.progpolymsci.2012.02.001
Rao SH, Harini B, Shadamarshan RPK, Balagangadharan K, Selvamurugan N (2018) Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering. Int J Biol Macromol 110:88–96. https://doi.org/10.1016/j.ijbiomac.2017.09.029
Rebers L, Reichsöllner R, Regett S, Tovar GEM, Borchers K, Baudis S, Southan A (2021) Differentiation of physical and chemical cross-linking in gelatin methacryloyl hydrogels. Sci Rep 11:3256. https://doi.org/10.1038/s41598-021-82393-z
Rusen L, Dinca V, Mustaciosu C, Icriverzi M, Sima LE, Bonciu A, Brajnicov S, Mihailescu N, Dumitrescu N, Popovici AI, Roseanu A, Dinescu M (2017) Smart thermoresponsive surfaces based on pNIPAm coatings and laser method for biological applications. In: Nikitenkov NN (ed) Modern technologies for creating the thin-film systems and coatings. INTECH. https://doi.org/10.5772/66280
Samadian H, Farzamfar S, Vaez A, Ehterami A, Bit A, Alam M, Goodarzi A, Darya G, Salehi M (2020) A tailored polylactic acid/polycaprolactone biodegradable and bioactive 3D porous scaffold containing gelatin nanofibers and Taurine for bone regeneration. Sci Rep 10:13366. https://doi.org/10.1038/s41598-020-70155-2
Sanzari I, Buratti E, Huang R, Tusan CG, Dinelli F, Evans ND, Prodromakis T, Bertoldo M (2020) Poly(N-isopropylacrylamide) based thin microgel films for use in cell culture applications. Sci Rep 10:6126. https://doi.org/10.1038/s41598-020-63228-9
Stiles PL (2010) Direct deposition of micro- and nanoscale hydrogels using Dip Pen Nanolithography (DPN). Nat Methods 7:i–ii. https://doi.org/10.1038/nmeth.f.309
Subramani K (2010) Fabrication of hydrogel micropatterns by soft photolithography. In: Emerging Nanotechnologies for Manufacturing. Elsevier, pp 261–276. https://doi.org/10.1016/B978-0-8155-1583-8.00011-9
Sultan S, Mathew AP (2018) 3D printed scaffolds with gradient porosity based on a cellulose nanocrystal hydrogel. Nanoscale 10:4421–4431. https://doi.org/10.1039/C7NR08966J
Sun S, Cui Y, Yuan B, Dou M, Wang G, Xu H, Wang J, Yin W, Wu D, Peng C (2023) Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration. Front Bioeng Biotechnol 11:1117647. https://doi.org/10.3389/fbioe.2023.1117647
Sunaryono S, Taufiq ATA, Mufti NMN, Hidayat NHN, Rugmai SRS, Soontaranon SSS, Putra EGR, Darminto D (2017) Analysis of distribution of polyvinyl alcohol hydrogel nanocrystalline by using SAXS synchrotron. IOP Conf Ser Mater Sci Eng 202:012041. https://doi.org/10.1088/1757-899X/202/1/012041
Takeo M, Lee W, Ito M (2015) Wound healing and skin regeneration. Cold Spring Harb Perspect Med 5:a023267–a023267. https://doi.org/10.1101/cshperspect.a023267
Tang G, Zhou B, Li F, Wang W, Liu Y, Wang X, Liu C, Ye X (2020) Advances of naturally derived and synthetic hydrogels for intervertebral disk regeneration. Front Bioeng Biotechnol 8:745. https://doi.org/10.3389/fbioe.2020.00745
Tartarini D, Mele E (2016) Adult stem cell therapies for wound healing: biomaterials and computational models. Front Bioeng Biotechnol 3:206. https://doi.org/10.3389/fbioe.2015.00206
Tayler IM, Stowers RS (2021) Engineering hydrogels for personalized disease modeling and regenerative medicine. Acta Biomater 132:4–22. https://doi.org/10.1016/j.actbio.2021.04.020
Tian H, Tang Z, Zhuang X, Chen X, **g X (2012) Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 37:237–280. https://doi.org/10.1016/j.progpolymsci.2011.06.004
