Abstract
Sleep disturbance is a commonly overlooked complication of hospitalized and intensive care unit (ICU) patients. Sleep in critically ill patients is often characterized by frequent disturbances to sleep structure, sleep depth, and changes in circadian rhythm that occur for a multitude of reasons. In an acute care setting, the quality of sleep is generally neglected due to the ongoing care of the patient’s illness. Medical personnel do not attach much importance to a patient’s sleep quality as they have many other duties and need to provide holistic care. Sleep disturbance due to increased awakenings in these clinical settings can have similar consequences and adverse health effects as sleep deprivation. It can negatively impact multiple organ systems, impeding overall well-being and prolonging the length of stay of these patients. There are various sleep measurement methods in ICU patients, although they do not all measure the same dimensions, and some of them are subjective and a few objective measurements. Many factors disturb the sleep of patients in an ICU setting, some of which consist of environmental factors, patient care activities including pharmacological and mechanical interventions, and patient-related factors. Changes in sleep structure develo** during an ICU stay may significantly contribute to sleep disorders that carry forward even after the hospitalization is over. Some of the measures aim at increasing patients’ comfort, reducing light and noise intensity at night, and an appropriate organization and aggregation of nursing care interventions to prevent sleep interruptions have been proven effective in sleep interruptions in an ICU setting. Awareness of the medical personnel and hospital employees along with interaction within the therapeutic team regarding the sleep-disturbing factors in the ICU setting and techniques for preventing it can significantly improve the quality of sleep of the patients. Here, in this chapter, we have highlighted the factors causing sleep disturbances, their physiological effects on different systems of the body and a few possible methods to mitigate these disturbances.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Beauchemin KM, Hays P (1998) Dying in the dark: sunshine, gender, and outcomes in myocardial infarction. J R Soc Med 91(7):352–354. https://doi.org/10.1177/014107689809100703
Bihari S, Doug McEvoy R, Matheson E, Kim S, Woodman RJ, Bersten AD (2012) Factors affecting sleep quality of patients in intensive care unit. J Clin Sleep Med 8(3):301–307. https://doi.org/10.5664/jcsm.1920
Bjurstrom MF, Irwin MR (2016) Polysomnographic characteristics in nonmalignant chronic pain populations: a review of controlled studies. Sleep Med Rev 26:74–86. https://doi.org/10.1016/j.smrv.2015.03.004
Bourne RS, Mills GH (2004) Sleep disruption in critically ill patients—pharmacological considerations. Anaesthesia 59(4):374–384. https://doi.org/10.1111/j.1365-2044.2004.03664.x
Bourne RS, Minelli C, Mills GH, Kandler R (2007) Clinical review: sleep measurement in critical care patients: research and clinical implications. Critical care (London, England) 11(4):226. https://doi.org/10.1186/cc5966
Cabello B, Thille AW, Drouot X, Galia F, Mancebo J, d’Ortho MP, Brochard L (2008) Sleep quality in mechanically ventilated patients: comparison of three ventilatory modes. Crit Care Med 36(6):1749–1755. https://doi.org/10.1097/CCM.0b013e3181743f41
Caldwell JR, Rapoport RJ, Davis JC, Offenberg HL, Marker HW, Roth SH, Yuan W, Eliot L, Babul N, Lynch PM (2002) Efficacy and safety of a once-daily morphine formulation in chronic, moderate-to-severe osteoarthritis pain: results from a randomized, placebo-controlled, double-blind trial and an open-label extension trial. J Pain Symptom Manag 23(4):278–291. https://doi.org/10.1016/s0885-3924(02)00383-4
