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Abstract

Microscopic polyangiitis (MPA) is a kind of systemic vasculitis, which mainly involves small vessels, including arterioles, capillary arteries, capillaries, capillary venules, and medium-sized arteries. MPA most often invades the kidneys, lungs, and skin. MPA is the most common cause of pulmonary hemorrhage-nephritis syndrome.

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References

  1. Jennette JC. Overview of the 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. Clin Exp Nephrol. 2013;17(5):603–6.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Hogan SL, Falk RJ, Chin H, et al. Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. Ann Intern Med. 2005;143(9):621–31.

    Article  PubMed  Google Scholar 

  3. Furuta S, Chaudhry AN, Hamano Y, et al. Comparison of phenotype and outcome in microscopic polyangiitis between Europe and Japan. J Rheumatol. 2014;41(2):325–33.

    Article  PubMed  Google Scholar 

  4. Qu H, Yu R, Cui F, et al. Chest CT features of microscopic polyangitis. Chin J Radiol. 2011;45(5):441–4.

    Google Scholar 

  5. Suzuki A, Sakamoto S, Kurosaki A, et al. Chest high-resolution CT findings of microscopic polyangiitis: a Japanese first nationwide prospective cohort study. Am J Roentgenol. 2019;213(1):104–14.

    Article  Google Scholar 

  6. Yamagata M, Ikeda K, Tsushima K, et al. Prevalence and responsiveness to treatment of lung abnormalities on chest computed tomography in patients with microscopic polyangiitis: a multicenter, longitudinal, retrospective study of one hundred fifty consecutive hospital-based Japanese patients. Arthritis Rheumatol. 2016;68(3):713–23.

    Article  CAS  PubMed  Google Scholar 

  7. Hosoda C, Baba T, Hagiwara E, et al. Clinical features of usual interstitial pneumonia with anti-neutrophil cytoplasmic antibody in comparison with idiopathic pulmonary fibrosis. Respirology. 2016;21(5):920–6.

    Article  PubMed  Google Scholar 

  8. Kida T, Tanaka T, Yokota I, et al. Association between preexisting lung involvements and the risk of diffuse alveolar hemorrhage in patients with microscopic polyangiitis: a multi-center retrospective cohort study. Mod Rheumatol. 2020;30(2):338–44.

    Article  PubMed  Google Scholar 

  9. Néel A, Espitia-Thibault A, Arrigoni PP, et al. Bronchiectasis is highly prevalent in anti-MPO ANCA-associated vasculitis and is associated with a distinct disease presentation. Semin Arthritis Rheum. 2018;48(1):70–6.

    Article  PubMed  Google Scholar 

  10. Takahashi H, Tsuboi H, Abe S, et al. Magnetic resonance imaging can reveal fascial vasculitis in a patient with microscopic polyangiitis. Scand J Rheumatol. 2015;44(6):511–3.

    Article  CAS  PubMed  Google Scholar 

  11. Falk RJ, Gross WL, Guillevin L, et al. Granulomatosis with polyangiitis (Wegener’s): an alternative name for Wegener’s granulomatosis. J Am Soc Nephrd. 2011;22(4):587–8.

    Article  Google Scholar 

  12. Greco A, Marinelli C, Fusconi M, et al. Clinic manifestations in granulomatosis with polyangiitis. Int J Immunopathol Pharmacol. 2016;29(2):151–9.

    Article  CAS  PubMed  Google Scholar 

  13. Groheux D, Quere G, Blanc E, et al. FDG PET-CT for solitary pulmonary nodule and lung cancer: literature review. Diagn Interv Imaging. 2016;97(10):1003–17.

    Article  CAS  PubMed  Google Scholar 

  14. **ang YW, Sun YF, Liu Y, et al. Development and validation of a predictive model for the diagnosis of solid solitary pulmonary nodules using data mining methods. J Thorac Dis. 2019;11(3):950–8.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides: the proposal of an international consensus conference. Arthritis Rheum. 1994;37(2):187–92.

    Article  CAS  PubMed  Google Scholar 

  16. Zhang Q. Multidisciplinary expert consensus on diagnosis and treatment of eosinophilic granulomatosis with polyangiitis. Chin J Tubercul Resp Dis. 2018;41(7):514–21.

    Google Scholar 

  17. Pagnoux C, Guillevin L. Churg-Strauss syndrome: evidence for disease subtypes? Curr Opin Rheumatol. 2010;22(1):21–8.

    Article  PubMed  Google Scholar 

  18. Szczeklik W, Sokołowska B, Mastalerz L, et al. Pulmonary findings in Churg-Strauss syndrome in chest X-rays and high-resolution computed tomography at the time of initial diagnosis. Clin Rheumatol. 2010;29(10):1127–34.

    Article  PubMed  Google Scholar 

  19. Kim YK, Lee KS, Chung MP, et al. Pulmonary involvement in Churg-Strauss syndrome: an analysis of CT, clinical, and pathologic findings. Eur Radiol. 2007;17(12):3157–65.