Tiku ML, Sabaawy HE (2015) Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention. Ther Adv Musculoskelet Dis 7:76–87. https://doi.org/10.1177/1759720X15576866
Uppuluri VNVA, Thukani Sathanantham S, Bhimavarapu SK, Elumalai L (2022) Polymeric hydrogel scaffolds: skin tissue engineering and regeneration. Adv Pharm Bull 12:437–448. https://doi.org/10.34172/apb.2022.069
Varshosaz J, Hassanzadeh F, Sadeghi-aliabadi H, Larian Z, Rostami M (2014) Synthesis of Pluronic® F127-poly (methyl vinyl ether-alt-maleic acid) copolymer and production of its micelles for doxorubicin delivery in breast cancer. Chem Eng J 240:133–146. https://doi.org/10.1016/j.cej.2013.11.086
Volpi M, Paradiso A, Costantini M, Świȩszkowski W (2022) Hydrogel-based fiber biofabrication techniques for skeletal muscle tissue engineering. ACS Biomater Sci Eng 8:379–405. https://doi.org/10.1021/acsbiomaterials.1c01145
Wan J (2012) Microfluidic-based synthesis of hydrogel particles for cell microencapsulation and cell-based drug delivery. Polymers 4:1084–1108. https://doi.org/10.3390/polym4021084
Wang Y, Zhang W, Gong C, Liu B, Li Y, Wang L, Su Z, Wei G (2020) Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels. Soft Matter 16:10029–10045. https://doi.org/10.1039/D0SM00966K
Wang M, Bai J, Shao K, Tang W, Zhao X, Lin D, Huang S, Chen C, Ding Z, Ye J (2021) Poly(vinyl alcohol) hydrogels: the old and new functional materials. Int J Polym Sci 2021:1–16. https://doi.org/10.1155/2021/2225426
Wang Y, Kankala RK, Ou C, Chen A, Yang Z (2022) Advances in hydrogel-based vascularized tissues for tissue repair and drug screening. Bioact Mater 9:198–220. https://doi.org/10.1016/j.bioactmat.2021.07.005
Wechsler ME, Stephenson RE, Murphy AC, Oldenkamp HF, Singh A, Peppas NA (2019) Engineered microscale hydrogels for drug delivery, cell therapy, and sequencing. Biomed Microdevices 21:31. https://doi.org/10.1007/s10544-019-0358-0
Wei W, Ma Y, Yao X, Zhou W, Wang X, Li C, Lin J, He Q, Leptihn S, Ouyang H (2021) Advanced hydrogels for the repair of cartilage defects and regeneration. Bioact Mater 6:998–1011. https://doi.org/10.1016/j.bioactmat.2020.09.030
Wu J, Chen Q, Deng C, Xu B, Zhang Z, Yang Y, Lu T (2020) Exquisite design of injectable hydrogels in cartilage repair. Theranostics 10:9843–9864. https://doi.org/10.7150/thno.46450
**e Z, Gao M, Lobo AO, Webster TJ (2020) 3D Bioprinting in tissue engineering for medical applications: the classic and the hybrid. Polymers 12:1717. https://doi.org/10.3390/polym12081717
**ng F, Zhou C, Hui D, Du C, Wu L, Wang L, Wang W, Pu X, Gu L, Liu L, **ang Z, Zhang X (2020) Hyaluronic acid as a bioactive component for bone tissue regeneration: fabrication, modification, properties, and biological functions. Nanotechnol Rev 9:1059–1079. https://doi.org/10.1515/ntrev-2020-0084
**ong XY, Tam KC, Gan LH (2003) Synthesis and aggregation behavior of pluronic F127/poly(lactic acid) block copolymers in aqueous solutions. Macromolecules 36:9979–9985. https://doi.org/10.1021/ma035292d
Xu S, Deng L, Zhang J, Yin L, Dong A (2016) Composites of electrospun-fibers and hydrogels: a potential solution to current challenges in biological and biomedical field: composites of electrospun-fibers and hydrogels. J Biomed Mater Res B Appl Biomater 104:640–656. https://doi.org/10.1002/jbm.b.33420