Chang VA, Owens RL, LaBuzetta JN (2020) Impact of sleep deprivation in the neurological intensive care unit: a narrative review. Neurocrit Care 32(2):596–608. https://doi.org/10.1007/s12028-019-00795-4
Choi J, Beltrán LO, Kim H (2012) Impacts of indoor daylight environments on patient average length of stay (ALOS) in a healthcare facility. Build Environ 50:65–75
Delaney LJ, Van Haren F, Lopez V (2015) Slee** on a problem: the impact of sleep disturbance on intensive care patients—a clinical review. Ann Intensive Care 5:3. https://doi.org/10.1186/s13613-015-0043-2
Drouot X, Roche-Campo F, Thille AW, Cabello B, Galia F, Margarit L, d’Ortho MP, Brochard L (2012) A new classification for sleep analysis in critically ill patients. Sleep Med 13(1):7–14. https://doi.org/10.1016/j.sleep.2011.07.012
DuBose JR, Hadi K (2016) Improving inpatient environments to support patient sleep. Int J Qual Health Care 28(5):540–553. https://doi.org/10.1093/intqhc/mzw079
Dunn H, Anderson MA, Hill PD (2010) Nighttime lighting in intensive care units. Crit Care Nurse 30(3):31–37. https://doi.org/10.4037/ccn2010342
Freedman NS, Gazendam J, Levan L, Pack AI, Schwab RJ (2001) Abnormal sleep/wake cycles and the effect of environmental noise on sleep disruption in the intensive care unit. Am J Respir Crit Care Med 163(2):451–457. https://doi.org/10.1164/ajrccm.163.2.9912128
Granja C, Lopes A, Moreira S, Dias C, Costa-Pereira A, Carneiro A, JMIP Study Group (2005) Patients’ recollections of experiences in the intensive care unit may affect their quality of life. Critical care (London, England) 9(2):R96–R109. https://doi.org/10.1186/cc3026
Grossman MN, Anderson SL, Worku A, Marsack W, Desai N, Tuvilleja A, Ramos J, Francisco MA, Lafond C, Balachandran JS, Mokhlesi B, Farnan JM, Meltzer DO, Arora VM (2017) Awakenings? Patient and hospital staff perceptions of nighttime disruptions and their effect on patient sleep. J Clin Sleep Med 13(2):301–306. https://doi.org/10.5664/jcsm.6468
Honarmand K, Rafay H, Le J, Mohan S, Rochwerg B, Devlin JW, Skrobik Y, Weinhouse GL, Drouot X, Watson PL, McKinley S, Bosma KJ (2020) A systematic review of risk factors for sleep disruption in critically ill adults. Crit Care Med 48(7):1066–1074. https://doi.org/10.1097/CCM.0000000000004405
Huang HW, Zheng BL, Jiang L, Lin ZT, Zhang GB, Shen L, ** XM (2015) Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep-in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation? Crit Care (London, England) 19(1):124. https://doi.org/10.1186/s13054-015-0842-8
Kamdar BB, Needham DM, Collop NA (2012a) Sleep deprivation in critical illness: its role in physical and psychological recovery. J Intensive Care Med 27(2):97–111. https://doi.org/10.1177/0885066610394322
Kamdar BB, Shah PA, King LM, Kho ME, Zhou X, Colantuoni E, Collop NA, Needham DM (2012b) Patient-nurse interrater reliability and agreement of the Richards-Campbell sleep questionnaire. Am J Crit Care 21(4):261–269. https://doi.org/10.4037/ajcc2012111
Le A, Friese RS, Hsu CH, Wynne JL, Rhee P, O’Keeffe T (2012) Sleep disruptions and nocturnal nursing interactions in the intensive care unit. J Surg Res 177(2):310–314. https://doi.org/10.1016/j.jss.2012.05.038
Lee CY, Low LP, Twinn S (2007) Older men’s experiences of sleep in the hospital. J Clin Nurs 16(2):336–343. https://doi.org/10.1111/j.1365-2702.2005.01491.x
Lewandowska K, Mędrzycka-Dąbrowska W, Pilch D, Wach K, Fortunato A, Krupa S, Ozga D (2020) Sleep deprivation from the perspective of a patient hospitalized in the intensive care unit-qualitative study. Healthcare (Basel, Switzerland) 8(3):351. https://doi.org/10.3390/healthcare8030351
Medrzycka-Dabrowska W, Lewandowska K, Kwiecień-Jaguś K, Czyż-Szypenbajl K (2018) Sleep deprivation in Intensive Care Unit—systematic review. Open Med 13(1):384–393. https://doi.org/10.1515/med-2018-0057
Meyer TJ, Eveloff SE, Bauer MS, Schwartz WA, Hill NS, Millman RP (1994) Adverse environmental conditions in the respiratory and medical ICU settings. Chest 105(4):1211–1216. https://doi.org/10.1378/chest.105.4.1211
