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Functional Biomaterials for Targeted Drug Delivery Applications

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Functional Smart Nanomaterials and Their Theranostics Approaches

Part of the book series: Smart Nanomaterials Technology ((SNT))

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Abstract

Targeted drug delivery approaches have been widely employed to regulate the absorption and biodistribution of small molecules and biologics at the targeted diseased sites to maximize therapeutic performances without affecting the healthy cells of the tissue or organ inside the body. For this purpose, it is essential to select effective biomaterial-based platforms that can release drugs in a sustained manner without altering their bioactivity and causing toxic effects in off-targeted tissues. Such biomaterials can be directly implanted/injected into the targeted diseased area of the body to enhance drug delivery efficiency. Various materials have been explored to fabricate targeted drug delivery systems. Functional biomaterials with desired physicochemical and biological properties are getting colossal attention because they can respond to their environmental cues, such as fluctuations in pH, temperature, or cell-associated enzymatic activity, and improve drug delivery integration and tissue regeneration. This chapter explores the progress of different approaches in functionalizing polymeric, metallic, and ceramic biomaterials for targeted drug delivery systems.

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Authors and Affiliations

  1. Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat, India

    Hemant Singh, Muzammil Kuddushi, Ramesh Singh, Sneha Sathapathi, Aniruddha Dan, Dhiraj Bhatia & Mukesh Dhanka

  2. Department of Chemical and Materials Engineering, University of Alberta, Alberta, Canada

    Muzammil Kuddushi

  3. Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India

    Narayan Chandra Mishra

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  1. Department of Chemistry, The University of Memphis, Memphis, TN, USA

    Alle Madhusudhan

  2. School of Chemical Engineering, Yeungnam University, Gyeongsan, Korea (Republic of)

    Shiv Dutt Purohit

  3. School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, India

    Rajendra Prasad

  4. Department of Biotechnology, Smt. S. S. Patel Nootan Science & Commerce College, Sankalchand Patel University, Visnagar, Gujarat, India

    Azamal Husen

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Singh, H. et al. (2024). Functional Biomaterials for Targeted Drug Delivery Applications. In: Madhusudhan, A., Purohit, S.D., Prasad, R., Husen, A. (eds) Functional Smart Nanomaterials and Their Theranostics Approaches. Smart Nanomaterials Technology. Springer, Singapore. https://doi.org/10.1007/978-981-99-6597-7_2

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