Yang C, Han B, Cao C, Yang D, Qu X, Wang X (2018) An injectable double-network hydrogel for the co-culture of vascular endothelial cells and bone marrow mesenchymal stem cells for simultaneously enhancing vascularization and osteogenesis. J Mater Chem B 6:7811–7821. https://doi.org/10.1039/C8TB02244E
Yang R, Liu F, Wang J, Chen X, **e J, **ong K (2019) Epidermal stem cells in wound healing and their clinical applications. Stem Cell Res Ther 10:229. https://doi.org/10.1186/s13287-019-1312-z
Yang X, Wang Y, Zhou Y, Chen J, Wan Q (2021) The application of polycaprolactone in three-dimensional printing scaffolds for bone tissue engineering. Polymers 13:2754. https://doi.org/10.3390/polym13162754
You H-J, Han S-K (2014) Cell therapy for wound healing. J Korean Med Sci 29:311. https://doi.org/10.3346/jkms.2014.29.3.311
Yue S, He H, Li B, Hou T (2020) Hydrogel as a biomaterial for bone tissue engineering: a review. Nano 10:1511. https://doi.org/10.3390/nano10081511
Zeng Z (2010) Recent advances in PEG–PLA block copolymer nanoparticles. Int J Nanomedicine 5:1057–1065. https://doi.org/10.2147/IJN.S14912
Zhang Y, Wang C (2022) Recent advances in 3D printing hydrogel for topical drug delivery. MedComm Biomater Appl 1(1):mba2.11. https://doi.org/10.1002/mba2.11
Zhang D, Duan J, Wang D, Ge S (2010) Effect of preparation methods on mechanical properties of PVA/HA composite hydrogel. J Bionic Eng 7:235–243. https://doi.org/10.1016/S1672-6529(10)60246-6
Zhang B, Gao L, Ma L, Luo Y, Yang H, Cui Z (2019) 3D Bioprinting: a novel avenue for manufacturing tissues and organs. Engineering 5:777–794. https://doi.org/10.1016/j.eng.2019.03.009
Zhang M, Chang Z, Wang X, Li Q (2021) Synthesis of poly(l-lactide-co-ε-caprolactone) copolymer: structure, toughness, and elasticity. Polymers 13:1270. https://doi.org/10.3390/polym13081270
Zhao D, Wang X, Cheng B, Yin M, Hou Z, Li X, Liu K, Tie C, Yin M (2022) Degradation-kinetics-controllable and tissue-regeneration-matchable photocross-linked alginate hydrogels for bone repair. ACS Appl Mater Interfaces 14:21886–21905. https://doi.org/10.1021/acsami.2c01739
Zhu J (2010) Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials 31:4639–4656. https://doi.org/10.1016/j.biomaterials.2010.02.044
Zhu X, Zhong T, Huang R, Wan A (2015) Preparation of hydrophilic poly(lactic acid) tissue engineering scaffold via (PLA)-(PLA-b-PEG)-(PEG) solution casting and thermal-induced surface structural transformation. J Biomater Sci Polym Ed 26:1286–1296. https://doi.org/10.1080/09205063.2015.1088125
Zhu Y, Sazer D, Miller J, Warmflash A (2021) Rapid fabrication of hydrogel micropatterns by projection stereolithography for studying self-organized developmental patterning (preprint). Dev Biol. https://doi.org/10.1101/2021.01.04.425254
Zieger MAJ, Ochoa M, Rahimi R, Campana G, Tholpady S, Ziaie B, Sood R (2017) Skin regeneration using dermal substrates that contain autologous cells and silver nanoparticles to promote antibacterial activity. In Vitro Studies Mil Med 182:376–382. https://doi.org/10.7205/MILMED-D-16-00133
Zulkiflee I, Fauzi MB (2021) Gelatin-polyvinyl alcohol film for tissue engineering: a concise review. Biomedicine 9:979. https://doi.org/10.3390/biomedicines9080979
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Manjit, M., Mishra, B. (2024). Synthetic Polymer-Based Hydrogels for Tissue Engineering. In: Jana, S. (eds) Biomaterial-based Hydrogels. Springer, Singapore. https://doi.org/10.1007/978-981-99-8826-6_13
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