Mukherjee S, Patel SR, Kales SN, Ayas NT, Strohl KP, Gozal D, Malhotra A, American Thoracic Society Ad hoc Committee on Healthy Sleep (2015) An official American Thoracic Society statement: the importance of healthy sleep. Recommendations and future priorities. Am J Respir Crit Care Med 191(12):1450–1458. https://doi.org/10.1164/rccm.201504-0767ST
Murphy PJ, Badia P, Myers BL, Boecker MR, Wright KP Jr (1994) Nonsteroidal anti-inflammatory drugs affect normal sleep patterns in humans. Physiol Behav 55(6):1063–1066. https://doi.org/10.1016/0031-9384(94)90388-3
Nilius G, Richter M, Schroeder M (2021) Updated perspectives on the management of sleep disorders in the intensive care unit. Nat Sci Sleep 13:751–762. https://doi.org/10.2147/NSS.S284846
Parthasarathy S, Tobin MJ (2002) Effect of ventilator mode on sleep quality in critically ill patients. Am J Respir Crit Care Med 166(11):1423–1429. https://doi.org/10.1164/rccm.200209-999OC
Pulak LM, Jensen L (2016) Sleep in the intensive care unit: a review. J Intensive Care Med 31(1):14–23. https://doi.org/10.1177/0885066614538749
Shilo L, Dagan Y, Smorjik Y, Weinberg U, Dolev S, Komptel B, Shenkman L (2000) Effect of melatonin on sleep quality of COPD intensive care patients: a pilot study. Chronobiol Int 17(1):71–76. https://doi.org/10.1081/cbi-10010103
Spengler CM, Shea SA (2000) Sleep deprivation per se does not decrease the hypercapnic ventilatory response in humans. Am J Respir Crit Care Med 161(4 Pt 1):1124–1128. https://doi.org/10.1164/ajrccm.161.4.9906026
Spiegel K, Leproult R, Van Cauter E (1999) Impact of sleep debt on metabolic and endocrine function. Lancet (London, England) 354(9188):1435–1439. https://doi.org/10.1016/S0140-6736(99)01376-8
Tan X, van Egmond L, Partinen M, Lange T, Benedict C (2019) A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients. Sleep Med 59:42–50. https://doi.org/10.1016/j.sleep.2018.08.007
Toublanc B, Rose D, Glérant JC, Francois G, Mayeux I, Rodenstein D, Jounieaux V (2007) Assist-control ventilation vs. low levels of pressure support ventilation on sleep quality in intubated ICU patients. Intensive Care Med 33(7):1148–1154. https://doi.org/10.1007/s00134-007-0659-2
Weenk M, van Goor H, Frietman B, Engelen LJ, van Laarhoven CJ, Smit J, Bredie SJ, van de Belt TH (2017) Continuous monitoring of vital signs using wearable devices on the general Ward: pilot study. JMIR Mhealth Uhealth 5(7):e91. https://doi.org/10.2196/mhealth.7208
Wolkowitz OM, Rubinow D, Doran AR, Breier A, Berrettini WH, Kling MA, Pickar D (1990) Prednisone effects on neurochemistry and behavior. Preliminary findings. Arch Gen Psychiatry 47(10):963–968. https://doi.org/10.1001/archpsyc.1990.01810220079010
Yadav SK, Kumar R, Macey PM, Richardson HL, Wang DJ, Woo MA, Harper RM (2013) Regional cerebral blood flow alterations in obstructive sleep apnea. Neurosci Lett 555:159–164. https://doi.org/10.1016/j.neulet.2013.09.033
Yoder JC, Staisiunas PG, Meltzer DO, Knutson KL, Arora VM (2012) Noise and sleep among adult medical inpatients: far from a quiet night. Arch Intern Med 172(1):68–70. https://doi.org/10.1001/archinternmed.2011.603
Zhong X, Hilton HJ, Gates GJ, Jelic S, Stern Y, Bartels MN, Demeersman RE, Basner RC (2005) Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. J Appl Physiol (Bethesda, Md.: 1985) 98(6):2024–2032. https://doi.org/10.1152/japplphysiol.00620.2004
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Vaishnav, P.P., Suresh, A., Kooragayalu, S., Kooragayalu, S. (2023). Sleep Disturbances in Hospitalized and Intensive Care Unit Patients. In: BaHammam, A.S., Hunasikatti, M. (eds) Sleep Apnea Frontiers. Progress in Sleep Research. Springer, Singapore. https://doi.org/10.1007/978-981-99-7901-1_15
Download citation
DOI: https://doi.org/10.1007/978-981-99-7901-1_15
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-7900-4
Online ISBN: 978-981-99-7901-1
eBook Packages: MedicineMedicine (R0)