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Cell Blocks in Cytopathology and Their Role in Evaluation of Thyroid Aspirates

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Thyroid FNA Cytology

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Abstract

With the impetus shifting to minimally invasive procedures, cytology sampling has become of paramount significance, and CBs provide a multifaceted platform for auxiliary testing. Currently, various methods of CB preparation are available, each with their own merits and demerits owing to various factors related both to the acquisition of samples and the processing of specimens. FNA has been a powerful diagnostic tool for evaluation of thyroid nodules, effectively reducing unnecessary surgeries. Recent advances in the understanding of the molecular pathways underlying thyroid carcinogenesis have led to the evolution of a new diagnostic approach with incorporation of immunohistochemical and molecular testing leading to the generation of an integrative diagnostic report. In this context, the role of CBs in thyroid cytology can hardly be overstated. The combination of cytology with cell block in thyroid aspirates have not only increased the representativeness of the samples with lower false-negative rates but also added to the possibility of commissioning immunocytochemistry and molecular analyses, whenever needed. However, this results in an increased turnover time with added burden in manpower and cost restrained settings. In such circumstances, an apt resolution would be to prepare CBs only as needed, for instance, in case of ambiguous results of the aspirate smears or the need to employ ancillary tests for confirmation of the diagnosis.

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Authors and Affiliations

  1. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Rimlee Dutta & Deepali Jain

  2. Department of Cytology and Gynecologic pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Manish Rohilla & Radhika Srinivasan

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  1. Rimlee Dutta
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  2. Manish Rohilla
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  3. Radhika Srinivasan
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  4. Deepali Jain
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Correspondence to Deepali Jain .

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Editors and Affiliations

  1. Department of Pathology, Cancer Genome Center & Thyroid Disease Center, Izumi City General Hospital, Izumi, Osaka, Japan

    Kennichi Kakudo

  2. Department of Pathology, Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Zhiyan Liu

  3. Department of Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (Republic of)

    Chan Kwon Jung

  4. Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan

    Mitsuyoshi Hirokawa

  5. Department of Pathology, Kameda Medical Center, Kamogawa, Japan

    Andrey Bychkov

  6. Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Chiung-Ru Lai

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Dutta, R., Rohilla, M., Srinivasan, R., Jain, D. (2023). Cell Blocks in Cytopathology and Their Role in Evaluation of Thyroid Aspirates. In: Kakudo, K., Liu, Z., Jung, C.K., Hirokawa, M., Bychkov, A., Lai, CR. (eds) Thyroid FNA Cytology. Springer, Singapore. https://doi.org/10.1007/978-981-99-6782-7_75

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