    Article  PubMed  Google Scholar 

  20. Mahr A, Moosig F, Neumann T, et al. Osinophilic granulomatosis with polyangiitis (Churg-Strauss): evolutions in classification, etiopathogenesis, assessment and management. Curr Opin Rheumatol. 2014;26(1):16–23.

    Article  CAS  PubMed  Google Scholar 

  21. Bloch DA, Michel BA, Hunder GG, et al. The American College of Rheumatology 1990 criteria for the classification of vasculitis. Patients and methods Arthritis Rheum. 1990;33(8):1068–73.

    Article  CAS  PubMed  Google Scholar 

  22. Lanham JG, Elkon KB, Pusey CD, et al. Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome. Medicine (Baltimore). 1984;63(2):65–81.

    Article  CAS  PubMed  Google Scholar 

  23. Jeong YJ, Kim KI, Seo IJ, et al. Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. Radiographics. 2007;27(3):617–37.

    Article  PubMed  Google Scholar 

  24. Neumann T, Manger B, Schmid M, et al. Cardiac involvement in Churg-Strauss syndrome: impact of endomyocarditis. Medicine (Baltimore). 2009;88(4):236–43.

    Article  PubMed  Google Scholar 

  25. d’Ersu E, Ribi C, Monney P, et al. Churg-Strauss syndrome with cardiac involvement: case illustration and contribution of CMR in the diagnosis and clinical follow-up. Int J Cardiol. 2018;258:321–4.

    Article  PubMed  Google Scholar 

  26. Zheng W, Li L. Interpretation of the latest EULAR guidelines for clinical management of Behcet’s syndrome in 2018. Chin J Allergy Clin Immunol. 2018;12(3):259–62.

    Google Scholar 

  27. Koç Y, Güllü I, Akpek G, et al. Vascular involvement in Behcet’s disease. J Rheumatol. 1992;19(3):402–10.

    PubMed  Google Scholar 

  28. Fei YY, Li XM, Lin S, et al. Major vascular involvement in Behcet’s disease: a retrospective study of 796 patients. Clin Rheumatol. 2013;32(6):845–52.

    Article  PubMed  Google Scholar 

  29. Seyahi E, Melikoglu M, Akman C, et al. Pulmonary artery involvement and associated lung disease in Behcet disease: a series of 47 patients. Medicine (Baltimore). 2012;91(1):35–48.

    Article  PubMed  Google Scholar 

  30. Zhang X, Dai H, Ma Z, et al. Pulmonary involvement in patients with Behcet’s disease: report of 15 cases. Clin Respir J. 2015;9(4):414–22.

    Article  PubMed  Google Scholar 

  31. Trad S, Bensimhon L, El Hajjam M, et al. 18F-fluorodeoxyglucose-positron emission tomography scanning is a useful tool for therapy evaluation of arterial aneurysm in Behcet’s disease. Joint Bone Spine. 2013;80(4):420–3.

    Article  PubMed  Google Scholar 

  32. Uygunoglu U, Zeydan B, Ozguler Y, et al. Myelopathy in Behcet’s disease: the bagel sign. Ann Neurol. 2017;82(2):288–98.

    Article  PubMed  Google Scholar 

  33. Aykac SC, Gökcay F, Calli C. What is the role of diffusion tensor imaging (DTI) in detecting subclinical pyramidal tract dysfunction in Behcet’s and neuro-Behcet’s cases. Neurol Sci. 2019;40(4):753–8.

    Article  PubMed  Google Scholar 

  34. Chinese Rheumatology Association. Guidelines for diagnosis and treatment of polyarteritis nodosa. Chin J Rheumatol. 2011;15(3):192–3.

    Google Scholar 

  35. Guo X, Gopalan R, Ugbarugba S, et al. Hepatitis B-related polyarteritis nodosa complicated by pulmonary hemorrhage. Chest. 2001;119(5):1608–10.

    Article  CAS  PubMed  Google Scholar 

  36. Menon Y, Singh R, Cuchacovich R, et al. Pulmonary involvement in hepatitis B-related polyarteritis nodosa. Chest. 2002;122(4):1497–8.

    Article  PubMed  Google Scholar 

  37. Matsumoto T, Homma S, Okada M, et al. The lung in polyarteritis nodosa: a pathologic study of 10 cases. Hum Pathol. 1993;24(7):717–24.

    Article  CAS  PubMed  Google Scholar 

  38. Lee YJ, Park SS, Kim SY, et al. A case of systemic polyarteritis nodosa involving bronchial artery. Sarcoidosis Vasc Diffuse Lung Dis. 2010;27(2):164–8.

    CAS  PubMed  Google Scholar 

  39. Nick J, Tuder R, May R, et al. Polyarteritis nodosa with pulmonary vasculitis. Am J Respir Crit Care Med. 1996;153(1):450–3.

    Article  CAS  PubMed  Google Scholar 

  40. Takei H, Hanaoka H, Kaneko Y, et al. Intriguing findings of the muscle on magnetic resonance imaging in polyarteritis nodosa. Intern Med. 2016;55(21):3197–200.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Schollhammer R, Schwartz P, Jullie ML, et al. 18F-FDG PET/CT imaging of popliteal vasculitis associated with polyarteritis nodosa. Clin Nucl Med. 2017;42(8):e385–7.

    Article  PubMed  Google Scholar 

  42. Chinese Rheumatology Association. Guidelines for diagnosis and treatment of Takayasu arteritis. Chin J Rheumatol. 2011;15(2):119–20.

    Google Scholar 

  43. Ozen S, Ruperto N, Dillon MJ, et al. EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides. Ann Rheum Dis. 2006;65(7):936–41.

    Article  CAS  PubMed  Google Scholar 

  44. Zhu FP, Luo S, Wang ZJ, et al. Takayasu arteritis: imaging spectrum at multidetector CT angiography. Br J Radiol. 2012;85(1020):e1282–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Sun Y, Huang Q, Jiang L. Radiology and biomarkers in assessing disease activity in Takayasu arteritis. Int J Rheum Dis. 2019;22(Suppl 1):53–9.

    Article  PubMed  Google Scholar 

  46. Meller J, Strutz F, Siefker U, et al. Early diagnosis and follow-up of aortitis with [(18)F]FDG PET and MRI. Eur J Nucl Med Mol Imaging. 2003;30(5):730–6.

    Article  CAS  PubMed  Google Scholar 

  47. Lamare F, Hinz R, Gaemperli O, et al. Detection and quantification of large-vessel inflammation with 11C-(R)-PK11195 PET/CT. J Nucl Med. 2011;52(1):33–9.

    Article  PubMed  Google Scholar 

  48. Einspieler I, Thürmel K, Pyka T, et al. Imaging large vessel vasculitis with fully integrated PET/MRI: a pilot study. Eur J Nucl Med Mol Imaging. 2015;42(7):1012–24.

    Article  CAS  PubMed  Google Scholar 

  49. Giordana P, Baqué-juston MC, Jeandel PY, et al. Contrast-enhanced ultrasound of carotid artery wall in Takayasu disease: first evidence of application in diagnosis and monitoring of response to treatment. Circulation. 2011;124(2):245–7.

    Article  CAS  PubMed  Google Scholar 

  50. Greco A, Rizzo MI, de Virgilio A, et al. Goodpasture’s syndrome: a clinical update. Autoimmun Rev. 2015;14(3):246–53.

    Article  PubMed  Google Scholar 

  51. McAdoo SP, Pusey CD. Anti-glomerular basement membrane disease. Clin J Am Soc Nephrol. 2017;12(7):1162–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Tashiro H, Takahashi K, Ikeda Y, et al. Pre-existing chronic interstitial pneumonia is a poor prognostic factor of Goodpasture’s syndrome: a case report and review of the literature. J Med Case Rep. 2017;11(1):102.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Lichtenberger JP, Digumarthy SR, Abbott GF, et al. Diffuse pulmonary hemorrhage: clues to the diagnosis. Curr Probl Diagn Radiol. 2014;43(3):128–39.

    Article  PubMed  Google Scholar 

  54. Primack SL, Miller RR, Müller NL. Diffuse pulmonary hemorrhage: clinical, pathologic, and imaging features. Am J Roentgenol. 1995;164(2):295–300.

    Article  CAS  Google Scholar 

  55. Kloth C, Thaiss WM, Beck R, et al. Potential role of CT-textural features for differentiation between viral interstitial pneumonias, pneumocystis jirovecii pneumonia and diffuse alveolar hemorrhage in early stages of disease: a proof of principle. BMC Med Imaging. 2019;19(1):39.

    Article  PubMed  PubMed Central  Google Scholar 

  56. de Silva C, Mukherjee A, Jat KR, et al. Pulmonary hemorrhage in children: etiology, clinical profile and outcome. Indian J Pediatr. 2019;86(1):7–11.

    Article  PubMed  Google Scholar 

  57. Khorashadi L, Wu CC, Betancourt SL, et al. Idiopathic pulmonary haemosiderosis: spectrum of thoracic imaging findings in the adult patient. Clin Radiol. 2015;70(5):459–65.

    Article  CAS  PubMed  Google Scholar 

  58. Watanabe H, Ayusawa M, Kato M, et al. Idiopathic pulmonary hemosiderosis complicated by down syndrome. Pediatr Int. 2015;57(5):1009–12.

    Article  PubMed  Google Scholar 

  59. Chen XY, Sun JM, Huang XJ. Idiopathic pulmonary hemosiderosis in adults: review of cases reported in the latest 15 years. Clin Respir J. 2017;11(6):677–81.

    Article  PubMed  Google Scholar 

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Wang, K., Xu, Y. (2023). Vasculitis. In: Li, H., Liu, J., Li, L. (eds) Radiology of Infectious and Inflammatory Diseases - Volume 3. Springer, Singapore. https://doi.org/10.1007/978-981-99-4614-3_20

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  • DOI: https://doi.org/10.1007/978-981-99-4614-3_20

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